ChemicalBook > CAS DataBase List > 4-Iodophenol

4-Iodophenol

Product Name
4-Iodophenol
CAS No.
540-38-5
Chemical Name
4-Iodophenol
Synonyms
P-IODOPHENOL;p-Jodphenol;p-iodo-pheno;4-iodo-pheno;4-IODOPHENOL;4-lodophenoI;PHENOL, 4-IODO-;Phenol, p-iodo-;I**4-Iodophenol;4-Iodophenol99%
CBNumber
CB8328252
Molecular Formula
C6H5IO
Formula Weight
220.01
MOL File
540-38-5.mol
More
Less

4-Iodophenol Property

Melting point:
92-94 °C(lit.)
Boiling point:
138 °C5 mm Hg(lit.)
Density 
1.8573
Flash point:
138°C/5mm
storage temp. 
Refrigerator
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Crystals or Crystalline Powder
pka
9.33(at 25℃)
color 
Pink or beige to brown
Water Solubility 
slightly soluble
Sensitive 
Light Sensitive
Merck 
14,5036
BRN 
1904544
Stability:
Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference
540-38-5(CAS DataBase Reference)
NIST Chemistry Reference
Phenol, 4-iodo-(540-38-5)
EPA Substance Registry System
p-Iodophenol (540-38-5)
More
Less

Safety

Hazard Codes 
C,Xi,Xn
Risk Statements 
21/22-34-36/37/38-20/21/22
Safety Statements 
26-36/37/39-45-22
RIDADR 
UN 3261 8/PG 3
WGK Germany 
3
RTECS 
SL5600000
Hazard Note 
Irritant
TSCA 
T
HazardClass 
IRRITANT, LACHRYMATOR
HS Code 
29081900
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
I10201
Product name
4-Iodophenol
Purity
99%
Packaging
10g
Price
$65.6
Updated
2024/03/01
Sigma-Aldrich
Product number
I10201
Product name
4-Iodophenol
Purity
99%
Packaging
25g
Price
$103
Updated
2024/03/01
TCI Chemical
Product number
I0311
Product name
4-Iodophenol
Purity
>98.0%(GC)
Packaging
10g
Price
$46
Updated
2024/03/01
TCI Chemical
Product number
I0311
Product name
4-Iodophenol
Purity
>98.0%(GC)
Packaging
25g
Price
$88
Updated
2024/03/01
Alfa Aesar
Product number
A13455
Product name
4-Iodophenol, 98+%
Packaging
5g
Price
$21.65
Updated
2024/03/01
More
Less

4-Iodophenol Chemical Properties,Usage,Production

Chemical Properties

Light brown powder. It dissolves slightly in water, but readily dissolves in ethanol, ether, and other organic solvents.

Uses

4-Iodophenol is used in chemiluminescence imaging assays and experiments, as diagnostic agents in order to detect cancer cells in patients. It is also utilized in synthesizing agonists for the estrogen β receptor. Additionally, The compound finds extensive applications in various medical industries as well as in human and animal nutrition products such as pharmaceutical intermediates, and polarizing films for Liquid Crystal Display (LCD) chemicals.

Preparation

It is obtained from 4-Aminophenol by diazotisation and substitution.

Application

4-Iodophenol can be used as a building block for the synthesis of:
Hydroxybiaryls by reacting with aryl boronic acids via Pd-catalyzed Suzuki-Miyaura coupling reaction.[1][2]
Aryl substituted olefins by reacting with acrylates via Pd-catalyzed Heck reaction.[3]
Iodinated-4-aryloxymethylcoumarins [4]
Hydroxylated stilbenoids [5] and psammaplysenes A and B.[6]

Definition

ChEBI: 4-iodophenol is an iodophenol.

Synthesis Reference(s)

Organic Syntheses, Coll. Vol. 2, p. 355, 1943
The Journal of Organic Chemistry, 70, p. 8590, 2005 DOI: 10.1021/jo051191x
Tetrahedron Letters, 40, p. 6051, 1999 DOI: 10.1016/S0040-4039(99)01236-8

Metabolism

4-Iodophenol has known human metabolites that include (2S,3S,4S,5R)-3,4,5-trihydroxy-6-(4-iodophenoxy)oxane-2-carboxylic acid.

Purification Methods

Crystallise 4-iodophenol from pet ether (b 80-100o) or distil it in vacuo. If the material has a brown or violet color, then dissolve it in CHCl3, shake it with 5% sodium thiosulfate solution until is colourless. Dry (Na2SO4), extract, evaporate and disil the residue in vacuo. [Dains & Eberly Org Synth Coll Vol II 355 1948, Beilstein 6 IV 1074.]

References

[1] HIDEHIRO SAKURAI Toshikazu H Tatsuya Tsukuda. Pd/C as a Reusable Catalyst for the Coupling Reaction of Halophenols and Arylboronic Acids in Aqueous Media[J]. The Journal of Organic Chemistry, 2002, 67 8: 2721-2722. DOI:10.1021/jo016342k.
[2] PIOTR WAWRZYNIAK Joachim H. Microwave-Promoted Suzuki—Miyaura Coupling of Arylboronic Acids with 1-Bromo-2-naphthol, o-Bromophenol, and o-Chlorophenol.[J]. ChemInform, 2007, 38 14. DOI:10.1002/chin.200714105.
[3] LUNXIANG YIN Juergen L. Carbon—Carbon Coupling Reactions Catalyzed by Heterogeneous Palladium Catalysts[J]. ChemInform, 2007, 38 22. DOI:10.1002/chin.200722237.
[4] MAHANTESHA BASANAGOUDA . Synthesis, structure–activity relationship of iodinated-4-aryloxymethyl-coumarins as potential anti-cancer and anti-mycobacterial agents[J]. European Journal of Medicinal Chemistry, 2014, 74: Pages 225-233. DOI:10.1016/j.ejmech.2013.12.061.
[5] AMIT SHARD. Tandem Heck/Decarboxylation/Heck Strategy: Protecting-Group-Free Synthesis of Symmetric and Unsymmetric Hydroxylated Stilbenoids?[J]. Angewandte Chemie International Edition, 2012, 51 49: 12250-12253. DOI:10.1002/anie.201206346.
[6] SAVVAS N. GEORGIADES Jon C. Total Synthesis of Psammaplysenes A and B, Naturally Occurring Inhibitors of FOXO1a Nuclear Export[J]. Organic Letters, 2005, 7 19: 4091-4094. DOI:10.1021/ol0513286.

4-Iodophenol Preparation Products And Raw materials

Raw materials

Copper 4-Aminophenol

Preparation Products

4-Iodophenoxyacetic acid
More
Less

4-Iodophenol Suppliers

Americas 1 Austria 1 Belgium 1 Canada 1 China 241 Europe 3 Germany 8 India 61 Japan 8 Slovakia 1 South Korea 1 Switzerland 2 The Netherlands 1 Ukraine 2 United Kingdom 20 United States 52 Global 404
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10186
Advantage
62
HBCChem, Inc.
Tel
+1-510-219-6317
Fax
+1-650-486-1361
Email
sales@hbcchem.com
Country
United States
ProdList
10648
Advantage
60
Alchem Pharmtech,Inc.
Tel
8485655694
Email
sales@alchempharmtech.com
Country
United States
ProdList
63687
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
Chemphtec Corporation
Tel
--
Fax
--
Email
fo@chemphtec.com
Country
United States
ProdList
2181
Advantage
58
Tosoh USA, Inc. (part of Tosoh Corporation)
Tel
--
Fax
--
Email
info.tusa@tosoh.com
Country
United States
ProdList
32
Advantage
58
Fine Chem Trading LTD
Tel
--
Fax
--
Email
chemfinder@chemfinder.co.uk
Country
United States
ProdList
1609
Advantage
64
Oakwood Products, Inc.
Tel
--
Fax
--
Email
sales@oakwoodchemical.com
Country
United States
ProdList
6193
Advantage
74
SynQuest Laboratories, Inc.
Tel
--
Fax
--
Email
info@synquestlabs.com
Country
United States
ProdList
6871
Advantage
62
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
TCI America
Tel
--
Fax
--
Email
sales@tciamerica.com
Country
United States
ProdList
6909
Advantage
75
Frontier Scientific, Inc.
Tel
--
Fax
--
Email
sales@frontiersci.com
Country
United States
ProdList
6222
Advantage
86
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
Lianyungang Ziyan Chemical Co., Ltd.
Tel
--
Fax
--
Email
ziyanchem@gmail.com
Country
United States
ProdList
360
Advantage
0
Boron Molecular Inc.
Tel
--
Fax
--
Email
sales@boronmolecular-usa.com
Country
United States
ProdList
996
Advantage
65
Accela ChemBio Inc.
Tel
--
Fax
--
Email
info@accelachem.com
Country
United States
ProdList
1054
Advantage
50
OMKAR CHEMICALS & RESEARCH LABS..
Tel
--
Fax
--
Email
rishi@bom8.vsnl.net.in
Country
United States
ProdList
87
Advantage
51
HBCChem Inc.
Tel
--
Fax
--
Email
sales@hbcchem-inc.com
Country
United States
ProdList
4569
Advantage
30
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6962
Advantage
56
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
Advantage
30
AlliChem, LLC
Tel
--
Fax
--
Email
sales@allichemllc.com
Country
United States
ProdList
6516
Advantage
60
Magical Scientific LLC
Tel
--
Fax
--
Country
United States
ProdList
703
Advantage
0
ChemService Inc.
Tel
--
Fax
--
Country
United States
ProdList
6379
Advantage
68
Combi-Blocks Inc.
Tel
--
Fax
--
Email
sales@combi-blocks.com
Country
United States
ProdList
6618
Advantage
69
AstaTech, Inc
Tel
--
Fax
--
Email
sales@astatechinc.com
Country
United States
ProdList
6371
Advantage
58
Narchem Corporation
Tel
--
Fax
--
Email
sales@narchem.com
Country
United States
ProdList
2813
Advantage
60
Ivy Fine Chemicals
Tel
--
Fax
--
Email
sales@ivychem.com
Country
United States
ProdList
6493
Advantage
58
Leonid Chemicals Private Limited
Tel
--
Fax
--
Email
careers@leonidchemicals.com
Country
United States
ProdList
1700
Advantage
43
Alfa Aesar
Tel
--
Fax
--
Email
tech@alfa.com
Country
United States
ProdList
6814
Advantage
81
Beta Pharma, Inc.
Tel
--
Fax
--
Email
sales@betapharma.com
Country
United States
ProdList
6226
Advantage
60
HONEST JOY HOLDINGS LIMITED
Tel
--
Fax
--
Email
sales@honestjoy.cn
Country
United States
ProdList
6675
Advantage
54
2A PharmaChem USA
Tel
--
Fax
--
Email
sales@2apharmachem.com
Country
United States
ProdList
6137
Advantage
39
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6718
Advantage
47
Aagile Labs Division of Tyger Scientific
Tel
--
Fax
--
Email
tygersci@yahoo.com
Country
United States
ProdList
6568
Advantage
68
TimTec Corporation
Tel
--
Fax
--
Country
United States
ProdList
1945
Advantage
58
Syntech Labs
Tel
--
Fax
--
Email
info@syntechlabs.com
Country
United States
ProdList
730
Advantage
43
Wintersun Chemical
Tel
--
Fax
--
Email
purchasing@wintersunchem.com
Country
United States
ProdList
776
Advantage
68
Advance Scientific & Chemical
Tel
--
Fax
--
Email
sales@advance-scientific.com
Country
United States
ProdList
6419
Advantage
71
AK Scientific, Inc.
Tel
--
Fax
--
Email
sales@aksci.com
Country
United States
ProdList
6347
Advantage
65
AcceleDev Chemical LLC
Tel
--
Fax
--
Email
info@acceledev.com
Country
United States
ProdList
632
Advantage
42
American Custom Chemicals Corporation
Tel
--
Fax
--
Email
sales@acccorporation.com
Country
United States
ProdList
6820
Advantage
51
BOSCHE SCIENTIFIC, LLC
Tel
--
Fax
--
Email
Sales@BoscheSci.com
Country
United States
ProdList
6477
Advantage
55
Spectrum Chemicals & Laboratory Products
Tel
--
Fax
--
Email
sales@spectrumchemical.com
Country
United States
ProdList
6699
Advantage
77
MP Biomedicals, Inc.
Tel
--
Fax
--
Country
United States
ProdList
6561
Advantage
81
City Chemicals Corporation
Tel
--
Fax
--
Country
United States
ProdList
6460
Advantage
72
Deepwater Chemicals, Inc.
Tel
--
Fax
--
Email
psclem@deepwaterchemicals.com
Country
United States
ProdList
46
Advantage
51
George Uhe Co., Inc.
Tel
--
Fax
--
Email
global@uhe.com
Country
United States
ProdList
520
Advantage
65
Wilshire Chemical Company Inc.
Tel
--
Fax
--
Email
WilshrChem@AOL.COM
Country
United States
ProdList
3498
Advantage
58
ASDI Incorporated
Tel
--
Fax
--
Email
customerservice@asdi.net
Country
United States
ProdList
6922
Advantage
67
Magical Scientific LLP
Tel
--
Fax
--
Country
United States
ProdList
750
Advantage
43
More
Less

View Lastest Price from 4-Iodophenol manufacturers

Hebei Yanxi Chemical Co., Ltd.
Product
4-Iodophenol 540-38-5
Price
US $0.00/kg
Min. Order
1kg
Purity
99.00%
Supply Ability
20tons
Release date
2023-09-19
Henan Fengda Chemical Co., Ltd
Product
4-Iodophenol 540-38-5
Price
US $100.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-24
Zhuozhou Wenxi import and Export Co., Ltd
Product
4-Iodophenol 540-38-5
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-11

540-38-5, 4-IodophenolRelated Search:

SODIUM PHENOLATE TRIHYDRATE p-Cresol 4-tert-Butylphenol 4-Chlorophenol 2-Aminophenol 2-Phenylphenol Phenol 4-Fluorophenol 4-Iodophenoxyacetic acid Acetaminophen 4-Aminophenol 4-Nitrophenol 5-Iodosalicylic acid 3,5-DIIODOSALICYLALDEHYDE 5,7-Diiodo-8-quinolinol 5-IODO-O-VANILLIN METHYL 5-IODOSALICYLATE ERYTHROSIN B

  • 4-hydroxyiodobenzene
  • 4-hydroxyphenyliodide
  • 4-iodo-pheno
  • Phenol, p-iodo-
  • p-hydroxyiodobenzene
  • p-iodo-pheno
  • I**4-Iodophenol
  • P-IODOPHENOL
  • PHENOL, 4-IODO-
  • 4-IODOPHENOL
  • p-Iodophenol 4-Iodophenol
  • 4-Iodophenol99%
  • 4-Iodophenol, 98+%
  • PARA-IODOPHENOL
  • p-hydroxyiodobenzen
  • p-Jodphenol
  • Phenol to iodine
  • 4-Iodophenol, 99% 10GR
  • 4-Iodophenol, 99% 25GR
  • 4-Iodophenol [for BiocheMical Research]
  • 4-Iodophenol&gt
  • 4-Iodophenol[forBiochemicalResearch]&gt
  • 4-lodophenoI
  • 4-Iodophenol, ≥ 98.0%
  • 540-38-5
  • 129681-40-2
  • C6H5IO
  • ALCOHOL
  • Building Blocks
  • Organic Building Blocks
  • Oxygen Compounds
  • Phenols
  • Pyridines
  • Building Blocks
  • C6 to C8
  • Chemical Synthesis
  • Organic Building Blocks
  • Oxygen Compounds
  • Aromatic Phenols
  • Phenol&Thiophenol&Mercaptan
  • Phenoles and thiophenoles
  • Heterocyclic Compounds
  • Organic Building Blocks
  • Oxygen Compounds
  • Phenols