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Polydatin

Product Name
Polydatin
CAS No.
65914-17-2
Chemical Name
Polydatin
Synonyms
PICEID;Polydatin;Polydatain;Polydatine;(E/Z)-Piceid;Polydatin 98%;Polydatin ,98%;(Z/E-)-Polydatin;Polydatin(Piceid);RESVERATROL GLUCOSIDE
CBNumber
CB8328919
Molecular Formula
C20H22O8
Formula Weight
390.38
MOL File
65914-17-2.mol
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Polydatin Property

Melting point:
223-226 °C(lit.)
alpha 
-55 º (c=1,acetone)
Boiling point:
707.7±60.0 °C(Predicted)
Density 
1.521±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO (Slightly), Ethanol (Sparingly), Methanol (Slightly), Water (Slightly)
pka
9.31±0.10(Predicted)
form 
White to off-white solid.
color 
White to off-white solid.
optical activity
[α]20/D 55°, c = 1 in acetone
BRN 
54837
LogP
0.412 (est)
CAS DataBase Reference
65914-17-2(CAS DataBase Reference)
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
HS Code 
29389090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
15721
Product name
Polydatin
Purity
≥95% (HPLC)
Packaging
25g
Price
$311
Updated
2024/03/01
Sigma-Aldrich
Product number
1546194
Product name
Polydatin
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
20mg
Price
$406
Updated
2024/03/01
Cayman Chemical
Product number
21246
Product name
Polydatin
Purity
≥98%
Packaging
1g
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
21246
Product name
Polydatin
Purity
≥98%
Packaging
5g
Price
$118
Updated
2024/03/01
Sigma-Aldrich
Product number
572691
Product name
3,4′-5-Trihydroxystilbene-3-β-D-glucopyranoside
Purity
97%
Packaging
1g
Price
$259
Updated
2023/06/20
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Polydatin Chemical Properties,Usage,Production

Description

Polydatin (PD) is a major chemical component of Polygonum cuspidatum and it could also be found in a variety of other sources. PD is a polyphenol belonging to the chemical family of stilbenoids. Previous studies have shown that PD exhibits many pharmacological activities, including cardioprotective, neuroprotective, and antioxidative activities. With vascular dementia (VaD) rat models, PD markedly attenuated cognitive deficits. Biochemical analysis revealed that PD decreased the production of malondialdehyde (MDA) and significantly increased superoxide dismutase and catalase activities. Additionally, PD effectively alleviated the injuries of cultured neurons induced by oxygen–glucose deprivation. The therapeutic potential of PD for VaD seems related to its antioxidative activity and the direct protection of neurons. Furthermore, PD could also effectively inhibit the polymerization of amyloid-β peptides, which is a major mark in the progression of pathogenesis in Alzheimer’s disease (AD). These results suggest that PD is a promising drug candidate or nutraceutical for the treatment of VaD and AD.

Description

3,4′-5-Trihydroxystilbene-3-β-D-glucopyranoside is a stilbene glucoside that has been found in V. vinifera and has diverse biological activities. It reduces the growth of SKOV3 ovarian cancer cell 3D aggregates in a concentration-dependent manner. 3,4′-5-Trihydroxystilbene-3-β-D-glucopyranoside (10 and 20 μg/ml) inhibits IL-17 production in activated peripheral blood mononuclear cells (PBMCs). It inhibits the loss of glutathione peroxidase 4 (GPX4) activity induced by the ferroptosis inducer hemin in Neuro2a neuroblastoma cells. 3,4′-5-Trihydroxystilbene-3-β-D-glucopyranoside (50 mg/kg) reduces escape latency in a rat model of vascular dementia induced by four-vessel occlusion (4-VO).

Uses

Polydatin, a type of polyphenolic phytoalexin, has many physiological and pharmacological effects including anti-inflammatory and anti-oxidative activities. Polydatin is an effective candidate drug for the protection of photo-inflammation. Polydatin exhibits therapeutic potential for vascular dementia, most likely due to its anti-oxidant activity and the direct protection of neurons.

Uses

Trans-piceid is a stilbenoid that is trans-resveratrol substituted at position 3 by a beta-D-glucosyl residue. It has a role as a metabolite, a potassium channel modulator, an anti-arrhythmia drug, a hepatoprotective agent, an antioxidant and a nephroprotective agent. It is a stilbenoid, a polyphenol, a beta-D-glucoside and a monosaccharide derivative. It derives from a trans-resveratrol.

Uses

Polydatin is a Resveratrol glycoside and inhibitor of platelet aggregation.

Definition

ChEBI: Trans-piceid is a stilbenoid that is trans-resveratrol substituted at position 3 by a beta-D-glucosyl residue. It has a role as a metabolite, a potassium channel modulator, an anti-arrhythmia drug, a hepatoprotective agent, an antioxidant, a nephroprotective agent and a geroprotector. It is a stilbenoid, a polyphenol, a beta-D-glucoside and a monosaccharide derivative. It is functionally related to a trans-resveratrol.

Biological Functions

Stilbene found in medicinal herbs. Antioxidant, anti-inflammatory and neuroprotective.

Biological Activity

Polydatin is a natural stilbene originally isolated from the rhizome of P. cuspidatum, which is used in traditional Chinese medicine for analgesic, antipyretic, and diuretic effects.Like other stilbenes, this resveratrol glucoside has antioxidant activity.Polydatin has diverse effects in cells, tissues, and animals, including reducing cytotoxicity, inflammation, and atherosclerosis.

Biochem/physiol Actions

Stilbene found in medicinal herbs. Antioxidant, anti-inflammatory and neuroprotective.

Clinical Use

Polydatin (PD, also named pieceid, (E)-piceid, (E)-polydatin, trans-polydatin, 3,40 ,5-trihydroxystilbene-3-b-D-glucoside) is a monocrystalline compound originally isolated from the root and rhizome of Polygonum cuspidatum Sieb. et Zucc. (Polygonaceae), a traditional Chinese medicine that has long been used in China as an analgesic, anti-pyretic, diuretic and expectorant. It is a glucoside of resveratrol (3,40 ,5-trihydroxystilbene) in which the glucoside group bound to the position C-3 substitutes a hydroxyl group, belonging to stilbene phytoalexins. Polydatin can also be detected in grape, peanut, hop cones, red wines, hop pellets, cocoa-containing products, chocolate products and many daily diets. Polydatin is the most abundant form of resveratrol in nature. Polydatin shows many pharmacological effects confirmed by numerous investigations, including cardiovascular protection, neuroprotection, anti-inflammation, immunoregulation, anti-oxidation, anti-tumour and liver and lung protective effects. Polydatin has found its way into clinical trials for the treatment of hemorrhagic shock and irritable bowel syndrome.

Polydatin Preparation Products And Raw materials

Raw materials

Preparation Products

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Polydatin Suppliers

Changsha Hepu Biological Technology Co. Ltd
Tel
0731-88202122 13187036806
Fax
13187036806
Email
328078659@qq.com
Country
China
ProdList
60
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58
INTATRADE GmbH
Tel
+49 3493/605464
Fax
+49 3493/605470
Email
sales@intatrade.de
Country
Germany
ProdList
3572
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66
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6005
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61
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028 13552068683
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12390
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60
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527768850
Email
1791901229@qq.com
Country
China
ProdList
8843
Advantage
52
China Langchem Inc.
Tel
0086-21-58956006
Fax
0086-21-58956100
Country
China
ProdList
7811
Advantage
57
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9815
Advantage
79
Aktin Chemicals, Inc.
Tel
86-28-85159085
Fax
86-28-85152372
Email
info@aktinchem.com
Country
China
ProdList
297
Advantage
62
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
14055
Advantage
65
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View Lastest Price from Polydatin manufacturers

Shaanxi Haibo Biotechnology Co., Ltd
Product
Polydatin 65914-17-2
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
1%-98%
Supply Ability
50000kg/Month
Release date
2023-09-11
Hebei Lunzhi Import and Export Trade CO.,LLT
Product
Pharmaceutical Chemical Polydatin CAS 65914-17-2 65914-17-2
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20tons
Release date
2022-12-02
Career Henan Chemical Co
Product
Polydatin 65914-17-2
Price
US $1.00/kg
Min. Order
1kg
Purity
97%-99%
Supply Ability
as request
Release date
2018-12-23

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