ChemicalBook > CAS DataBase List > Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]-
Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]-
- Product Name
- Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]-
- CAS No.
- 5184-64-5
- Chemical Name
- Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]-
- Synonyms
- ESI-05;NSC 116966;ESI-05 (ESI05);ESI-05 (NSC 116966);ESI-05 >=98% (HPLC);MESITYL P-TOLYL SULFONE;1,3,5-trimethyl-2-tosylbenzene;1,3,5-Trimethyl-2-[(4-methylphenyl)sulfonyl]benzene;Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]-;Diacylglycerol acyltransferase,diabetes,Inhibitor,inhibit,Intracranial hemorrhage (ICH),Acyltransferase,cAMP,acyl-CoA:cholesterol acyltransferase,NSC116966,insulin secretion,mono- acylglycerol acyltransferase,exchange proteins directly activated by cAMP 2 (EPAC2),neurological disorders,NSC-116966,GEF,Diglyceride acyltransferase,ESI 05,ESI-05,ESI05
- CBNumber
- CB83290819
- Molecular Formula
- C16H18O2S
- Formula Weight
- 274.38
- MOL File
- 5184-64-5.mol
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Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]- Property
- Melting point:
- 119-120 °C
- Boiling point:
- 426.7±45.0 °C(Predicted)
- Density
- 1.129±0.06 g/cm3(Predicted)
- storage temp.
- room temp
- solubility
- DMSO: soluble
- form
- powder
- color
- white to beige
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- SML1907
- Product name
- ESI-05
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $105
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- SML1907
- Product name
- ESI-05
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $424
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- S798975
- Product name
- MESITYL P-TOLYL SULFONE
- Purity
- AldrichCPR
- Packaging
- 50MG
- Price
- $179
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 29702
- Product name
- ESI-05
- Packaging
- 5mg
- Price
- $93
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 29702
- Product name
- ESI-05
- Packaging
- 25mg
- Price
- $343
- Updated
- 2024/03/01
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Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]- Chemical Properties,Usage,Production
Uses
ESI-05 has been used to study the effect of protein exchange directly activated by cAMP 2 on traumatic brain injury.
Biochem/physiol Actions
ESI-05 is a selective inhibitor against cAMP-regulated guanine nucleotide exhange factor (GEF) EPAC2 (Exchange factor directly activated by cAMP 2) activation by targeting an EPAC2-specific allosteric site at the interface of the two cAMP-binding domains. ESI-05 inhibits EAPC2, but not EPAC1 or PKA, activation by cAMP in a highly potent (IC50 = 430 nM; 25 μM cAMP) and cAMP-competitive manner in cell-free assays, and suppresses cAMP analog 007-AM-induced cellular Rap1 activation in EPAC2-, but not EPAC1-, expressing HEK293 transfectants.
storage
Store at RT
Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]- Preparation Products And Raw materials
Raw materials
Preparation Products
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Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]- Suppliers
- Tel
- --
- Fax
- --
- customerservice@tocris.co.uk
- Country
- United Kingdom
- ProdList
- 5726
- Advantage
- 77