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Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]-

Product Name
Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]-
CAS No.
5184-64-5
Chemical Name
Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]-
Synonyms
ESI-05;NSC 116966;ESI-05 (ESI05);ESI-05 (NSC 116966);ESI-05 >=98% (HPLC);ESI-05, 10 mM in DMSO;MESITYL P-TOLYL SULFONE;1,3,5-trimethyl-2-tosylbenzene;1,3,5-Trimethyl-2-[(4-methylphenyl)sulfonyl]benzene;Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]-
CBNumber
CB83290819
Molecular Formula
C16H18O2S
Formula Weight
274.38
MOL File
5184-64-5.mol
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Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]- Property

Melting point:
119-120 °C
Boiling point:
426.7±45.0 °C(Predicted)
Density 
1.129±0.06 g/cm3(Predicted)
storage temp. 
room temp
solubility 
DMSO: soluble
form 
powder
color 
white to beige
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1907
Product name
ESI-05
Purity
≥98% (HPLC)
Packaging
5mg
Price
$91.8
Updated
2025/07/31
Sigma-Aldrich
Product number
SML1907
Product name
ESI-05
Purity
≥98% (HPLC)
Packaging
25mg
Price
$371
Updated
2025/07/31
Sigma-Aldrich
Product number
S798975
Product name
MESITYL P-TOLYL SULFONE
Purity
AldrichCPR
Packaging
50MG
Price
$185
Updated
2025/07/31
Cayman Chemical
Product number
29702
Product name
ESI-05
Packaging
5mg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
29702
Product name
ESI-05
Packaging
25mg
Price
$343
Updated
2024/03/01
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Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]- Chemical Properties,Usage,Production

Uses

ESI-05 has been used to study the effect of protein exchange directly activated by cAMP 2 on traumatic brain injury.

Biochem/physiol Actions

ESI-05 is a selective inhibitor against cAMP-regulated guanine nucleotide exhange factor (GEF) EPAC2 (Exchange factor directly activated by cAMP 2) activation by targeting an EPAC2-specific allosteric site at the interface of the two cAMP-binding domains. ESI-05 inhibits EAPC2, but not EPAC1 or PKA, activation by cAMP in a highly potent (IC50 = 430 nM; 25 μM cAMP) and cAMP-competitive manner in cell-free assays, and suppresses cAMP analog 007-AM-induced cellular Rap1 activation in EPAC2-, but not EPAC1-, expressing HEK293 transfectants.

in vivo

ESI-05 (2, 4, and 8 mg/kg) decreases neuronal apoptosis by inhibiting the p38/BIM pathway in vivo[2].

Animal Model:Intracranial hemorrhage (ICH) model[2]
Dosage:2, 4, and 8 mg/kg
Administration:
Result:Decreased the apoptosis rate of nerve cells in the cortex accompanied by a corresponding decrease in the protein expression of phosphorylated p38, Bcl-2like protein 11 (BIM), and caspase-3.

storage

Store at RT

Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

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Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]- Suppliers

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5184-64-5, Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]-Related Search:


  • Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]-
  • 1,3,5-Trimethyl-2-[(4-methylphenyl)sulfonyl]benzene
  • MESITYL P-TOLYL SULFONE
  • ESI-05
  • ESI-05 (ESI05)
  • 1,3,5-trimethyl-2-tosylbenzene
  • NSC 116966
  • ESI-05 >=98% (HPLC)
  • ESI-05 (NSC 116966)
  • Diacylglycerol acyltransferase,diabetes,Inhibitor,inhibit,Intracranial hemorrhage (ICH),Acyltransferase,cAMP,acyl-CoA:cholesterol acyltransferase,NSC116966,insulin secretion,mono- acylglycerol acyltransferase,exchange proteins directly activated by cAMP 2 (EPAC2),neurological disorders,NSC-116966,GEF,Diglyceride acyltransferase,ESI 05,ESI-05,ESI05
  • ESI-05, 10 mM in DMSO
  • 5184-64-5