AU1235

Product Name: AU1235
CAS No.: 1338780-86-1
Chemical Name: AU1235
Synonyms: AU1235;AU1235, 10 mM in DMSO;AU1235;AU-1235;AU 1235;1-(Adamantan-1-yl)-3-(2,3,4-trifluorophenyl)urea;Urea, N-tricyclo[3.3.1.13,7]dec-1-yl-N'-(2,3,4-trifluorophenyl)-;Inhibitor,MmpL3,transport,tuberculosis,AU1235,cell,AU 1235,AU-1235,synthesis,inhibit,Bacterial,wall,Mycobacterium
CBNumber: CB83309531
Molecular Formula: C17H19F3N2O
Formula Weight: 324.34
MOL File: 1338780-86-1.mol

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AU1235 Property

Boiling point:: 377.7±42.0 °C(Predicted)
Density: 1.33±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 6 mg/mL (18.50 mM)
pka: 12.02±0.70(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-6863
Product name: AU1235
Purity: 99.18%
Packaging: 2mg
Price: $132
Updated: 2021/12/16

ChemScene

Product number: CS-6863
Product name: AU1235
Purity: 99.18%
Packaging: 5mg
Price: $264
Updated: 2021/12/16

ChemScene

Product number: CS-6863
Product name: AU1235
Purity: 99.18%
Packaging: 10mg
Price: $420
Updated: 2021/12/16

ChemScene

Product number: CS-6863
Product name: AU1235
Purity: 99.18%
Packaging: 25mg
Price: $900
Updated: 2021/12/16

ChemScene

Product number: CS-6863
Product name: AU1235
Purity: 99.18%
Packaging: 50mg
Price: $1440
Updated: 2021/12/16

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AU1235 Chemical Properties,Usage,Production

Uses

AU1235, an adamantyl urea, is a potent MmpL3 inhibitor. The Mycobacterium tuberculosis protein MmpL3 performs an essential role in cell wall synthesis, since it effects the transport of trehalose monomycolates across the inner membrane[1][2].

References

[1] McNeil MB, et al. Multiple Mutations in Mycobacterium tuberculosis MmpL3 Increase Resistance to MmpL3 Inhibitors. mSphere. 2020;5(5):e00985-20. Published 2020 Oct 14. DOI:10.1128/mSphere.00985-20
[2] Grzegorzewicz AE, et al. Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane. Nat Chem Biol. 2012;8(4):334-341. Published 2012 Feb 19. DOI:10.1038/nchembio.794

AU1235 Preparation Products And Raw materials

Raw materials

Preparation Products

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AU1235 Suppliers

China 36 United States 6 Global 42

BOC Sciences

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1338780-86-1, AU1235Related Search:

AU1235

AU1235;AU-1235;AU 1235

Urea, N-tricyclo[3.3.1.13,7]dec-1-yl-N'-(2,3,4-trifluorophenyl)-

Inhibitor,MmpL3,transport,tuberculosis,AU1235,cell,AU 1235,AU-1235,synthesis,inhibit,Bacterial,wall,Mycobacterium

AU1235, 10 mM in DMSO

1-(Adamantan-1-yl)-3-(2,3,4-trifluorophenyl)urea

1338780-86-1