2-METHYLPYRIDINE-4-BORONIC ACID PINACOL ESTER
- Product Name
- 2-METHYLPYRIDINE-4-BORONIC ACID PINACOL ESTER
- CAS No.
- 660867-80-1
- Chemical Name
- 2-METHYLPYRIDINE-4-BORONIC ACID PINACOL ESTER
- Synonyms
- CAS:660867-80-1;2-Methylpyridine-4-;2-aMino-4-pyridine boronic ester;2-Picoline-4-boronic acid pinacolate;2-Picoline-4-boronic acid pinacol ester;2-Methylpyridine-4-boronic acid pinacol;2-METHYLPYRIDINE-4-BORONIC ACID PINACOL ESTER;2-Methyl-4-pyridineboronic acid pinacol ester;2-methyl-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine;2-(2-Methyl-4-pyridyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
- CBNumber
- CB8332208
- Molecular Formula
- C12H18BNO2
- Formula Weight
- 219.09
- MOL File
- 660867-80-1.mol
2-METHYLPYRIDINE-4-BORONIC ACID PINACOL ESTER Property
- Melting point:
- 66-71°C
- Boiling point:
- 315.9±30.0 °C(Predicted)
- Density
- 1.02
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- 5.11±0.10(Predicted)
- color
- White to Almost white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- CDS007583
- Product name
- 2-methylpyridine-4-boronic acid pinacol ester
- Purity
- Aldrich<SUP>CPR</SUP>
- Packaging
- 500 mg
- Price
- $107
- Updated
- 2025/07/31
- Product number
- M2867
- Product name
- 2-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
- Purity
- >98.0%(T)
- Packaging
- 1g
- Price
- $146
- Updated
- 2025/07/31
- Product number
- M2867
- Product name
- 2-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
- Purity
- >98.0%(T)
- Packaging
- 5g
- Price
- $583
- Updated
- 2025/07/31
- Product number
- X0928
- Product name
- 2-Methylpyridine-4-boronicacidpinacolester
- Packaging
- 10g
- Price
- $321
- Updated
- 2021/12/16
- Product number
- 8H60-1-6M
- Product name
- 2-Methylpyridine-4-boronic acid, pinacol ester
- Packaging
- 5G
- Price
- $160
- Updated
- 2021/12/16
2-METHYLPYRIDINE-4-BORONIC ACID PINACOL ESTER Chemical Properties,Usage,Production
Synthesis
22282-99-1
73183-34-3
660867-80-1
The general procedure for the synthesis of 2-methyl-4-pyridylboronic acid pinacol ester from 4-bromo-2-methylpyridine (0.500 g, 2.906 mmol) and pinacol ester of bis(diphenylphosphine) (0.812 g, 3.997 mmol) is as follows: in an inert atmosphere, 4-bromo-2-methylpyridine, pinacol ester of bis(boronic acid), potassium acetate (0.854 g, 8.720 mmol) and [1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloride (0.021 g, 0.029 mmol) were dissolved in degassed 1,4-dioxane (5 mL) in a 50 mL sealed tube. The reaction mixture was stirred at 80 °C for 4 hours. Upon completion of the reaction, the solvent was removed by rotary evaporation and the crude product was purified by silica gel column chromatography (eluent: ethyl acetate/ether = 30:70) to afford 2-methyl-4-pyridinylboronic acid pinacol ester (0.250 g, 39% yield) as an off-white solid. m/z 220.1 [M + H]+ was shown by LCMS analysis.
References
[1] Patent: WO2014/111871, 2014, A1. Location in patent: Page/Page column 199
[2] Patent: WO2004/14913, 2004, A2. Location in patent: Page 82
[3] Patent: US2011/190269, 2011, A1. Location in patent: Page/Page column 36
[4] Patent: WO2011/92272, 2011, A1. Location in patent: Page/Page column 73
[5] Patent: WO2011/119518, 2011, A1. Location in patent: Page/Page column 47-48
2-METHYLPYRIDINE-4-BORONIC ACID PINACOL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-METHYLPYRIDINE-4-BORONIC ACID PINACOL ESTER manufacturers
- Product
- 2-METHYLPYRIDINE-4-BORONIC ACID PINACOL ESTER 660867-80-1
- Price
- US $36.00-1.10/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-08
- Product
- 2-METHYLPYRIDINE-4-BORONIC ACID PINACOL ESTER 660867-80-1
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-26
- Product
- 2-METHYLPYRIDINE-4-BORONIC ACID PINACOL ESTER 660867-80-1
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-01-13