MAK-683
- Product Name
- MAK-683
- CAS No.
- 1951408-58-4
- Chemical Name
- MAK-683
- Synonyms
- MAK-683;CPD 1111;EED inhibitor-1;MAK 683;MAK-683;MAK683;MAK683,EED inhibitor-1;inhibit,MAK683,MAK-683,Inhibitor,Histone Methyltransferase,MAK 683;N-[(5-FLUORO-2,3-DIHYDROBENZOFURAN-4-YL)METHYL]-8-(2-METHYL-3-PYRIDYL)-[1,2,4]TRIAZOLO[4,3-C]PYRIMID;N-[(5-Fluoro-2,3-dihydro-4-benzofuranyl)methyl]-8-(2-methyl-3-pyridinyl)-1,2,4-triazolo[4,3-c]pyrimidin-5-amine;N-((5-Fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-(2-methylpyridin-3-yl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine;1,2,4-Triazolo[4,3-c]pyrimidin-5-amine, N-[(5-fluoro-2,3-dihydro-4-benzofuranyl)methyl]-8-(2-methyl-3-pyridinyl)-
- CBNumber
- CB83334085
- Molecular Formula
- C20H17FN6O
- Formula Weight
- 376.39
- MOL File
- 1951408-58-4.mol
MAK-683 Property
- Density
- 1.47±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 15 mg/ml
- form
- A solid
- pka
- 2.70±0.12(Predicted)
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 29316
- Product name
- MAK-683
- Packaging
- 1mg
- Price
- $81
- Updated
- 2024/03/01
- Product number
- 29316
- Product name
- MAK-683
- Packaging
- 10mg
- Price
- $593
- Updated
- 2024/03/01
- Product number
- 29316
- Product name
- MAK-683
- Packaging
- 5mg
- Price
- $336
- Updated
- 2024/03/01
- Product number
- M198120
- Product name
- MAK-683
- Packaging
- 1mg
- Price
- $85
- Updated
- 2021/12/16
- Product number
- CS-8054
- Product name
- MAK683
- Purity
- 98.05%
- Packaging
- 5mg
- Price
- $130
- Updated
- 2021/12/16
MAK-683 Chemical Properties,Usage,Production
Description
MAK-683 is an inhibitor of trimethylation of histone 3 lysine 27 (H3K27) by polycomb repressive complex 2 (PRC2), a complex that includes embryonic ectoderm development protein (EED). MAK-683 has an IC50 value of 5.9 nM in an EED-H3K27me3 peptide competition binding assay and inhibits H3K27 trimethylation in G401 cells (IC50 = 2.6 nM). It inhibits proliferation of KARPAS422 B cell lymphoma cells with an IC50 value of 3 nM.
Uses
MAK-683 is a useful intermediate for the preparation of triazolopyrimidine compounds useful in the treatment of diseases or disorders mediated by EED and/or PRC2. EED inhibitor-1.
MAK-683 Preparation Products And Raw materials
Raw materials
Preparation Products
MAK-683 Suppliers
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