MAK-683

Product Name: MAK-683
CAS No.: 1951408-58-4
Chemical Name: MAK-683
Synonyms: MAK-683;CPD 1111;EED inhibitor-1;MAK 683;MAK-683;MAK683;MAK683,EED inhibitor-1;inhibit,MAK683,MAK-683,Inhibitor,Histone Methyltransferase,MAK 683;N-[(5-FLUORO-2,3-DIHYDROBENZOFURAN-4-YL)METHYL]-8-(2-METHYL-3-PYRIDYL)-[1,2,4]TRIAZOLO[4,3-C]PYRIMID;N-[(5-Fluoro-2,3-dihydro-4-benzofuranyl)methyl]-8-(2-methyl-3-pyridinyl)-1,2,4-triazolo[4,3-c]pyrimidin-5-amine;1,2,4-Triazolo[4,3-c]pyrimidin-5-amine, N-[(5-fluoro-2,3-dihydro-4-benzofuranyl)methyl]-8-(2-methyl-3-pyridinyl)-
CBNumber: CB83334085
Molecular Formula: C20H17FN6O
Formula Weight: 376.39
MOL File: 1951408-58-4.mol

More

Less

MAK-683 Property

Density: 1.47±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 15 mg/ml
form: A solid
pka: 2.70±0.12(Predicted)

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 29316
Product name: MAK-683
Packaging: 1mg
Price: $81
Updated: 2024/03/01

Cayman Chemical

Product number: 29316
Product name: MAK-683
Packaging: 10mg
Price: $593
Updated: 2024/03/01

Cayman Chemical

Product number: 29316
Product name: MAK-683
Packaging: 5mg
Price: $336
Updated: 2024/03/01

TRC

Product number: M198120
Product name: MAK-683
Packaging: 1mg
Price: $85
Updated: 2021/12/16

ChemScene

Product number: CS-8054
Product name: MAK683
Purity: 98.05%
Packaging: 5mg
Price: $130
Updated: 2021/12/16

More

Less

MAK-683 Chemical Properties,Usage,Production

Description

MAK-683 is an inhibitor of trimethylation of histone 3 lysine 27 (H3K27) by polycomb repressive complex 2 (PRC2), a complex that includes embryonic ectoderm development protein (EED). MAK-683 has an IC₅₀ value of 5.9 nM in an EED-H3K27me3 peptide competition binding assay and inhibits H3K27 trimethylation in G401 cells (IC₅₀ = 2.6 nM). It inhibits proliferation of KARPAS422 B cell lymphoma cells with an IC₅₀ value of 3 nM.

Uses

MAK-683 is a useful intermediate for the preparation of triazolopyrimidine compounds useful in the treatment of diseases or disorders mediated by EED and/or PRC2. EED inhibitor-1.

MAK-683 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

MAK-683 Suppliers

China 54 United States 7 Global 61

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 14059
Advantage: 65

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3421
Advantage: 58

Shanghai XingMo Biotechnology Co., Ltd.

Tel: 13524779951
Fax: QQ: 2075692521
Email: 2075692521@qq.com
Country: China
ProdList: 309
Advantage: 55

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4153
Advantage: 55

NanJing Xienuo bio Co.,Ltd.

Tel: 025-84112752 13805181430
Fax: +86-25-84846489
Email: 154301870@qq.com
Country: China
ProdList: 994
Advantage: 55

ShangHai Biochempartner Co.,Ltd

Tel: 17754423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8013
Advantage: 62

Shanghai Chaolan Chemical Technology Center

Tel: QQ:65489617 15618227136
Fax: 21-5161 9052
Email: info@SuperLan-chem.com
Country: China
ProdList: 9737
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131981
Advantage: 58

Kaixin Chemical (Hong Kong) Limited

Tel: 010-88886666-01 13112345678
Fax: CDXH21@126.com
Email: loyson@tcypharm.com
Country: China
ProdList: 595
Advantage: 55

Shanghai Biopharmaleader Co., Ltd.

Tel: +86 18721201413
Fax: +86 (21) 5775-8967
Email: sales@biopharmaleader.com
Country: China
ProdList: 1720
Advantage: 58

1951408-58-4, MAK-683Related Search:

CPD 1111

MAK-683

EED inhibitor-1

MAK 683;MAK-683;MAK683

N-[(5-Fluoro-2,3-dihydro-4-benzofuranyl)methyl]-8-(2-methyl-3-pyridinyl)-1,2,4-triazolo[4,3-c]pyrimidin-5-amine

N-[(5-FLUORO-2,3-DIHYDROBENZOFURAN-4-YL)METHYL]-8-(2-METHYL-3-PYRIDYL)-[1,2,4]TRIAZOLO[4,3-C]PYRIMID

1,2,4-Triazolo[4,3-c]pyrimidin-5-amine, N-[(5-fluoro-2,3-dihydro-4-benzofuranyl)methyl]-8-(2-methyl-3-pyridinyl)-

inhibit,MAK683,MAK-683,Inhibitor,Histone Methyltransferase,MAK 683

MAK683,EED inhibitor-1

1951408-58-4