BCI-121
- Product Name
- BCI-121
- CAS No.
- 432529-82-3
- Chemical Name
- BCI-121
- Synonyms
- BCL 121;BCI-121;BCI-121;BCI 121;BCI121;1-Piperidineacetamide, 4-(aminocarbonyl)-N-(4-bromophenyl)-;1-{2-[(4-bromophenyl)amino]-2-oxoethyl}piperidine-4-carboxamide;inhibit,BCI 121,Histone Methyltransferase,Inhibitor,BCI-121,BCI121
- CBNumber
- CB83339611
- Molecular Formula
- C14H18BrN3O2
- Formula Weight
- 340.22
- MOL File
- 432529-82-3.mol
BCI-121 Property
- Boiling point:
- 576.1±50.0 °C(Predicted)
- Density
- 1.474±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMF:30.0(Max Conc. mg/mL);88.18(Max Conc. mM)
DMSO:66.0(Max Conc. mg/mL);193.99(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:2):0.33(Max Conc. mg/mL);0.97(Max Conc. mM)
Ethanol:39.0(Max Conc. mg/mL);114.63(Max Conc. mM) - pka
- 13.82±0.70(Predicted)
- form
- powder
- color
- white to beige
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML1817
- Product name
- BCI-121
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $114
- Updated
- 2024/03/01
- Product number
- SML1817
- Product name
- BCI-121
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $464
- Updated
- 2024/03/01
- Product number
- CS-B1554
- Product name
- BCI-121
- Purity
- 99.45%
- Packaging
- 5mg
- Price
- $72
- Updated
- 2021/12/16
- Product number
- CS-B1554
- Product name
- BCI-121
- Purity
- 99.45%
- Packaging
- 10mg
- Price
- $114
- Updated
- 2021/12/16
- Product number
- CS-B1554
- Product name
- BCI-121
- Purity
- 99.45%
- Packaging
- 25mg
- Price
- $234
- Updated
- 2021/12/16
BCI-121 Chemical Properties,Usage,Production
Biochem/physiol Actions
BCI-121 is a substrate-competitive SMYD3 inhibitor that reduces nuclear histone H3 lys4 di- and tri-methylation level (by 50%/H3K4me2 and 40%H3K4me3 in HT29 cells; 100 μM BCI-121 for 48 h), downregulates known SMYD3 target genes transcription, and selectively affects SMYD3-dependent proliferation of cancer cultures (46%/HT29 and 54%/HCT116 proliferation reduction; 100 μM BCI-121 for 72 h) with little antiproliferation efficacy toward low SMYD3-expressing cancer cells. BCI-121 targets SMYD3 via direct affinity interaction (kon 357.7/M/s; koff 4.23×10-3/s; KD=koff/kon = 11.8 μM) and effectively competes against histone for SMYD3 binding (%inhibition/[histone H4 peptide]:[BCI-121] ratio = 36.5%/1:1 and 51.0%/1:2.5).
BCI-121 Preparation Products And Raw materials
Raw materials
Preparation Products
BCI-121 Suppliers
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