ChemicalBook > CAS DataBase List > Autophinib

Autophinib

Product Name
Autophinib
CAS No.
1644443-47-9
Chemical Name
Autophinib
Synonyms
CS-2834;Autophinib;Autophinib, 10 mM in DMSO;Autophinib/1644443-47-9/98%;PI3K,inhibit,Autophagy,Autophinib,Phosphoinositide 3-kinase,Inhibitor;6-Chloro-N-(5-methyl-1H-pyrazol-3-yl)-2-(4-nitrophenoxy)-pyrimidinamine;6-CHLORO-N-(5-METHYL-1H-PYRAZOL-3-YL)-2-(4-NITROPHENOXY)PYRIMIDIN-4-AMINE;4-Pyrimidinamine, 6-chloro-N-(5-methyl-1H-pyrazol-3-yl)-2-(4-nitrophenoxy)-
CBNumber
CB83344886
Molecular Formula
C14H11ClN6O3
Formula Weight
346.73
MOL File
1644443-47-9.mol
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Autophinib Property

Boiling point:
640.6±65.0 °C(Predicted)
Density 
1.547±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility 
DMSO:13.98(Max Conc. mg/mL);40.32(Max Conc. mM)
form 
A solid
pka
13.78±0.10(Predicted)
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML2632
Product name
Autophinib
Purity
≥98% (HPLC)
Packaging
5MG
Price
$70
Updated
2025/07/31
Sigma-Aldrich
Product number
SML2632
Product name
Autophinib
Purity
≥98% (HPLC)
Packaging
25MG
Price
$406
Updated
2025/07/31
Cayman Chemical
Product number
27320
Product name
Autophinib
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
27320
Product name
Autophinib
Packaging
25mg
Price
$494
Updated
2024/03/01
Cayman Chemical
Product number
27320
Product name
Autophinib
Packaging
5mg
Price
$139
Updated
2024/03/01
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Autophinib Chemical Properties,Usage,Production

Uses

Autophinib is a potent VPS34 inhibitor (IC50 = 19 nM). Inhibits starvation- and Rapamycin-induced autophagy (IC50 values = 40 and 90 nM, respectively).

Biological Activity

Autophinib is an ATP-competitive, potent and selective PI3K type 3 lipid kinase vacuolar protein sorting 34 inhibitor (VPS34 IC50/[ATP] = 19 nM/10 μM & 51 nM/100 μM) th at shows significant inhibition against only 45 kinases among a panel of >460 with little or no potency toward mTOR, TBK1 and 12 other phosphatidylinositol kinases (=22% inhibition at 1 μM). Autophinib effectively prevents autophagy induction in MCF7 cells upon amino acid starvation or rapamycin treatment (IC50 = 40 nM and 19 nM, respectively) with similar potency as SAR405 (IC50 = 53 nM and 20 nM, respectively) and VPS34-IN1 (IC50 = 13 nM and 15 nM, respectively). Autophinib enhances MCF7 cell death under starvation condition (EC50 = 264 nM and 234 nM by cytotoxiciy and apoptosis detection, respectively) by preventing autophagy-dependent cell survival.

IC 50

Vps34: 19 nM (IC50)

storage

Store at +4°C

Autophinib Preparation Products And Raw materials

Raw materials

Preparation Products

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Autophinib Suppliers

China 81 India 1 United Kingdom 1 United States 10 Global 93
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1644443-47-9, AutophinibRelated Search:

N,N'-Ethylenebis(stearamide) Deionized water (2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride

  • Autophinib
  • 6-CHLORO-N-(5-METHYL-1H-PYRAZOL-3-YL)-2-(4-NITROPHENOXY)PYRIMIDIN-4-AMINE
  • 6-Chloro-N-(5-methyl-1H-pyrazol-3-yl)-2-(4-nitrophenoxy)-pyrimidinamine
  • CS-2834
  • 4-Pyrimidinamine, 6-chloro-N-(5-methyl-1H-pyrazol-3-yl)-2-(4-nitrophenoxy)-
  • PI3K,inhibit,Autophagy,Autophinib,Phosphoinositide 3-kinase,Inhibitor
  • Autophinib, 10 mM in DMSO
  • Autophinib/1644443-47-9/98%
  • 1644443-47-9