2,4,6-TRICHLOROQUINAZOLINE
Uses- Product Name
- 2,4,6-TRICHLOROQUINAZOLINE
- CAS No.
- 20028-68-6
- Chemical Name
- 2,4,6-TRICHLOROQUINAZOLINE
- Synonyms
- 2,4,6-trichlroquinazoline;2,4,6-TRICHLOROQUINOXALINE;2,4,6-TRICHLOROQUINAZOLINE;Quinazoline, 2,4,6-trichloro-;2,4,6-Trichloroquinazoline 98%
- CBNumber
- CB8335931
- Molecular Formula
- C8H3Cl3N2
- Formula Weight
- 233.48
- MOL File
- 20028-68-6.mol
2,4,6-TRICHLOROQUINAZOLINE Property
- Melting point:
- 131 °C
- Boiling point:
- 230-240 °C(Press: 15 Torr)
- Density
- 1.600±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -1.15±0.30(Predicted)
- Appearance
- White to light yellow Solid
Safety
- Hazard Codes
- T,Xi
- Risk Statements
- 25-37/38-41
- Safety Statements
- 26-36
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- T774723
- Product name
- 2,4,6-Trichloroquinazoline
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 3H32-5-3J
- Product name
- 2,4,6-Trichloroquinazoline
- Purity
- 98%
- Packaging
- 1g
- Price
- $248
- Updated
- 2021/12/16
- Product number
- 073943
- Product name
- 2,4,6-Trichloroquinazoline
- Purity
- 95+%
- Packaging
- 1g
- Price
- $250
- Updated
- 2021/12/16
- Product number
- W4235
- Product name
- 2,4,6-Trichloroquinazoline
- Packaging
- 5g
- Price
- $532
- Updated
- 2021/12/16
- Product number
- HCH0010726
- Product name
- 2,4,6-TRICHLOROQUINAZOLINE
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $862.79
- Updated
- 2021/12/16
2,4,6-TRICHLOROQUINAZOLINE Chemical Properties,Usage,Production
Uses
2,4,6-Trichloroquinazoline is a heterocyclic organic compound that can be used as a pharmaceutical intermediate.
Synthesis
1640-60-4
20028-68-6
Part C: Preparation of 2,4,6-trichloroquinazoline. 6-Chloro-2,4-quinazoline dione (3.27 g, 1.0 equiv) was suspended in 30 mL of phosphoryl chloride and 1.5 mL of N,N-dimethylaniline was added as a catalyst. The reaction mixture was heated to reflux and held for 4.5 hours. Upon completion of the reaction, the mixture was cooled to room temperature and then slowly poured into a pre-cooled (0°C) mixture of solvents (300 mL of diethyl ether with 300 mL of water). The organic layer was separated, washed with saturated sodium chloride solution and dried over anhydrous magnesium sulfate. After filtration, the solvent was removed by concentration under reduced pressure to give 3.54 g of brown to yellow solid product in 91% yield. The structure of the product was confirmed by 1H NMR (DMSO-d6, 300 MHz): δ 8.325 (m, 1H), 8.20 (m, 1H), 8.085 (m, 1H).
References
[1] Patent: US5187168, 1993, A
[2] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 24, p. 7717 - 7727
[3] Bioorganic and Medicinal Chemistry, 2003, vol. 11, # 11, p. 2439 - 2444
[4] Patent: WO2010/78449, 2010, A2. Location in patent: Page/Page column 235-236
[5] Scientia Sinica (English Edition), 1958, vol. 7, p. 617,628
2,4,6-TRICHLOROQUINAZOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,4,6-TRICHLOROQUINAZOLINE manufacturers
- Product
- 2,4,6-TRICHLOROQUINAZOLINE 20028-68-6
- Price
- US $8.80/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 100kg
- Release date
- 2019-07-09