ASTX660

Product Name: ASTX660
CAS No.: 1799328-86-1
Chemical Name: ASTX660
Synonyms: ASTX660;Tolinapant;ASTX660 (ASTX 660;ASTX660(Tolinapant）;Tolinapant (ASTX660);ASTX660, 10 mM in DMSO;Inhibitor,inhibit,ASTX-660,ASTX660,IAP,ASTX 660;1-(6-(4-Fluorobenzyl)-5-(hydroxymethyl)-3,3-dimethyl-2,3-dihydro-1H-pyrrolo[3,2-b]pyridin-1-yl)-2-((2R,5R)-5-methyl-2-(((R)-3-methylmorpholino)methyl)piperazin-1-yl)ethanone;1-[6-[(4-Fluorophenyl)methyl]-2,3-dihydro-5-(hydroxymethyl)-3,3-dimethyl-1H-pyrrolo[3,2-b]pyridin-1-yl]-2-[(2R,5R)-5-methyl-2-[[(3R)-3-methyl-4-morpholinyl]methyl]-1-piperazinyl]ethanone;Ethanone, 1-[6-[(4-fluorophenyl)methyl]-2,3-dihydro-5-(hydroxymethyl)-3,3-dimethyl-1H-pyrrolo[3,2-b]pyridin-1-yl]-2-[(2R,5R)-5-methyl-2-[[(3R)-3-methyl-4-morpholinyl]methyl]-1-piperazinyl]-
CBNumber: CB83368305
Molecular Formula: C30H42FN5O3
Formula Weight: 539.68
MOL File: 1799328-86-1.mol

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ASTX660 Property

Boiling point:: 716.6±60.0 °C(Predicted)
Density: 1.169±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:75.0(Max Conc. mg/mL);138.97(Max Conc. mM)
Ethanol:100.0(Max Conc. mg/mL);185.29(Max Conc. mM)
form: A solid
pka: 13.30±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: BA166845
Product name: ASTX 660
Packaging: 10mg
Price: $285
Updated: 2021/12/16

AK Scientific

Product number: 2550EF
Product name: 1-[6-[(4-Fluorophenyl)methyl]-5-(hydroxymethyl)-3,3-dimethyl-2H-pyrrolo[3,2-b]pyridin-1-yl]-2-[(2R,5R)-5-methyl-2-[[(3R)-3-methylmorpholin-4-yl]methyl]piperazin-1-yl]ethanone
Packaging: 10mg
Price: $434
Updated: 2021/12/16

DC Chemicals

Product number: DC20695
Product name: ASTX660(Tolinapant）
Purity: >98%
Packaging: 100mg
Price: $700
Updated: 2021/12/16

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ASTX660 Chemical Properties,Usage,Production

Uses

Tolinapant (ASTX660) is an orally bioavailable dual antagonist of cellular inhibitor of apoptosis protein (cIAP) and X-linked inhibitor of apoptosis protein (XIAP).

in vivo

In HCC1806 xenografts in mice, Tolinapant (daily oral treatment) causes moderate tumor growth inhibition but not regression^[1].

References

[1] Tomoko Smyth, et al. Abstract 1287: The dual IAP antagonist, ASTX660, increases the anti-tumor activity of NSC 125973 in preclinical models of triple-negative breast cancer in vivo. Cancer Res 2016;76(14 Suppl).

ASTX660 Preparation Products And Raw materials

Raw materials

Preparation Products

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ASTX660 Suppliers

China 76 United States 4 Global 80

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 15883
Advantage: 64

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3506
Advantage: 58

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4757
Advantage: 55

ShangHai Angti Biotechnology Co., Ltd.

Tel: 13764913901
Fax: -
Email: info@angtibio.com
Country: China
ProdList: 4985
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
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Shanghai Rechem science Co., Ltd.

Tel: 021-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
Country: China
ProdList: 2989
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ChengDu TongChuangYuan Pharmaceutical Co.Ltd

Tel: 028-83379370 13880556291
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Email: tcy@tcypharm.com
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Chuzhou KeMail Chemical Technology Co., Ltd

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Fax: 0550-5196001
Email: wj520wjxby@126.com
Country: China
ProdList: 1944
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Shanghai Linka Biotechnology Co., Ltd.

Tel: 18301977208
Fax: qq2126935757
Email: 2126935757@qq.com
Country: China
ProdList: 214
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View Lastest Price from ASTX660 manufacturers

Hubei Chuchang Biotech Co., Ltd.

Product: ASTX660 1799328-86-1
Price: US $0.00-0.00/MG
Min. Order: 1MG
Purity: 98
Supply Ability: 100G
Release date: 2024-04-17

1799328-86-1, ASTX660Related Search:

ASTX660 (ASTX 660

ASTX660

Ethanone, 1-[6-[(4-fluorophenyl)methyl]-2,3-dihydro-5-(hydroxymethyl)-3,3-dimethyl-1H-pyrrolo[3,2-b]pyridin-1-yl]-2-[(2R,5R)-5-methyl-2-[[(3R)-3-methyl-4-morpholinyl]methyl]-1-piperazinyl]-

ASTX660(Tolinapant）

1-(6-(4-Fluorobenzyl)-5-(hydroxymethyl)-3,3-dimethyl-2,3-dihydro-1H-pyrrolo[3,2-b]pyridin-1-yl)-2-((2R,5R)-5-methyl-2-(((R)-3-methylmorpholino)methyl)piperazin-1-yl)ethanone

Inhibitor,inhibit,ASTX-660,ASTX660,IAP,ASTX 660

Tolinapant

Tolinapant (ASTX660)

ASTX660, 10 mM in DMSO

1-[6-[(4-Fluorophenyl)methyl]-2,3-dihydro-5-(hydroxymethyl)-3,3-dimethyl-1H-pyrrolo[3,2-b]pyridin-1-yl]-2-[(2R,5R)-5-methyl-2-[[(3R)-3-methyl-4-morpholinyl]methyl]-1-piperazinyl]ethanone

1799328-86-1

C30H42FN5O3

API