ChemicalBook > CAS DataBase List > ASTX660
ASTX660
- Product Name
- ASTX660
- CAS No.
- 1799328-86-1
- Chemical Name
- ASTX660
- Synonyms
- ASTX660;Tolinapant;ASTX660 (ASTX 660;ASTX660(Tolinapant）;Tolinapant (ASTX660);ASTX660, 10 mM in DMSO;Inhibitor,inhibit,ASTX-660,ASTX660,IAP,ASTX 660;1-(6-(4-Fluorobenzyl)-5-(hydroxymethyl)-3,3-dimethyl-2,3-dihydro-1H-pyrrolo[3,2-b]pyridin-1-yl)-2-((2R,5R)-5-methyl-2-(((R)-3-methylmorpholino)methyl)piperazin-1-yl)ethanone;1-[6-[(4-Fluorophenyl)methyl]-2,3-dihydro-5-(hydroxymethyl)-3,3-dimethyl-1H-pyrrolo[3,2-b]pyridin-1-yl]-2-[(2R,5R)-5-methyl-2-[[(3R)-3-methyl-4-morpholinyl]methyl]-1-piperazinyl]ethanone;Ethanone, 1-[6-[(4-fluorophenyl)methyl]-2,3-dihydro-5-(hydroxymethyl)-3,3-dimethyl-1H-pyrrolo[3,2-b]pyridin-1-yl]-2-[(2R,5R)-5-methyl-2-[[(3R)-3-methyl-4-morpholinyl]methyl]-1-piperazinyl]-
- CBNumber
- CB83368305
- Molecular Formula
- C30H42FN5O3
- Formula Weight
- 539.68
- MOL File
- 1799328-86-1.mol
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ASTX660 Property
- Boiling point:
- 716.6±60.0 °C(Predicted)
- Density
- 1.169±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:75.0(Max Conc. mg/mL);138.97(Max Conc. mM)
Ethanol:100.0(Max Conc. mg/mL);185.29(Max Conc. mM) - form
- A solid
- pka
- 13.30±0.10(Predicted)
- color
- White to off-white
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Biosynth Carbosynth
- Product number
- BA166845
- Product name
- ASTX 660
- Packaging
- 10mg
- Price
- $285
- Updated
- 2021/12/16
AK Scientific
- Product number
- 2550EF
- Product name
- 1-[6-[(4-Fluorophenyl)methyl]-5-(hydroxymethyl)-3,3-dimethyl-2H-pyrrolo[3,2-b]pyridin-1-yl]-2-[(2R,5R)-5-methyl-2-[[(3R)-3-methylmorpholin-4-yl]methyl]piperazin-1-yl]ethanone
- Packaging
- 10mg
- Price
- $434
- Updated
- 2021/12/16
DC Chemicals
- Product number
- DC20695
- Product name
- ASTX660(Tolinapant）
- Purity
- >98%
- Packaging
- 100mg
- Price
- $700
- Updated
- 2021/12/16
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ASTX660 Chemical Properties,Usage,Production
Uses
Tolinapant (ASTX660) is an orally bioavailable dual antagonist of cellular inhibitor of apoptosis protein (cIAP) and X-linked inhibitor of apoptosis protein (XIAP).
in vivo
In HCC1806 xenografts in mice, Tolinapant (daily oral treatment) causes moderate tumor growth inhibition but not regression[1].
References
[1] Tomoko Smyth, et al. Abstract 1287: The dual IAP antagonist, ASTX660, increases the anti-tumor activity of NSC 125973 in preclinical models of triple-negative breast cancer in vivo. Cancer Res 2016;76(14 Suppl).
ASTX660 Preparation Products And Raw materials
Raw materials
Preparation Products
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ASTX660 Suppliers
- Tel
- +1-708-310-1919 +1-13798911105
- Fax
- 708-557-7486
- sales@invivochem.cn
- Country
- United States
- ProdList
- 6391
- Advantage
- 58
- Tel
- +1-781-999-5354;
- support@targetmol.com
- Country
- United States
- ProdList
- 39035
- Advantage
- 58
- Tel
- tp@aladdinsci.com
- Country
- United States
- ProdList
- 57505
- Advantage
- 58
- Tel
- --
- Fax
- --
- cayman@caymanchem.com
- Country
- United States
- ProdList
- 6213
- Advantage
- 81
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View Lastest Price from ASTX660 manufacturers
Hubei Chuchang Biotech Co., Ltd.
- Product
- ASTX660 1799328-86-1
- Price
- US $0.00-0.00/MG
- Min. Order
- 1MG
- Purity
- 98
- Supply Ability
- 100G
- Release date
- 2024-04-17