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RP-5063

Product Name
RP-5063
CAS No.
1239729-06-6
Chemical Name
RP-5063
Synonyms
RP5603;RP-5063;Brilaroxazine;Trolamine Impurity 11;Brilaroxazine, 10 mM in DMSO;2H-1,4-Benzoxazin-3(4H)-one, 6-[4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butoxy]-;6-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butoxy)-2H-benzo[b][1,4]oxazin-3(4H)-one;6-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}-3,4-dihydro-2H-1,4-benzoxazin-3-one;Dopamine Receptor,Parkinson,depressive,hypertension,cardiac,Brilaroxazine,RP 5063,syndrome,ADHD,autism,inhibit,Pulmonary,PAH,RP-5063,Serotonin Receptor,Alzheimer,5-HT Receptor,Inhibitor,disorder,Tourette,arterial,5-hydroxytryptamine Receptor
CBNumber
CB83372159
Molecular Formula
C22H25Cl2N3O3
Formula Weight
450.36
MOL File
1239729-06-6.mol
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RP-5063 Property

Boiling point:
643.0±55.0 °C(Predicted)
Density 
1.301±0.06 g/cm3(Predicted)
storage temp. 
4°C, protect from light
solubility 
DMSO : 100 mg/mL (222.04 mM; Need ultrasonic)
pka
12.36±0.20(Predicted)
form 
Solid
color 
Off-white to light yellow
InChI
InChI=1S/C22H25Cl2N3O3/c23-17-4-3-5-19(22(17)24)27-11-9-26(10-12-27)8-1-2-13-29-16-6-7-20-18(14-16)25-21(28)15-30-20/h3-7,14H,1-2,8-13,15H2,(H,25,28)
InChIKey
PMKMNTBZJOXTJW-UHFFFAOYSA-N
SMILES
O1C2=CC=C(OCCCCN3CCN(C4=CC=CC(Cl)=C4Cl)CC3)C=C2NC(=O)C1
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Hazard and Precautionary Statements (GHS)

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RP-5063 Chemical Properties,Usage,Production

Uses

Brilaroxazine was developed as a antipsychotic which may be effective in the treatment of schizophrenia and bipolar disorder.

in vivo

Brilaroxazine (oral gavage; 10 mg/kg; twice daily; 28 days) limits the functional and structural effects of pulmonary arterial hypertension (PAH), with significant improvements in pulmonary hemodynamics, right ventricular (RV) hypertrophy, SO2, and pulmonary blood vessel structural changes[1].

Animal Model:SD-rats[2]
Dosage:10 mg/kg
Administration:Oral gavage; twice daily; 28 days
Result:Had the efficacy in PAH, and mitigated the functional and structural effects of MCT-induced PAH.

IC 50

5-HT1A Receptor: 1.5 nM (Ki); 5-HT2A Receptor: 2.5 nM (Ki); 5-HT2B Receptor: 0.19 nM (Ki); 5-HT7 Receptor: 2.7 nM (Ki); D2 Receptor; D3 Receptor; D4 Receptor

RP-5063 Preparation Products And Raw materials

Raw materials

Preparation Products

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RP-5063 Suppliers

China 34 United States 4 Global 38
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
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58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
52923
Advantage
58
MedChemExpress
Tel
--
Fax
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Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58

1239729-06-6, RP-5063Related Search:


  • RP-5063
  • Brilaroxazine
  • Dopamine Receptor,Parkinson,depressive,hypertension,cardiac,Brilaroxazine,RP 5063,syndrome,ADHD,autism,inhibit,Pulmonary,PAH,RP-5063,Serotonin Receptor,Alzheimer,5-HT Receptor,Inhibitor,disorder,Tourette,arterial,5-hydroxytryptamine Receptor
  • 2H-1,4-Benzoxazin-3(4H)-one, 6-[4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butoxy]-
  • 6-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butoxy)-2H-benzo[b][1,4]oxazin-3(4H)-one
  • 6-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}-3,4-dihydro-2H-1,4-benzoxazin-3-one
  • Trolamine Impurity 11
  • RP5603
  • Brilaroxazine, 10 mM in DMSO
  • 1239729-06-6
  • APIS