(2S)-2-[(2S)-2-{[(tert-butoxy)carbonyl]amino}-3-methylbutanamido]-5-(carbamoylamino)pentanoic acid
- Product Name
- (2S)-2-[(2S)-2-{[(tert-butoxy)carbonyl]amino}-3-methylbutanamido]-5-(carbamoylamino)pentanoic acid
- CAS No.
- 870487-08-4
- Chemical Name
- (2S)-2-[(2S)-2-{[(tert-butoxy)carbonyl]amino}-3-methylbutanamido]-5-(carbamoylamino)pentanoic acid
- Synonyms
- Boc-Val-Cit;Boc-Val-Cit-OH;Boc-L-Val-Cit-OH;Boc-L-valyl-L-citrulline;N-Boc-L-valyl-N5-(aminocarbonyl)-L-ornithine;L-Ornithine, N-[(1,1-dimethylethoxy)carbonyl]-L-valyl-N5-(aminocarbonyl)-;(R)-2-((R)-2-((tert-butoxycarbonyl)amino)-3-methylbutanamido)-5-ureidopentanoic acid;ADC Linkers,Inhibitor,Boc Val Cit OH,BocValCitOH,Antibody-drug conjugates linkers,inhibit;(2S)-2-[[(2S)-2-(tert-butoxycarbonylamino)-3-methyl-butanoyl]amino]-5-ureido-pentanoic acid;(2S)-2-[(2S)-2-{[(tert-butoxy)carbonyl]amino}-3-methylbutanamido]-5-(carbamoylamino)pentanoic acid
- CBNumber
- CB83373136
- Molecular Formula
- C16H30N4O6
- Formula Weight
- 374.43
- MOL File
- 870487-08-4.mol
(2S)-2-[(2S)-2-{[(tert-butoxy)carbonyl]amino}-3-methylbutanamido]-5-(carbamoylamino)pentanoic acid Property
- Boiling point:
- 624.8±55.0 °C(Predicted)
- Density
- 1.183±0.06 g/cm3(Predicted)
- storage temp.
- Storage temp. 2-8°C
- solubility
- Soluble in DMSO
- pka
- 3.44±0.10(Predicted)
- form
- Solid
- color
- White to off-white
- InChIKey
- ZZLNUAVYYRBTOZ-QWRGUYRKSA-N
- SMILES
- C(O)(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](C(C)C)NC(OC(C)(C)C)=O
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P330Rinse mouth.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CS-0096160
- Product name
- Boc-Val-Cit-OH
- Purity
- ≥98.0%
- Packaging
- 100mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- CS-0096160
- Product name
- Boc-Val-Cit-OH
- Purity
- ≥98.0%
- Packaging
- 250mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- BP-24173
- Product name
- Boc-Val-Cit
- Purity
- 95%
- Packaging
- 1g
- Price
- $240
- Updated
- 2021/12/16
- Product number
- CS-0096160
- Product name
- Boc-Val-Cit-OH
- Purity
- ≥98.0%
- Packaging
- 1g
- Price
- $399
- Updated
- 2021/12/16
- Product number
- 181174
- Product name
- Boc-Val-Cit-OH
- Packaging
- 5g
- Price
- $400
- Updated
- 2021/12/16
(2S)-2-[(2S)-2-{[(tert-butoxy)carbonyl]amino}-3-methylbutanamido]-5-(carbamoylamino)pentanoic acid Chemical Properties,Usage,Production
Description
Boc-Val-Cit is a cleavable ADC linker. The Val-Cit will specifically be cleaved by Cathepsin B. Boc group can be removed under acidic condition.
Uses
Boc-Val-Cit-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
IC 50
Protease Cleavable Linker; Cleavable Linker
References
[1] Kevin HAMBLETT, et al. Anti-her2 biparatopic antibody-drug conjugates and methods of use. WO2019173911A1.
(2S)-2-[(2S)-2-{[(tert-butoxy)carbonyl]amino}-3-methylbutanamido]-5-(carbamoylamino)pentanoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
(2S)-2-[(2S)-2-{[(tert-butoxy)carbonyl]amino}-3-methylbutanamido]-5-(carbamoylamino)pentanoic acid Suppliers
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View Lastest Price from (2S)-2-[(2S)-2-{[(tert-butoxy)carbonyl]amino}-3-methylbutanamido]-5-(carbamoylamino)pentanoic acid manufacturers
- Product
- Boc-Val-Cit-OH 870487-08-4
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1000kg
- Release date
- 2025-05-08
- Product
- Boc-Val-Cit 870487-08-4
- Price
- US $0.00/g
- Min. Order
- 25g
- Purity
- >95.00%
- Supply Ability
- 25g
- Release date
- 2024-03-29