(2S)-2-[(2S)-2-{[(tert-butoxy)carbonyl]amino}-3-methylbutanamido]-5-(carbamoylamino)pentanoic acid

Product Name: (2S)-2-[(2S)-2-{[(tert-butoxy)carbonyl]amino}-3-methylbutanamido]-5-(carbamoylamino)pentanoic acid
CAS No.: 870487-08-4
Chemical Name: (2S)-2-[(2S)-2-{[(tert-butoxy)carbonyl]amino}-3-methylbutanamido]-5-(carbamoylamino)pentanoic acid
Synonyms: Boc-Val-Cit;Boc-Val-Cit-OH;Boc-L-Val-Cit-OH;Boc-L-valyl-L-citrulline;N-Boc-L-valyl-N5-(aminocarbonyl)-L-ornithine;L-Ornithine, N-[(1,1-dimethylethoxy)carbonyl]-L-valyl-N5-(aminocarbonyl)-;(R)-2-((R)-2-((tert-butoxycarbonyl)amino)-3-methylbutanamido)-5-ureidopentanoic acid;ADC Linkers,Inhibitor,Boc Val Cit OH,BocValCitOH,Antibody-drug conjugates linkers,inhibit;(2S)-2-[[(2S)-2-(tert-butoxycarbonylamino)-3-methyl-butanoyl]amino]-5-ureido-pentanoic acid;(2S)-2-[(2S)-2-{[(tert-butoxy)carbonyl]amino}-3-methylbutanamido]-5-(carbamoylamino)pentanoic acid
CBNumber: CB83373136
Molecular Formula: C16H30N4O6
Formula Weight: 374.43
MOL File: 870487-08-4.mol

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(2S)-2-[(2S)-2-{[(tert-butoxy)carbonyl]amino}-3-methylbutanamido]-5-(carbamoylamino)pentanoic acid Property

Boiling point:: 624.8±55.0 °C(Predicted)
Density: 1.183±0.06 g/cm3(Predicted)
storage temp.: Storage temp. 2-8°C
solubility: Soluble in DMSO
pka: 3.44±0.10(Predicted)
form: Solid
color: White to off-white
InChIKey: ZZLNUAVYYRBTOZ-QWRGUYRKSA-N
SMILES: C(O)(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](C(C)C)NC(OC(C)(C)C)=O

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0096160
Product name: Boc-Val-Cit-OH
Purity: ≥98.0%
Packaging: 100mg
Price: $110
Updated: 2021/12/16

ChemScene

Product number: CS-0096160
Product name: Boc-Val-Cit-OH
Purity: ≥98.0%
Packaging: 250mg
Price: $200
Updated: 2021/12/16

BroadPharm

Product number: BP-24173
Product name: Boc-Val-Cit
Purity: 95%
Packaging: 1g
Price: $240
Updated: 2021/12/16

ChemScene

Product number: CS-0096160
Product name: Boc-Val-Cit-OH
Purity: ≥98.0%
Packaging: 1g
Price: $399
Updated: 2021/12/16

ChemPep

Product number: 181174
Product name: Boc-Val-Cit-OH
Packaging: 5g
Price: $400
Updated: 2021/12/16

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(2S)-2-[(2S)-2-{[(tert-butoxy)carbonyl]amino}-3-methylbutanamido]-5-(carbamoylamino)pentanoic acid Chemical Properties,Usage,Production

Description

Boc-Val-Cit is a cleavable ADC linker. The Val-Cit will specifically be cleaved by Cathepsin B. Boc group can be removed under acidic condition.

Uses

Boc-Val-Cit-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC 50

Protease Cleavable Linker; Cleavable Linker

References

[1] Kevin HAMBLETT, et al. Anti-her2 biparatopic antibody-drug conjugates and methods of use. WO2019173911A1.

(2S)-2-[(2S)-2-{[(tert-butoxy)carbonyl]amino}-3-methylbutanamido]-5-(carbamoylamino)pentanoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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(2S)-2-[(2S)-2-{[(tert-butoxy)carbonyl]amino}-3-methylbutanamido]-5-(carbamoylamino)pentanoic acid Suppliers

China 92 United States 6 Global 98

Kanghua (Shanghai) New Drug Development Co., Ltd.

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YangZhou Ruihong Biotech Co., Ltd.

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Sichuan Tongsheng Amino acids Co.,Ltd.

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Country: China
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Shanghai Haozhixiang Biotechnology Co., Ltd

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View Lastest Price from (2S)-2-[(2S)-2-{[(tert-butoxy)carbonyl]amino}-3-methylbutanamido]-5-(carbamoylamino)pentanoic acid manufacturers

Shanghai Joiny Pharmaceutical Co.,LTD

Product: Boc-Val-Cit-OH 870487-08-4
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000kg
Release date: 2025-05-08

Xian confluore Biological Technology Co., Ltd.

Product: Boc-Val-Cit 870487-08-4
Price: US $0.00/g
Min. Order: 25g
Purity: >95.00%
Supply Ability: 25g
Release date: 2024-03-29

870487-08-4, (2S)-2-[(2S)-2-{[(tert-butoxy)carbonyl]amino}-3-methylbutanamido]-5-(carbamoylamino)pentanoic acidRelated Search:

(S)-2-((S)-2-(tert-butoxycarbonylaMino)-3-MethylbutanaMido)propanoic acid

(2S)-2-[(2S)-2-{[(tert-butoxy)carbonyl]amino}-3-methylbutanamido]-5-(carbamoylamino)pentanoic acid

Boc-Val-Cit-OH

Boc-Val-Cit

L-Ornithine, N-[(1,1-dimethylethoxy)carbonyl]-L-valyl-N5-(aminocarbonyl)-

(R)-2-((R)-2-((tert-butoxycarbonyl)amino)-3-methylbutanamido)-5-ureidopentanoic acid

Boc-L-valyl-L-citrulline

ADC Linkers,Inhibitor,Boc Val Cit OH,BocValCitOH,Antibody-drug conjugates linkers,inhibit

N-Boc-L-valyl-N5-(aminocarbonyl)-L-ornithine

Boc-L-Val-Cit-OH

(2S)-2-[[(2S)-2-(tert-butoxycarbonylamino)-3-methyl-butanoyl]amino]-5-ureido-pentanoic acid

870487-08-4

Linker

ADC LINKER