3,4,5-Trihydroxybenzaldehyde
- Product Name
- 3,4,5-Trihydroxybenzaldehyde
- CAS No.
- 13677-79-7
- Chemical Name
- 3,4,5-Trihydroxybenzaldehyde
- Synonyms
- GALLALDEHYDE;Gallic aldehyde;3,4,5-Trihydroxybenz;Benserazide Impurity 16;3,4,5-TRIHYDROXYBENZALDHYDE;Pyrogallol-5-carboxaldehyde;3,4,5-TRIHYDROXYBENZALDEHYDE;Gallic aldehyde, 10 mM in DMSO;Benzaldehyde, 3,4,5-trihydroxy-;3,4,5-TRIHYDROXYBNEZALDEHYDE MONOHYDRATE
- CBNumber
- CB8340207
- Molecular Formula
- C7H6O4
- Formula Weight
- 154.12
- MOL File
- 13677-79-7.mol
3,4,5-Trihydroxybenzaldehyde Property
- Melting point:
- 211-213°C
- Boiling point:
- 237.46°C (rough estimate)
- Density
- 1.3725 (rough estimate)
- refractive index
- 1.6400 (estimate)
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- Soluble in DMSO and Methanol.
- pka
- 7.46±0.23(Predicted)
- form
- Solid
- color
- White to Pale Yellow
- Sensitive
- Air Sensitive
- BRN
- 2091654
- InChI
- InChI=1S/C7H6O4/c8-3-4-1-5(9)7(11)6(10)2-4/h1-3,9-11H
- InChIKey
- RGZHEOWNTDJLAQ-UHFFFAOYSA-N
- SMILES
- C(=O)C1=CC(O)=C(O)C(O)=C1
- CAS DataBase Reference
- 13677-79-7(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-36/37/39-37
- HS Code
- 29130000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- T2650
- Product name
- 3,4,5-Trihydroxybenzaldehyde
- Packaging
- 1G
- Price
- $140
- Updated
- 2025/07/31
- Product number
- T2650
- Product name
- 3,4,5-Trihydroxybenzaldehyde
- Packaging
- 5G
- Price
- $560
- Updated
- 2025/07/31
- Product number
- T795015
- Product name
- 3,4,5-Trihydroxybenzaldehyde
- Packaging
- 2.5g
- Price
- $180
- Updated
- 2021/12/16
- Product number
- 022355
- Product name
- 3,4,5-Trihydroxybenzaldehyde
- Packaging
- 100mg
- Price
- $446
- Updated
- 2021/12/16
- Product number
- T795015
- Product name
- 3,4,5-Trihydroxybenzaldehyde
- Packaging
- 10g
- Price
- $575
- Updated
- 2021/12/16
3,4,5-Trihydroxybenzaldehyde Chemical Properties,Usage,Production
Chemical Properties
Tan Solid
Uses
3,4,5-trihydroxybenzaldehyde from Geum japonicum has dual inhibitory effect on matrix metalloproteinase 9; inhibition of gelatinoytic activity as well as MMP-9 expression in TNF-α induced HASMC.
Uses
THBA
Synthesis
134-96-3
13677-79-7
The general procedure for the synthesis of 3,4,5-trihydroxybenzaldehyde from butyraldehyde was as follows: 2.0 g of butyraldehyde was accurately weighed into a 250 ml two-necked flask, and about 100 ml of 1,2-dichloroethane was added as a solvent, and stirred thoroughly until dissolved. After cooling the reaction system to 0°C, 7.3 g of anhydrous aluminum trichloride was slowly added and the reaction was stirred for 30 minutes at this temperature. Subsequently, 8.7 g of pyridine was added dropwise through a constant pressure dropping funnel over a period of 20 min, and the reaction mixture was heated to 90 °C and refluxed for 4 h after completion of the dropwise addition. Upon completion of the reaction, the system was cooled to 0 °C and neutralized to pH neutral with a 3 mol/L hydrochloric acid solution. Extraction was carried out with about 250 mL of ethyl acetate and the extract was washed 5 times with ice water to remove impurities. The organic layers were combined, dried by adding anhydrous sodium sulfate, filtered and distilled under reduced pressure to remove the solvent to give a brown solid crude product. The crude product was purified by 200-300 mesh silica gel column chromatography to give 0.83 g of 3,4,5-trihydroxybenzaldehyde in 49% yield. For further purification, the resulting product was recrystallized from water to give an acicular light white solid.
References
[1] Biochemical Pharmacology, 2010, vol. 79, # 11, p. 1658 - 1666
[2] Biochemical Pharmacology, 2010, vol. 79, # 11, p. 1658 - 1666
[3] Patent: CN106188113, 2016, A. Location in patent: Paragraph 0015
[4] Natural Product Research, 2011, vol. 25, # 3, p. 203 - 221
3,4,5-Trihydroxybenzaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3,4,5-Trihydroxybenzaldehyde manufacturers
- Product
- 3,4,5-Trihydroxybenzaldehyde 13677-79-7
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-26
- Product
- 3,4,5-Trihydroxybenzaldehyde 13677-79-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2019-05-24