3,4,5-Trihydroxybenzaldehyde

Product Name: 3,4,5-Trihydroxybenzaldehyde
CAS No.: 13677-79-7
Chemical Name: 3,4,5-Trihydroxybenzaldehyde
Synonyms: GALLALDEHYDE;Gallic aldehyde;3,4,5-Trihydroxybenz;Benserazide Impurity 16;3,4,5-TRIHYDROXYBENZALDHYDE;Pyrogallol-5-carboxaldehyde;3,4,5-TRIHYDROXYBENZALDEHYDE;Gallic aldehyde, 10 mM in DMSO;Benzaldehyde, 3,4,5-trihydroxy-;3,4,5-TRIHYDROXYBNEZALDEHYDE MONOHYDRATE
CBNumber: CB8340207
Molecular Formula: C7H6O4
Formula Weight: 154.12
MOL File: 13677-79-7.mol

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3,4,5-Trihydroxybenzaldehyde Property

Melting point:: 211-213°C
Boiling point:: 237.46°C (rough estimate)
Density: 1.3725 (rough estimate)
refractive index: 1.6400 (estimate)
storage temp.: Inert atmosphere,2-8°C
solubility: Soluble in DMSO and Methanol.
pka: 7.46±0.23(Predicted)
form: Solid
color: White to Pale Yellow
Sensitive: Air Sensitive
BRN: 2091654
InChI: InChI=1S/C7H6O4/c8-3-4-1-5(9)7(11)6(10)2-4/h1-3,9-11H
InChIKey: RGZHEOWNTDJLAQ-UHFFFAOYSA-N
SMILES: C(=O)C1=CC(O)=C(O)C(O)=C1
CAS DataBase Reference: 13677-79-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-36/37/39-37
HS Code: 29130000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: T2650
Product name: 3,4,5-Trihydroxybenzaldehyde
Packaging: 1G
Price: $140
Updated: 2025/07/31

TCI Chemical

Product number: T2650
Product name: 3,4,5-Trihydroxybenzaldehyde
Packaging: 5G
Price: $560
Updated: 2025/07/31

TRC

Product number: T795015
Product name: 3,4,5-Trihydroxybenzaldehyde
Packaging: 2.5g
Price: $180
Updated: 2021/12/16

Usbiological

Product number: 022355
Product name: 3,4,5-Trihydroxybenzaldehyde
Packaging: 100mg
Price: $446
Updated: 2021/12/16

TRC

Product number: T795015
Product name: 3,4,5-Trihydroxybenzaldehyde
Packaging: 10g
Price: $575
Updated: 2021/12/16

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3,4,5-Trihydroxybenzaldehyde Chemical Properties,Usage,Production

Chemical Properties

Tan Solid

Uses

3,4,5-trihydroxybenzaldehyde from Geum japonicum has dual inhibitory effect on matrix metalloproteinase 9; inhibition of gelatinoytic activity as well as MMP-9 expression in TNF-α induced HASMC.

Uses

THBA

Synthesis

134-96-3

13677-79-7

The general procedure for the synthesis of 3,4,5-trihydroxybenzaldehyde from butyraldehyde was as follows: 2.0 g of butyraldehyde was accurately weighed into a 250 ml two-necked flask, and about 100 ml of 1,2-dichloroethane was added as a solvent, and stirred thoroughly until dissolved. After cooling the reaction system to 0°C, 7.3 g of anhydrous aluminum trichloride was slowly added and the reaction was stirred for 30 minutes at this temperature. Subsequently, 8.7 g of pyridine was added dropwise through a constant pressure dropping funnel over a period of 20 min, and the reaction mixture was heated to 90 °C and refluxed for 4 h after completion of the dropwise addition. Upon completion of the reaction, the system was cooled to 0 °C and neutralized to pH neutral with a 3 mol/L hydrochloric acid solution. Extraction was carried out with about 250 mL of ethyl acetate and the extract was washed 5 times with ice water to remove impurities. The organic layers were combined, dried by adding anhydrous sodium sulfate, filtered and distilled under reduced pressure to remove the solvent to give a brown solid crude product. The crude product was purified by 200-300 mesh silica gel column chromatography to give 0.83 g of 3,4,5-trihydroxybenzaldehyde in 49% yield. For further purification, the resulting product was recrystallized from water to give an acicular light white solid.

References

[1] Biochemical Pharmacology, 2010, vol. 79, # 11, p. 1658 - 1666
[2] Biochemical Pharmacology, 2010, vol. 79, # 11, p. 1658 - 1666
[3] Patent: CN106188113, 2016, A. Location in patent: Paragraph 0015
[4] Natural Product Research, 2011, vol. 25, # 3, p. 203 - 221

3,4,5-Trihydroxybenzaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

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3,4,5-Trihydroxybenzaldehyde Suppliers

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View Lastest Price from 3,4,5-Trihydroxybenzaldehyde manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: 3,4,5-Trihydroxybenzaldehyde 13677-79-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-26

Career Henan Chemical Co

Product: 3,4,5-Trihydroxybenzaldehyde 13677-79-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2019-05-24

13677-79-7, 3,4,5-TrihydroxybenzaldehydeRelated Search:

3,4,5-TRIETHOXYBENZOIC ACID 3,4,5-Trimethoxybenzaldehyde Methyl 2-amino-3,4,5-trimethoxybenzoate Dodecyl gallate Syringaldehyde Reserpine 3',4',5'-TRIMETHOXYACETOPHENONE 3,4,5-Trihydroxybenzaldehyde 3-Hydroxy-4,5-dimethoxybenzoic acid Gallic acid monohydrate Methyl 3,4,5-trimethoxybenzoate 3,4,5-TRIHYDROXYBENZAMIDE Methyl 2-nitro-3,4,5-trimethoxybenzoate 3,4,5-Trimethoxy benzoic acid Propyl gallate Octyl gallate Acetosyringone ISOPROPYLGALLATE

3,4,5-Trihydroxybenzaldehyde hydrate, 97%, dry wt. basis

GALLALDEHYDE

3,4,5-TRIHYDROXYBENZALDEHYDE HYDRATE 97%

3,4,5-TRIHYDROXYBNEZALDEHYDE MONOHYDRATE

3,4,5-TRIHYDROXYBENZALDHYDE

3,4,5-TRIHYDROXYBENZALDEHYDE

3,4,5-Trihydroxybenz

Pyrogallol-5-carboxaldehyde

Gallic aldehyde

Benzaldehyde, 3,4,5-trihydroxy-

3,4,5-Trihydroxybenzaldehyde ISO 9001：2015 REACH

Benserazide Impurity 16

Gallic aldehyde, 10 mM in DMSO

13677-79-7

Aromatic Aldehydes & Derivatives (substituted)

Aromatics

Inhibitors