ChemicalBook > CAS DataBase List > TETRAGASTRIN

TETRAGASTRIN

Product Name: TETRAGASTRIN
CAS No.: 1947-37-1
Chemical Name: TETRAGASTRIN
Synonyms: TETRAGASTRIN;CCK-4 Acetate;Trp-Met-Asp-Phe amide;Cholecystokinin(36-39);Tetragastrin hydrochloride;CCK-4, CCKB receptor agonist;H-Trp-Met-Asp-Phe-NH2 acetate;Cholecystokinin, CCK Tetrapeptide;4-7-Cholecystokinin-7 (swine) (9CI);CCK-4 Acetate, Gastrin Tetrapeptide
CBNumber: CB8341406
Molecular Formula: C29H36N6O6S
Formula Weight: 596.7
MOL File: 1947-37-1.mol

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TETRAGASTRIN Property

Melting point:: 185-195 °C
Boiling point:: 1070.0±65.0 °C(Predicted)
Density: 1.348±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMF: 20mg/mL, clear, colorless to yellow
form: Solid
pka: 4.19±0.10(Predicted)
color: White to off-white

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Safety

WGK Germany: 3
Toxicity: dog,LD,intravenous,> 100mg/kg (100mg/kg),GASTROINTESTINAL: NAUSEA OR VOMITINGGASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"BEHAVIORAL: EXCITEMENT,Oyo Yakuri. Pharmacometrics. Vol. 3, Pg. 121, 1969.

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T6515
Product name: Cholecystokinin Fragment 30-33 Amide
Purity: ≥95% (HPLC)
Packaging: 100mg
Price: $293
Updated: 2025/07/31

American Custom Chemicals Corporation

Product number: PEP0011758
Product name: TETRAGASTRIN
Purity: 95.00%
Packaging: 5MG
Price: $496.32
Updated: 2021/12/16

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TETRAGASTRIN Chemical Properties,Usage,Production

Uses

Cholecystokinin Fragment 30-33 Amide can be used for inactivating the CCK8 antiserum. The product can also be used as an antigen utilized in absorption control for testing the specificity of antisera.

Definition

ChEBI: Tetragastrin is a tetrapeptide composed of L-tryptophan, L-methione, L-aspartic acid and L-phenylalaninamide residues joined in sequence. It has a role as an anxiogenic and a human metabolite. It is a tetrapeptide and a peptidyl amide.

Hazard

Moderately toxic by ingestion

Biochem/physiol Actions

Cholecystokinin Fragment 30-33 Amide also referred to as CCK-4 or Trp-Met-Asp-Phe amide is a peptide fragment derived from peptide hormone cholecystokinin. CCK-4 is a panicogenic agent that induces panic attacks in humans. This property of the compound can be used in scientific research for testing the new anxiolytic drugs.

in vivo

In inbred Wistar rats treated with N-methyl-N'-nitro-N-nitrosoguanidine, Tetragastrin (s.c.; 1 mg/kg; every other day) treatment significantly reduces the incidence and the number of adenocarcinomas, and has a significantly lower labelling index of the antral mucosa^[1].
Tetragastrin has potential for enhancing gastric mucosal protection associated with mucus secretion and/or mucus synthesis on the surface mucosa of rat gastric mucosa. A significant increase in the mucin content was noted in the mucus gel and surface mucosal layer. An increase in mucin in the mucus gel and surface mucosa would thus appear due to the administration of Tetragastrin^[3].

Animal Model:	Seven-week-old male Wistar rats, each weighing approximately 160 g^[3]
Dosage:	12, 120, or 400 μg/kg
Administration:	Administered subcutaneously (s.c.); followed by 50% ethanol-induced gastric injury
Result:	Caused a significant increase in mucin content in the corpus mucosa and prevented 50% ethanol-induced gastric mucosal damage in a dose-dependent manner.

TETRAGASTRIN Preparation Products And Raw materials

Raw materials

Preparation Products

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1947-37-1, TETRAGASTRINRelated Search:

Tetrapeptide-30 Tetrapeptide-16 Tetrapeptide-14 Tetrapeptide-21 PENTAGASTRIN Cholecystokinin Carbobenzoxy-D,L-tryptophanamide Z-TRP-NH2 Z-TRP-NHME TETRAGASTRIN

(3S)-3-[[(1S)-1-carbamoyl-2-phenyl-ethyl]carbamoyl]-3-[[(2S)-2-[[(2S)-3-(1H-indol-3-yl)-2-phenylmethoxycarbonylamino-propanoyl]amino]-4-methylsulfanyl-butanoyl]amino]propanoic acid

4-7-Cholecystokinin-7 (swine) (9CI)

Alaninamide, L-tryptophyl-L-methionyl-L-aspartylphenyl- (7CI)

Alaninamide, L-tryptophyl-L-methionyl-L-aspartylphenyl-, L- (8CI)

Cholecystokinin C-terminal tetrapeptide

Cholecystokinin(36-39)

L-Phenylalaninamide, L-tryptophyl-L-methionyl-L-a-aspartyl-

Cholecystokinin fragment 30-33 amide

Cholecystokinin Tetrapeptide, Cholecystokinin Octapeptide (5-8), CCK-4, Gastrin (14-17) (huMan)

H-Trp-Met-Asp-Phe-NH2 acetate

Tetragastrin hydrochloride

Trp-Met-Asp-Phe amide

CCK-4 Acetate

Cholecystokinin, CCK Tetrapeptide

TETRAGASTRIN

CCK-4 Acetate, Gastrin Tetrapeptide

L-Phenylalaninamide, L-tryptophyl-L-methionyl-L-α-aspartyl-

Cholecystokinin Fragment 30-33 Amide >=95% (HPLC)

Gastrin Tetrapeptide H-Trp-Met-Asp-Phe-NH2

CCK-4, CCKB receptor agonist

1947-37-1