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PENTAGASTRIN

Product Name
PENTAGASTRIN
CAS No.
5534-95-2
Chemical Name
PENTAGASTRIN
Synonyms
GRP;ay6608;ici50123;petavlon;peptavlon;petogasrin;lanineamide;PENTAGASTRIN;Pehtagastrin;gastrodiagnost
CBNumber
CB4412263
Molecular Formula
C37H49N7O9S
Formula Weight
767.9
MOL File
5534-95-2.mol
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PENTAGASTRIN Property

Melting point:
229-230° (dec)
alpha 
D22 -28.8 ±0.5° (DMF)
Boiling point:
1196.6±65.0 °C(Predicted)
Density 
1.303±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Practically insoluble in water; soluble in 5M ammonia and in dimethylformamide; slightly soluble in ethanol (96%).
pka
4.19±0.10(Predicted)
form 
powder
color 
White to off-white
Sequence
N-t-Boc-β-Ala-Trp-Met-Asp-Phe-NH2
InChIKey
NEYNJQRKHLUJRU-DZUOILHNSA-N
SMILES
C(C1=CNC2C=CC=CC1=2)[C@H](NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N)CC1C=CC=CC=1 |&1:10,27,35,43,r|
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Safety

Hazard Codes 
T
Risk Statements 
61-36/38-20/21
Safety Statements 
53-45-36/37/39-22
WGK Germany 
1
RTECS 
AY2970000
Hazardous Substances Data
5534-95-2(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
BP278
Product name
Pentagastrin
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
5MG
Price
$266
Updated
2024/03/01
Sigma-Aldrich
Product number
B1636
Product name
Pentagastrin
Purity
≥95% (HPLC), powder
Packaging
25mg
Price
$266
Updated
2024/03/01
Sigma-Aldrich
Product number
B1636
Product name
Pentagastrin
Purity
≥95% (HPLC), powder
Packaging
100mg
Price
$864
Updated
2024/03/01
Cayman Chemical
Product number
28546
Product name
Pentagastrin
Packaging
10mg
Price
$73
Updated
2024/03/01
Cayman Chemical
Product number
28546
Product name
Pentagastrin
Packaging
100mg
Price
$431
Updated
2024/03/01
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PENTAGASTRIN Chemical Properties,Usage,Production

Description

Pentagastrin is a synthetic polypeptide and cholecystokinin-2 (CCK2) receptor agonist. It binds selectively to CCK2 receptors in guinea pig brain over CCK1 receptors in rat pancreas (IC50s = 11 and 1,100 nM, respectively). Pentagastrin increases calcium influx and polyphosphoinositide turnover in rat GH3 pituitary cells (EC50s = 23 and 3.9 nM, respectively). It also increases histidine decarboxylase activity in mucous- and endocrine cell-enriched isolated rabbit fundic mucosal cells (EC50 = 2.9 nM). Pentagastrin induces contraction of isolated pig ileum smooth muscle cells in vitro (EC50 = 30 pM). It increases gastric acid and pepsin secretion in conscious cats in vivo (ED50s = 1.29 and 57.3 nmol/kg2 per hour, respectively). Formulations containing pentagastrin have previously been used as a diagnostic aid to evaluate gastric acid secretory function.

Chemical Properties

A white or almost white powder.

Originator

Peptavlon,I.C.I. ,UK,1967

Uses

Pentagastrin is a synthetic polypeptide that has effects like gastrin when given parenterally. It stimulates the secretion of gastric acid, pepsin, and intrinsic factor, and has been used as a diagnostic aid as the pentagastrin-stimulated calcitonin test.

Uses

anesthetic (local)

Uses

diagnostic agent for gastric secretion disorders

Definition

ChEBI: Pentagastrin is an organic molecular entity.

Manufacturing Process

A solution of 3.55 parts of L-tryptophanyl-L-methionyl-L-aspartyl-Lphenylalanine amide trifluoroacetate in 30 parts of dimethylformamide is cooled to 0°C, and 1.01 parts of triethylamine are added. The mixture is stirred while 1.84 parts of N-tert-butyloxycarbonyl-β-alanine 2,4,5trichlorophenyI ester are added at 0°C. The reaction mixture is kept at 0°C for 48 hours and then at 20°-23°C for 24 hours. The mixture is added to a mixture of 100 parts of ice-water, 0.37 part of concentrated hydrochloric acid (SG 1.18), 1.2 parts of acetic acid and 20 parts of ethyl acetate. The mixture is stirred for 15 minutes at 0°-10°C and is then filtered. The solid residue is washed with water and then with ethyl acetate, and is dried at 40°-50°C under reduced pressure. There is thus obtained N-tert-butyloxycarbonyl-βalanyl-L-tryptophanyl-L-methionyl-L-aspartyl-L-phenylalanine amide, MP 213°C with de composition.

brand name

Peptavlon (Wyeth).

Therapeutic Function

Gastrosecretory hormone

General Description

Pentagastrin (Peptavlon), a physiologicalgastric acid secretagogue, is the synthetic pentapeptide derivative:N-t-butyloxycarbonyl-β-alanyl-L-tryptophyl-L-methionyl-L-aspartyl-L-phenylalanyl amide. It contains theCOOH-terminal tetrapeptide amide (H·Try·Met· Asp·Phe·NH2), which is considered to be the active center ofthe natural gastrins. Accordingly, pentagastrin appears tohave the physiological and pharmacological properties ofthe gastrins, including stimulation of gastric secretion,pepsin secretion, gastric motility, pancreatic secretion ofwater and bicarbonate, pancreatic enzyme secretion, biliaryflow and bicarbonate output, intrinsic factor secretion, andcontraction of the gallbladder.
Pentagastrin is indicated as a diagnostic agent to evaluategastric acid secretory function, and it is useful in testing foranacidity in patients with suspected pernicious anemia, atrophicgastritis or gastric carcinoma, hypersecretion in suspectedduodenal ulcer or postoperative stomal ulcers, andZollinger-Ellison tumor.

Biochem/physiol Actions

CCKB agonist that stimulates gastric acid secretion; anxiogenic.Pentagastrin is an agonist of the cholecystokinin-2 (CCK2) receptor. It helps to increase the excitability of neurons in the basolateral amygdala through the activation of a non-specific cation channel.

PENTAGASTRIN Preparation Products And Raw materials

Raw materials

β-Alanine N-[(tert-Butoxy)carbonyl]-D-tryptophan Protective agent Propionamide L-ASPARTIC ACID

Preparation Products

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PENTAGASTRIN Suppliers

China 145 Europe 2 France 1 Germany 2 Switzerland 1 United States 28 Global 179
Hangzhou Peptidego Biotech Co.,Ltd.
Tel
0571-87213919
Fax
0571-87213919
Email
Eric@peptidego.com
Country
China
ProdList
6968
Advantage
58
Phygene
Tel
18059081430
Email
2070812664@qq.com
Country
China
ProdList
1232
Advantage
58
GL Biochem (Shanghai) Ltd
Tel
21-61263452 13641803416
Fax
86-21-61263399
Email
ymbetter@glbiochem.com
Country
China
ProdList
9981
Advantage
64
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
Advantage
70
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Cellmano Biotech Limited
Tel
0551-65326643 18156095617
Fax
0551-65326641
Email
info@cellmano.com
Country
China
ProdList
1011
Advantage
55
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
meilunui@163.com
Country
China
ProdList
4727
Advantage
58
ShangHai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847 13636370518
Fax
021-55068248
Email
shyysw007@163.com
Country
China
ProdList
4940
Advantage
60
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-400-6206333 18521732826
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
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View Lastest Price from PENTAGASTRIN manufacturers

Watson Biotechnology Co.,Ltd
Product
Pehtagastrin 5534-95-2
Price
US $0.00-0.00/G
Min. Order
1G
Purity
98%
Supply Ability
1000G
Release date
2024-08-15
Shandong Huizhihan Supply Chain Co., Ltd
Product
Pentagastrin 5534-95-2
Price
US $0.00-0.00/BOX
Min. Order
1BOX
Purity
99.99%
Supply Ability
1000
Release date
2024-11-04
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Pentagastrin 5534-95-2
Price
US $0.00/g
Min. Order
1g
Purity
98%
Supply Ability
20kg/month
Release date
2021-07-20

5534-95-2, PENTAGASTRINRelated Search:

Terlipressin acetate Lypressin Ornipressin ARGIPRESSIN ACETATE Sucralfate PENTAGASTRIN tert-Butyl 3-(methylamino)propylcarbamate N-Boc-1,3-propanediamine MET-BETA-ALA GASTRIN (14-17) (HUMAN) Carbamic acid, [3-(propylamino)propyl]-, 1,1-dimethylethyl ester (9CI) PENTAGASTRIN BP STANDARD(CRM STANDARD) rat gastrin C-terminal pentagastrin (ortho-nitrophenyl)sulfenyl pentagastrin cholecystokinin 5-pentagastrin PENTAGASTRIN BP(CRM STANDARD) Pentagastrin, blocked PENTAGASTRIN, [3H]

  • T-BOC-BETA-ALA-TRP-MET-ASP-PHE-NH2
  • aspartyl]-l-phenylalaninamide
  • ay6608
  • boc-beta-ala-try-met-asp-phe(nh2)
  • gastrodiagnost
  • ici50123
  • lanineamide
  • l-methionyl-l-alpha-aspartyl-
  • l-n-tert-butyleste
  • n-((1,1-dimethylethoxy)carbonyl)-beta-alanyl-l-tryptophyl-l-phenylalaninamid
  • Acetyl-L-glutamic acid &gamma
  • Z-N-methyl-L-glutamic acid &gamma
  • N-(Benzyloxycarbonyl)-L-glutamic Acid &alpha
  • Fmoc-L-alpha-aminoadipic acid &delta
  • Fmoc-N-methyl-L-glutamic acid &gamma
  • Methotrexate &alpha
  • petogasrin
  • -tert-butylester
  • ylpropionamido]-4-(methylthio)butyramido]succinamicacidn-tert-butylester
  • n-t-boc-β-ala-trp-met-asp-phe amide
  • N-T-boc-B-ala-trp-met-asp-phe amide
  • PENTAGASTRIN (ICI 50123) SYNTHETIC >99%
  • BOC-β-Ala-Trp-Met-Asp-Phe-NH2
  • N-(1,1-Dimethylethoxy)carbonyl-βAla-L-Trp-L-Met-L-Asp-L-Phe-NH2
  • N-Boc-βAla-L-Trp-L-Met-L-Asp-L-Phe-NH2
  • AY 6608, ICI 50123, NSC 367746, Boc-(b-Ala13)-Gastrin (13-17), Boc-b-Ala-CCK-4
  • Boc-b-Ala-Trp-Met-Asp-Phe-NH2
  • 3-7-Cholecystokinin-7(swine), 3-[N-[(1,1-dimethylethoxy)carbonyl]-b-alanine]- (9CI)
  • L-Glutamic Acid &alpha
  • DL-Glutamic acid &gamma
  • N-tert-Butyloxycarbonyl-L-aspartic Acid &beta
  • Pentagastrin, ≥95%(HPLC)
  • n-(alpha-carbamoylphenethyl)-3-[2-[2-[3-(carboxyamino)propionamido]-3-indol-3-
  • n-[n-[n-[n-(n-tert-butoxycarbonyl-beta-alanyl)-l-tryptophanyl]-l-methionyl]-l-
  • n-carboxy-beta-alanyl-l-tryptophyl-l-methionyl-l-aspartylphenyl-alaninamid
  • n-carboxy-beta-alanyl-l-tryptophyl-l-methionyl-l-aspartylphenyl-l-alaninamiden
  • n-t-butyloxycarbonyl-beta-alanyl-l-tryptophyl-l-methionyl-l-aspartyl-l-phenyla
  • peptavlon
  • petavlon
  • Boc-(β-Ala13)-Gastrin (13-17)
  • GRP
  • GASTRIN RELEASING PEPTIDE
  • BOC-BETA-ALA-TRP-MET-ASP-PHE-NH2
  • PENTAGASTRIN
  • N-T-BOC-BETA-ALA-TRP-MET-ASP-PHE AMIDE
  • Z-L-beta-Glutamic acid &gamma
  • Fmoc-L-aspartic Acid &beta
  • Pehtagastrin
  • L-Phenylalaninamide, N-[(1,1-dimethylethoxy)carbonyl]-β-alanyl-L-tryptophyl-L-methionyl-L-α-aspartyl-
  • PENTAGASTRIN USP/EP/BP
  • Boc-(β-Ala13)-Gastrin (13-17)
  • (10S,13S,16S)-10-((1H-Indol-3-yl)methyl)-16-(((S)-1-amino-1-oxo-3-phenylpropan-2-yl)carbamoyl)-2,2-dimethyl-13-(2-(methylthio)ethyl)-4,8,11,14-tetraoxo-3-oxa-5,9,12,15-tetraazaoctadecan-18-oic acid
  • 5534-95-2
  • C37H49N7O9S
  • C37H50N7O9S
  • Gastrointestinal Products
  • Cholecystokinins
  • Peptides