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PENTAGASTRIN

Product Name
PENTAGASTRIN
CAS No.
5534-95-2
Chemical Name
PENTAGASTRIN
Synonyms
GRP;ay6608;ici50123;petavlon;peptavlon;petogasrin;lanineamide;PENTAGASTRIN;Pehtagastrin;gastrodiagnost
CBNumber
CB4412263
Molecular Formula
C37H49N7O9S
Formula Weight
767.9
MOL File
5534-95-2.mol
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PENTAGASTRIN Property

Melting point:
229-230° (dec)
alpha 
D22 -28.8 ±0.5° (DMF)
Boiling point:
1196.6±65.0 °C(Predicted)
Density 
1.303±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Practically insoluble in water; soluble in 5M ammonia and in dimethylformamide; slightly soluble in ethanol (96%).
pka
4.19±0.10(Predicted)
form 
powder
InChIKey
NEYNJQRKHLUJRU-DZUOILHNSA-N
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Safety

Hazard Codes 
T
Risk Statements 
61-36/38-20/21
Safety Statements 
53-45-36/37/39-22
WGK Germany 
1
RTECS 
AY2970000
Hazardous Substances Data
5534-95-2(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
B1636
Product name
Pentagastrin
Purity
≥95% (HPLC), powder
Packaging
25mg
Price
$216
Updated
2021/03/22
Sigma-Aldrich
Product number
B1636
Product name
Pentagastrin
Purity
≥95% (HPLC), powder
Packaging
100mg
Price
$702
Updated
2021/03/22
Cayman Chemical
Product number
28546
Product name
Pentagastrin
Packaging
100mg
Price
$354
Updated
2021/03/22
Cayman Chemical
Product number
28546
Product name
Pentagastrin
Packaging
10mg
Price
$59
Updated
2021/03/22
Cayman Chemical
Product number
28546
Product name
Pentagastrin
Packaging
25mg
Price
$118
Updated
2021/03/22
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PENTAGASTRIN Chemical Properties,Usage,Production

Chemical Properties

A white or almost white powder.

Originator

Peptavlon,I.C.I. ,UK,1967

Uses

anesthetic (local)

Uses

diagnostic agent for gastric secretion disorders

Manufacturing Process

A solution of 3.55 parts of L-tryptophanyl-L-methionyl-L-aspartyl-Lphenylalanine amide trifluoroacetate in 30 parts of dimethylformamide is cooled to 0°C, and 1.01 parts of triethylamine are added. The mixture is stirred while 1.84 parts of N-tert-butyloxycarbonyl-β-alanine 2,4,5trichlorophenyI ester are added at 0°C. The reaction mixture is kept at 0°C for 48 hours and then at 20°-23°C for 24 hours. The mixture is added to a mixture of 100 parts of ice-water, 0.37 part of concentrated hydrochloric acid (SG 1.18), 1.2 parts of acetic acid and 20 parts of ethyl acetate. The mixture is stirred for 15 minutes at 0°-10°C and is then filtered. The solid residue is washed with water and then with ethyl acetate, and is dried at 40°-50°C under reduced pressure. There is thus obtained N-tert-butyloxycarbonyl-βalanyl-L-tryptophanyl-L-methionyl-L-aspartyl-L-phenylalanine amide, MP 213°C with de composition.

brand name

Peptavlon (Wyeth).

Therapeutic Function

Gastrosecretory hormone

General Description

Pentagastrin (Peptavlon), a physiologicalgastric acid secretagogue, is the synthetic pentapeptide derivative:N-t-butyloxycarbonyl-β-alanyl-L-tryptophyl-L-methionyl-L-aspartyl-L-phenylalanyl amide. It contains theCOOH-terminal tetrapeptide amide (H·Try·Met· Asp·Phe·NH2), which is considered to be the active center ofthe natural gastrins. Accordingly, pentagastrin appears tohave the physiological and pharmacological properties ofthe gastrins, including stimulation of gastric secretion,pepsin secretion, gastric motility, pancreatic secretion ofwater and bicarbonate, pancreatic enzyme secretion, biliaryflow and bicarbonate output, intrinsic factor secretion, andcontraction of the gallbladder.
Pentagastrin is indicated as a diagnostic agent to evaluategastric acid secretory function, and it is useful in testing foranacidity in patients with suspected pernicious anemia, atrophicgastritis or gastric carcinoma, hypersecretion in suspectedduodenal ulcer or postoperative stomal ulcers, andZollinger-Ellison tumor.

PENTAGASTRIN Preparation Products And Raw materials

Raw materials

Preparation Products

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PENTAGASTRIN Suppliers

Avantpbc Chemical Tech(Shanghai) Co,Ltd.
Tel
17802107445;021-3120-8408
Country
China
ProdList
186
Advantage
55
Hangzhou Peptidego Biotech Co.,Ltd.
Tel
0571-87213919-
Fax
0571-87213919
Email
eric@peptidego.com
Country
China
ProdList
4679
Advantage
58
GL Biochem (Shanghai) Ltd
Tel
21-61263452- ;21-61263452-
Fax
86-21-61263399
Email
ymbetter@glbiochem.com;ymbetter@glbiochem.com
Country
China
ProdList
9940
Advantage
64
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
1938
Advantage
70
Nanjing Chemlin Chemical Co., Ltd
Tel
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
20001
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202- ; ;
Email
jerry.ma@hanhonggroup.com;jerry.ma@hanhonggroup.com;jerry.ma@hanhonggroup.com
Country
China
ProdList
43255
Advantage
64
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32358
Advantage
50
Cellmano Biotech Limited
Tel
0551-65326643-
Fax
0551-65326641
Email
info@cellmano.com
Country
China
ProdList
1011
Advantage
55
BOC Sciences
Tel
Email
info@bocsci.com
Country
United States
ProdList
9942
Advantage
65
Dalian Meilun Biotech Co., Ltd.
Tel
0411-66864596- ;0411-66864952-
Email
sales@meilune.com;sales@meilune.com
Country
China
ProdList
3576
Advantage
58
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View Lastest Price from PENTAGASTRIN manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Pentagastrin 5534-95-2
Price
US $0.00/g
Min. Order
1g
Purity
98%
Supply Ability
20kg/month
Release date
2021-07-20
Dideu Industries Group Limited
Product
PENTAGASTRIN USP/EP/BP 5534-95-2
Price
US $1.10/g
Min. Order
1g
Purity
0.999
Supply Ability
100 Tons min
Release date
2021-08-12
Zhuozhou Wenxi import and Export Co., Ltd
Product
PENTAGASTRIN 5534-95-2
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

5534-95-2, PENTAGASTRINRelated Search:


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