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PENTAGASTRIN

Product Name
PENTAGASTRIN
CAS No.
5534-95-2
Chemical Name
PENTAGASTRIN
Synonyms
GRP;ay6608;ici50123;petavlon;peptavlon;petogasrin;lanineamide;PENTAGASTRIN;Pehtagastrin;gastrodiagnost
CBNumber
CB4412263
Molecular Formula
C37H49N7O9S
Formula Weight
767.9
MOL File
5534-95-2.mol
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PENTAGASTRIN Property

Melting point:
229-230° (dec)
alpha 
D22 -28.8 ±0.5° (DMF)
Boiling point:
1196.6±65.0 °C(Predicted)
Density 
1.303±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Practically insoluble in water; soluble in 5M ammonia and in dimethylformamide; slightly soluble in ethanol (96%).
pka
4.19±0.10(Predicted)
form 
powder
Sequence
N-t-Boc-β-Ala-Trp-Met-Asp-Phe-NH2
InChIKey
NEYNJQRKHLUJRU-DZUOILHNSA-N
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Safety

Hazard Codes 
T
Risk Statements 
61-36/38-20/21
Safety Statements 
53-45-36/37/39-22
WGK Germany 
1
RTECS 
AY2970000
Hazardous Substances Data
5534-95-2(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
BP278
Product name
Pentagastrin
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
5MG
Price
$266
Updated
2024/03/01
Sigma-Aldrich
Product number
B1636
Product name
Pentagastrin
Purity
≥95% (HPLC), powder
Packaging
25mg
Price
$266
Updated
2024/03/01
Sigma-Aldrich
Product number
B1636
Product name
Pentagastrin
Purity
≥95% (HPLC), powder
Packaging
100mg
Price
$864
Updated
2024/03/01
Cayman Chemical
Product number
28546
Product name
Pentagastrin
Packaging
10mg
Price
$73
Updated
2024/03/01
Cayman Chemical
Product number
28546
Product name
Pentagastrin
Packaging
100mg
Price
$431
Updated
2024/03/01
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PENTAGASTRIN Chemical Properties,Usage,Production

Description

Pentagastrin is a synthetic polypeptide and cholecystokinin-2 (CCK2) receptor agonist. It binds selectively to CCK2 receptors in guinea pig brain over CCK1 receptors in rat pancreas (IC50s = 11 and 1,100 nM, respectively). Pentagastrin increases calcium influx and polyphosphoinositide turnover in rat GH3 pituitary cells (EC50s = 23 and 3.9 nM, respectively). It also increases histidine decarboxylase activity in mucous- and endocrine cell-enriched isolated rabbit fundic mucosal cells (EC50 = 2.9 nM). Pentagastrin induces contraction of isolated pig ileum smooth muscle cells in vitro (EC50 = 30 pM). It increases gastric acid and pepsin secretion in conscious cats in vivo (ED50s = 1.29 and 57.3 nmol/kg2 per hour, respectively). Formulations containing pentagastrin have previously been used as a diagnostic aid to evaluate gastric acid secretory function.

Chemical Properties

A white or almost white powder.

Originator

Peptavlon,I.C.I. ,UK,1967

Uses

Pentagastrin is a synthetic polypeptide that has effects like gastrin when given parenterally. It stimulates the secretion of gastric acid, pepsin, and intrinsic factor, and has been used as a diagnostic aid as the pentagastrin-stimulated calcitonin test.

Uses

anesthetic (local)

Uses

diagnostic agent for gastric secretion disorders

Definition

ChEBI: Pentagastrin is an organic molecular entity.

Manufacturing Process

A solution of 3.55 parts of L-tryptophanyl-L-methionyl-L-aspartyl-Lphenylalanine amide trifluoroacetate in 30 parts of dimethylformamide is cooled to 0°C, and 1.01 parts of triethylamine are added. The mixture is stirred while 1.84 parts of N-tert-butyloxycarbonyl-β-alanine 2,4,5trichlorophenyI ester are added at 0°C. The reaction mixture is kept at 0°C for 48 hours and then at 20°-23°C for 24 hours. The mixture is added to a mixture of 100 parts of ice-water, 0.37 part of concentrated hydrochloric acid (SG 1.18), 1.2 parts of acetic acid and 20 parts of ethyl acetate. The mixture is stirred for 15 minutes at 0°-10°C and is then filtered. The solid residue is washed with water and then with ethyl acetate, and is dried at 40°-50°C under reduced pressure. There is thus obtained N-tert-butyloxycarbonyl-βalanyl-L-tryptophanyl-L-methionyl-L-aspartyl-L-phenylalanine amide, MP 213°C with de composition.

brand name

Peptavlon (Wyeth).

Therapeutic Function

Gastrosecretory hormone

General Description

Pentagastrin (Peptavlon), a physiologicalgastric acid secretagogue, is the synthetic pentapeptide derivative:N-t-butyloxycarbonyl-β-alanyl-L-tryptophyl-L-methionyl-L-aspartyl-L-phenylalanyl amide. It contains theCOOH-terminal tetrapeptide amide (H·Try·Met· Asp·Phe·NH2), which is considered to be the active center ofthe natural gastrins. Accordingly, pentagastrin appears tohave the physiological and pharmacological properties ofthe gastrins, including stimulation of gastric secretion,pepsin secretion, gastric motility, pancreatic secretion ofwater and bicarbonate, pancreatic enzyme secretion, biliaryflow and bicarbonate output, intrinsic factor secretion, andcontraction of the gallbladder.
Pentagastrin is indicated as a diagnostic agent to evaluategastric acid secretory function, and it is useful in testing foranacidity in patients with suspected pernicious anemia, atrophicgastritis or gastric carcinoma, hypersecretion in suspectedduodenal ulcer or postoperative stomal ulcers, andZollinger-Ellison tumor.

Biochem/physiol Actions

CCKB agonist that stimulates gastric acid secretion; anxiogenic.Pentagastrin is an agonist of the cholecystokinin-2 (CCK2) receptor. It helps to increase the excitability of neurons in the basolateral amygdala through the activation of a non-specific cation channel.

PENTAGASTRIN Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from PENTAGASTRIN manufacturers

Zibo Hangyu Biotechnology Development Co., Ltd
Product
Pentagastrin 5534-95-2
Price
US $75.00-750.00/kg
Min. Order
10kg
Purity
0.99
Supply Ability
20tons
Release date
2023-11-27
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Pentagastrin 5534-95-2
Price
US $0.00/g
Min. Order
1g
Purity
98%
Supply Ability
20kg/month
Release date
2021-07-20
Henan Bao Enluo International TradeCo.,LTD
Product
Pentagastrin 5534-95-2
Price
US $45.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20tons
Release date
2023-05-18

5534-95-2, PENTAGASTRINRelated Search:


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  • AY 6608, ICI 50123, NSC 367746, Boc-(b-Ala13)-Gastrin (13-17), Boc-b-Ala-CCK-4
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  • L-Phenylalaninamide, N-[(1,1-dimethylethoxy)carbonyl]-β-alanyl-L-tryptophyl-L-methionyl-L-α-aspartyl-
  • PENTAGASTRIN USP/EP/BP
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  • 5534-95-2
  • C37H49N7O9S
  • C37H50N7O9S
  • Gastrointestinal Products
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  • Peptides
  • Amino Acids and Peptides