8-METHYL-4-QUINAZOLONE

Product Name: 8-METHYL-4-QUINAZOLONE
CAS No.: 19181-54-5
Chemical Name: 8-METHYL-4-QUINAZOLONE
Synonyms: 8-METHYL-4-QUINAZOLONE;8-Methylquinazolin-4-ol;8-Methylquinazolin-4(3H);8-methyl-4-quinazolinone;8-methyl-1H-quinazolin-4-one;8-Methylquinazolin-4(3H)-one;8-METHYL-3H-QUINAZOLIN-4-ONE;8-methylquinazolin-4(1H)-one;8-Methyl-4(3H)-Quinazolinone;8-Methylquinazolin-4(3H)-one98%
CBNumber: CB8347958
Molecular Formula: C9H8N2O
Formula Weight: 160.17
MOL File: 19181-54-5.mol

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8-METHYL-4-QUINAZOLONE Property

storage temp.: Sealed in dry,Room Temperature
form: solid
color: Faint beige

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Safety

Hazard Codes: Xi
Hazard Note: Irritant
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: M219915
Product name: 8-Methylquinazolin-4(3H)-one
Packaging: 50mg
Price: $60
Updated: 2021/12/16

Apolloscientific

Product number: OR8297
Product name: 8-Methylquinazolin-4(3H)-one
Purity: 98%
Packaging: 250mg
Price: $21
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H48-1-J8
Product name: 8-Methylquinazolin-4(3H)-one
Purity: 98%
Packaging: 250mg
Price: $24
Updated: 2021/12/16

ChemScene

Product number: CS-W001049
Product name: 8-methylquinazolin-4-ol
Packaging: 1g
Price: $50
Updated: 2021/12/16

Apolloscientific

Product number: OR8297
Product name: 8-Methylquinazolin-4(3H)-one
Purity: 98%
Packaging: 1g
Price: $53
Updated: 2021/12/16

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8-METHYL-4-QUINAZOLONE Chemical Properties,Usage,Production

Synthesis Reference(s)

Synthetic Communications, 14, p. 1013, 1984 DOI: 10.1080/00397918408059628

Synthesis

4389-45-1

77287-34-4

19181-54-5

Formamide (26 mL, 0.6600 mol) was added to 2-amino-3-methylbenzoic acid (100 g, 0.66 mol) and formamidine acetate (206 g, 1.98 mol) in a 2L round-bottomed flask equipped with a mechanical stirrer. The reaction mixture was heated at 160 °C for 16 h. The reaction process was monitored by LCMS. After completion of the reaction, the mixture was cooled to room temperature and diluted with 2N NaOH solution (300 mL). After stirring for 15 min at room temperature, the reaction mixture was neutralized with 1.5N HCl solution. The precipitated solid product was collected by filtration, washed with ice water and dried under vacuum to afford 8-methyl-4-quinazolone (90 g, 86% yield) as an off-white solid. The structure of the product was confirmed by 1H NMR (DMSO-d6, 400 MHz): δ 12.21 (bs, 1H), 8.10 (s, 1H), 7.95-7.93 (dd, J = 8.8, 7.9 Hz, 1H), 7.65-7.63 (d, J = 7.9 Hz, 1H), 7.39-7.35 (t, J = 15.2 Hz, 1H ), 2.51 (s, 3H).

References

[1] Patent: WO2013/96194, 2013, A1. Location in patent: Page/Page column 28-29
[2] European Journal of Medicinal Chemistry, 2012, vol. 50, p. 264 - 273
[3] Journal of Medicinal Chemistry, 2016, vol. 59, # 6, p. 2794 - 2809
[4] Chemische Berichte, 1905, vol. 38, p. 3555
[5] Journal of Organic Chemistry, 1952, vol. 17, p. 149,153

8-METHYL-4-QUINAZOLONE Preparation Products And Raw materials

Raw materials

Preparation Products

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8-METHYL-4-QUINAZOLONE Suppliers

China 70 India 1 United Kingdom 2 United States 7 Global 80

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19181-54-5, 8-METHYL-4-QUINAZOLONERelated Search:

8-Quinazolinecarboxylic acid, 3,4-dihydro-4-oxo- 8-METHYL-4-QUINAZOLONE 4-HYDROXY-6-METHYLQUINAZOLINE 8-Chloro-2-methyl-4-quinazolone 2-Methyl-4-quinazolone 8-BROMO-6-METHYL-4-QUINAZOLONE 3-(8-METHYL-4-OXOQUINAZOLIN-3(4H)-YL)PROPANOIC ACID METHYL 4-OXO-3,4-DIHYDROQUINAZOLINE-8-CARBOXYLATE (8-METHYL-4-OXOQUINAZOLIN-3(4H)-YL)ACETIC ACID 5-METHYL-4-QUINAZOLONE 2-mercapto-3-(2-methoxyethyl)-8-methylquinazolin-4(3H)-one 2-mercapto-3,8-dimethylquinazolin-4(3H)-one 2-(CHLOROMETHYL)-8-METHYLQUINAZOLIN-4(3H)-ONE AURORA KA-6244 4-METHYL-7,8,9,10-TETRAHYDROAZEPINO[2,1-B]QUINAZOLIN-12(6H)-ONE OTAVA-BB BB7719100015 2-mercapto-8-methylquinazolin-4(3H)-one 2-(HYDROXYMETHYL)-8-METHYLQUINAZOLIN-4(3H)-ONE

8-METHYL-4-QUINAZOLONE

8-Methylquinazolin-4(3H)-one

8-Methylquinazolin-4-ol

8-Methylquinazolin-4(3H)-one 98%

8-METHYL-3H-QUINAZOLIN-4-ONE

8-methyl-4-quinazolinone

8-methylquinazolin-4(1H)-one

8-Methylquinazolin-4(3H)-one98%

8-Methylquinazolin-4(3H)

8-methyl-1H-quinazolin-4-one

8-Methyl-3,4-dihydroquinazolin-4-one

8-METHYL-4-QUINAZOLONE ISO 9001：2015 REACH

8-Methyl-4(3H)-Quinazolinone

19181-54-5

blocks

Heterocycles

Quinolines