METHYL PHOSPHORODICHLORIDITE Property

Melting point:

-91 °C (lit.)

Boiling point:

93-95 °C (lit.)

Density 

1.376 g/mL at 20 °C (lit.)

refractive index 

n20/D 1.474(lit.)

Flash point:

104 °F

storage temp. 

−20°C

solubility 

soluble in Chloroform, Dichloromethane, Ethyl Acetate

form 

liquid

color 

Colorless to Almost colorless

Water Solubility 

Reacts with water. Soluble in chloroform, dichloromethane and ethyl acetate.

Sensitive 

Moisture Sensitive

BRN 

1697452

Stability:

Flammable.

CAS DataBase Reference

3279-26-3(CAS DataBase Reference)

Safety

Hazard Codes 

C

Risk Statements 

10-14-34-37

Safety Statements 

26-36/37/39-45

RIDADR 

UN 2920 8/PG 2

WGK Germany 

3

F 

10-13-23

HazardClass 

8

PackingGroup 

II

HS Code 

29209090

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H226Flammable liquid and vapour

H314Causes severe skin burns and eye damage

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

METHYL PHOSPHORODICHLORIDITE Chemical Properties,Usage,Production

Chemical Properties

Colourless Liquid

Uses

Employed in the synthesis of phosphorodichloridothioates1 and oxazaphosphorinanes2 from sulfenyl chlorides and a chiral amino alcohol, respectively.

Uses

Methyl dichlorophosphite has been employed in the preparation of:

• phosphonamidate- and phosphonate-linked phosphonopeptides
• 2-(2-iodophenyl)ethyl methyl phosphite derivative of an alcohol
• deoxyoligonucleotides on a polymer support
• cis- and trans-2-oxo-2-propionyl-1,3,2-oxazaphosphorinane
• phosphorodichloridothioates
• oxazaphosphorinanes