ChemicalBook > CAS DataBase List > N-CBZ-4-PIPERIDINEPROPIONIC ACID

N-CBZ-4-PIPERIDINEPROPIONIC ACID

Product Name
N-CBZ-4-PIPERIDINEPROPIONIC ACID
CAS No.
63845-33-0
Chemical Name
N-CBZ-4-PIPERIDINEPROPIONIC ACID
Synonyms
3-(1-((Benzyloxy);1-Cbz-4-Piperidinepropionic Acid;N-CBZ-4-PIPERIDINEPROPIONIC ACID;3-(1-Cbz-4-piperidyl)propanoic Acid;3-(1-(benzyloxycarbonyl)piperidin-4-yl)propanoic acid;3-(1-phenylmethoxycarbonyl-4-piperidinyl)propanoic acid;4-Piperidinepropanoic acid, 1-[(phenylmethoxy)carbonyl]-;4-(2-CARBOXY-ETHYL)-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER
CBNumber
CB8353599
Molecular Formula
C16H21NO4
Formula Weight
291.34
MOL File
63845-33-0.mol
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N-CBZ-4-PIPERIDINEPROPIONIC ACID Property

Boiling point:
469.9±28.0 °C(Predicted)
Density 
1.191±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
4.73±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Biosynth Carbosynth
Product number
FC152877
Product name
N-Cbz-4-piperidinepropionicacid
Packaging
10mg
Price
$203
Updated
2021/12/16
AK Scientific
Product number
9778AB
Product name
3-(1-((Benzyloxy)carbonyl)piperidin-4-yl)propanoicacid
Packaging
1g
Price
$239
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC152877
Product name
N-Cbz-4-piperidinepropionicacid
Packaging
25mg
Price
$405
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC152877
Product name
N-Cbz-4-piperidinepropionicacid
Packaging
2mg
Price
$59
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC152877
Product name
N-Cbz-4-piperidinepropionicacid
Packaging
5mg
Price
$117
Updated
2021/12/16
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N-CBZ-4-PIPERIDINEPROPIONIC ACID Chemical Properties,Usage,Production

Synthesis

6318-43-0

501-53-1

63845-33-0

General procedure for the synthesis of 1-CBZ-4-piperidinepropionic acid from 3-(4-pyridyl)propionic acid and benzyl chloroformate: first, PIPERIDINE-HCL (6.5 g, 33.6 mmol) was dissolved in a mixed solvent of THF (300 mL) and saturated aqueous sodium bicarbonate (100 mL), and the reaction system was subsequently cooled to 0 °C. At this temperature, a solution of benzyl chloroformate (4.8 mL, 33.6 mmol) in THF (55 mL) was slowly added dropwise, and the dropwise process was controlled to be completed within 25 minutes. After the dropwise addition was completed, the reaction mixture was kept at 0 °C to continue the reaction for 6 hours. Upon completion of the reaction, the THF solvent was removed by vacuum concentration. Subsequently, the concentrated mixture was partitioned between chloroform and 3M HCl solution until gas escape ceased and the pH reached 2-3. The solid product was collected by filtration, while the filtrate was dried with anhydrous sodium sulfate and concentrated again under vacuum to give 1-(benzyloxymethyl)-4-piperidinonanoic acid (10 g, quantitative yield) as a light yellow oil.

References

[1] Patent: WO2004/58702, 2004, A2. Location in patent: Page 46; 27

N-CBZ-4-PIPERIDINEPROPIONIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from N-CBZ-4-PIPERIDINEPROPIONIC ACID manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
N-CBZ-4-PIPERIDINEPROPIONIC ACID 63845-33-0
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-10-10

63845-33-0, N-CBZ-4-PIPERIDINEPROPIONIC ACIDRelated Search:

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