4-Methyl-5-imidazolemethanol hydrochloride

Product Name: 4-Methyl-5-imidazolemethanol hydrochloride
CAS No.: 38585-62-5
Chemical Name: 4-Methyl-5-imidazolemethanol hydrochloride
Synonyms: 4-METHYL-5-IMIDAZOLEMETHANOL HCL;5(4)-METHYL-4(5)-IMIDAZOLE METHANOL;4-Methyl-5-HydroxymethylimidazoleHCl;5-HYDROXYMETHYL-4-METHYLIMIDAZOLE HCL;4-Hydroxymethyl-5-methylimidazole HCl;5-METHYL-4-HYDROXYMETHYL IMIDAZOLE HCL;Cimetidine Impurity I as Hydrochloride;4-Methyl-5-imidazolemethanol Hydrochlori;4-Methyl-5-imidazolemethanolhydrochilride;4-Methyl-5-imidazolemethanol hydrochlirde
CBNumber: CB8354228
Molecular Formula: C5H9ClN2O
Formula Weight: 148.59
MOL File: 38585-62-5.mol

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4-Methyl-5-imidazolemethanol hydrochloride Property

Melting point:: 233 °C (dec.)(lit.)
storage temp.: Inert atmosphere,Room Temperature
solubility: DMSO (Sparingly), Methanol (Slightly)
form: Crystalline Powder
color: Very slightly beige
CAS DataBase Reference: 38585-62-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37/39
WGK Germany: 3
HS Code: 29332900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 227420
Product name: 4-Methyl-5-imidazolemethanol hydrochloride
Purity: 97%
Packaging: 25g
Price: $80
Updated: 2023/01/07

TCI Chemical

Product number: H0625
Product name: 4-Hydroxymethyl-5-methylimidazole Hydrochloride
Purity: >98.0%(HPLC)(N)
Packaging: 25g
Price: $34
Updated: 2025/07/31

TRC

Product number: M313575
Product name: (4-Methyl-1H-imidazol-5-yl)methanolHydrochloride
Packaging: 2.5g
Price: $460
Updated: 2021/12/16

AK Scientific

Product number: Q195
Product name: 4-Methyl-5-imidazolemethanolHCl
Packaging: 100g
Price: $75
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK430665
Product name: 4-Methyl-5-imidazolemethanol hydrochloride
Purity: 98%
Packaging: 500g
Price: $427
Updated: 2021/12/16

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4-Methyl-5-imidazolemethanol hydrochloride Chemical Properties,Usage,Production

Chemical Properties

VERY SLIGHTLY BEIGE CRYSTALLINE POWDER

Uses

4-Methyl-5-imidazolemethanol hydrochloride was used in the synthesis of 1,3-bis(5-methyl-4-imidazolyl)-2-thiapropane (tridentate ligand).

Synthesis

60-29-7

51605-32-4

38585-62-5

1. Liquid ammonia is collected in a reactor under well ventilated conditions. Sodium metal (335 g, 15.23 mol) was added in batches and stirred until completely dissolved, forming a dark blue solution. This process takes about 15 minutes. 2. ethyl 4-methyl-5-imidazolecarboxylate (500 g, 3.25 mol) was suspended in 400 mL of anhydrous ethanol to form a wet powder. Over a period of about 30 minutes, this wet powder was carefully added in batches to the sodium-ammonia solution described above. 3. Upon completion of the addition, methanol (1 L) was slowly added. Subsequently, ammonium chloride (810 g, 15.28 mol) was added cautiously until the blue color of the solution faded, at which time the addition of the remaining ammonium chloride could be accelerated. 4. After the ammonium chloride has been added, the ammonia is evaporated using a cold water bath. Gradually increase the temperature of the water bath as the volume of the reaction mixture decreases. When most of the ammonia has been removed, switch to steam heating and remove the residual ammonia completely under vacuum, a process that takes 7-15 hours. 5. Isopropanol (6 L) was added to the residue and refluxed under vigorous stirring for 1 hour. Water (100 mL) was then added and stirring was continued for 10 minutes. 6. The mixture was cooled to about 40 °C, passed through hydrogen chloride gas to acidity and subsequently filtered. The filter cake was washed with hot isopropanol, and the filtrate was combined and concentrated to about 1 L. The mixture was then purged with acetone (4 L). 7. The concentrate was diluted with acetone (4 L) and ether (2 L) and the precipitated solid product was collected. Finally, the product was dried under vacuum at 60 °C to give 4-methyl-5-hydroxymethylimidazole hydrochloride in 94% yield.

References

[1] Patent: US4063023, 1977, A

4-Methyl-5-imidazolemethanol hydrochloride Preparation Products And Raw materials

Raw materials

Ethyl acetoacetate Industrial sulfuric acid ETHYL 5-METHYL-1H-IMIDAZOLE-4-CARBOXYLATE Sodium Ammonia

Preparation Products

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4-Methyl-5-imidazolemethanol hydrochloride Suppliers

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View Lastest Price from 4-Methyl-5-imidazolemethanol hydrochloride manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 4-Methyl-5-imidazolemethanol hydrochloride 38585-62-5
Price: US $0.00-0.00/KG
Min. Order: 1g
Purity: 99%
Supply Ability: 2000tons
Release date: 2019-12-31

Henan Fengda Chemical Co., Ltd

Product: 4-Methyl-5-imidazolemethanol hydrochloride 38585-62-5
Price: US $50.00-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-22

LY Global chemicals co.,ltd .

Product: 4-Methyl-5-imidazolemethanol hydrochloride 38585-62-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%-99%
Supply Ability: 1000kg
Release date: 2023-03-07

38585-62-5, 4-Methyl-5-imidazolemethanol hydrochlorideRelated Search:

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38585-62-5

C5H8N2OHCl

C5H9ClN2O

C5H8N2OHClC5H9ClN2O

ALCOHOL

Building Blocks

Heterocyclic Building Blocks

Imidazoles

Building Blocks

Heterocyclic Building Blocks

Imidazoles

Heterocyclic Compounds