Baclofen-d4
- Product Name
- Baclofen-d4
- CAS No.
- 1189938-30-4
- Chemical Name
- Baclofen-d4
- Synonyms
- [2H4]-Baclofen;(±)-Baclofen-d4 (4-chlorophenyl-d4);(+/-)-BACLOFEN (D4, 98%) 100 UG/ML IN METHANOL;Baclofen D4 HydrochlorideQ: What is Baclofen D4 Hydrochloride Q: What is the CAS Number of Baclofen D4 Hydrochloride Q: What is the storage condition of Baclofen D4 Hydrochloride Q: What are the applications of Baclofen D4 Hydrochloride
- CBNumber
- CB83586734
- Molecular Formula
- C10H8D4ClNO2
- Formula Weight
- 217.685427112
- MOL File
- 1189938-30-4.mol
Baclofen-d4 Property
- storage temp.
- Store at -20°C
- solubility
- Water: soluble
- form
- A solid
- Water Solubility
- Water: soluble
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335May cause respiratory irritation
H360May damage fertility or the unborn child
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P272Contaminated work clothing should not be allowed out of the workplace.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P284Wear respiratory protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313IF exposed or concerned: Get medical advice/attention.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P363Wash contaminated clothing before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 27811
- Product name
- (±)-Baclofen-d4
- Packaging
- 1mg
- Price
- $534
- Updated
- 2024/03/01
- Product number
- B108002
- Product name
- Baclofen-d4
- Packaging
- 10mg
- Price
- $2180
- Updated
- 2021/12/16
- Product number
- 5480DF
- Product name
- Baclofen-d4
- Packaging
- 1mg
- Price
- $692
- Updated
- 2021/12/16
Baclofen-d4 Chemical Properties,Usage,Production
Uses
Specific GABA-B receptor agonist. Muscle relaxant (skeletal).
Biological Activity
(±)-Baclofen-d4 is intended for use as an internal standard for the quantification of (±)-baclofen by GC- or LC-MS. (±)-Baclofen is a GABAB receptor agonist (IC50 = 180 nM).1 It induces norepinephrine release from isolated rat atria (IC50 = 4.5 μM). (±)-Baclofen (10 mg/kg) increases muscle rigidity in spastic mice.2 It inhibits the norepinephrine-induced group II flexor reflex in anesthetized rats.3 (±)-Baclofen also reduces cocaine-induced hyperlocomotion in rats and binge-like ethanol intake in mice.4,5 Formulations containing baclofen have been used to treat muscle spasms caused by multiple sclerosis and spinal cord injury.
References
1.Hill, D.R., and Bowery, N.G.3H-baclofen and 3H-GABA bind to bicuculline-insensitive GABAB sites in rat brainNature290(5802)(1981) 2.Biscoe, T.J., and Fry, J.P.Some pharmacological studies on the spastic mouseBr. J. Pharmacol. 75(1)23-25(1982) 3.Sakitani, K.The effects of centrally acting muscle relaxants on the intrathecal noradrenaline-induced facilitation of the flexor reflex mediated by group II afferent fibers in ratsJpn. J. Pharmacol.63(3)369-376(1993) 4.Lhuillier, L., Mombereau, C., Cryan, J.F., et al.GABAB receptor-positive modulation decreases selective molecular and behavioral effects of cocaineNeuropsychopharmacology32(2)388-398(2007) 5.Moore, E.M., and Boehm, S.L., IISite-specific microinjection of baclofen into the anterior ventral tegmental area reduces binge-like ethanol intake in male C57BL/6J miceBehav. Neurosci.123(3)555-563(2009)
Baclofen-d4 Preparation Products And Raw materials
Raw materials
Preparation Products
Baclofen-d4 Suppliers
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