ChemicalBook > CAS DataBase List > NS 1619

NS 1619

Product Name
NS 1619
CAS No.
153587-01-0
Chemical Name
NS 1619
Synonyms
NS 161;NS 1619;NS1619;NS 1619;NS-1619, 10 mM in DMSO;NS 1619, KCa1.1 channel activator;NS 1619 (1,3-DIHYDRO-1-(2-HYDROXY-5-(TRI FLUOROMETHYL)PHEN;1-(2-hydroxy-5-(trifluoroMethyl)phenyl)-5-(trifluoroMethyl)-1H-b;1-(2-Hydroxy-5-(Trifluoromethyl)Phenyl)-5-(Trifluoromethyl)-1H-Benzo[D]Imidazol-2-Ol;1-(2-hydroxy-5-(trifluoromethyl)phenyl)-5-(trifluoromethyl)-1H-benzo[d]imidazol-2(3H)-one;1,3-DIHYDRO-1-[2-HYDROXY-5-(TRIFLUOROMETHYL)PHENYL]-5-(TRIFLUOROMETHYL)-2H-BENZIMIDAZOL-2-ONE
CBNumber
CB8359809
Molecular Formula
C15H8F6N2O2
Formula Weight
362.23
MOL File
153587-01-0.mol
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NS 1619 Property

Density 
1.563±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,2-8°C
solubility 
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.47 mg/mL
pka
8.32±0.48(Predicted)
form 
solid
color 
white
Water Solubility 
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.47mg/mL
ethanol: 26.6mg/mL
0.1 M NaOH: 5.2mg/mL
DMSO: 5.3mg/mL
H2O: insoluble
InChI
InChI=1S/C15H8F6N2O2/c16-14(17,18)7-1-3-10-9(5-7)22-13(25)23(10)11-6-8(15(19,20)21)2-4-12(11)24/h1-6,24H,(H,22,25)
InChIKey
YLFMCMWKHSDUCT-UHFFFAOYSA-N
SMILES
C1(=O)N(C2=CC(C(F)(F)F)=CC=C2O)C2=CC=C(C(F)(F)F)C=C2N1
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
N170
Product name
NS 1619
Purity
powder
Packaging
5mg
Price
$183.91
Updated
2025/07/31
Sigma-Aldrich
Product number
N170
Product name
NS 1619
Purity
powder
Packaging
25mg
Price
$663
Updated
2025/07/31
TCI Chemical
Product number
N1191
Product name
NS-1619
Purity
min. 95.0 %
Packaging
10MG
Price
$157
Updated
2025/07/31
TCI Chemical
Product number
N1191
Product name
NS-1619
Purity
min. 95.0 %
Packaging
50MG
Price
$469
Updated
2025/07/31
Cayman Chemical
Product number
18876
Product name
NS 1619
Purity
≥98%
Packaging
1mg
Price
$37
Updated
2024/03/01
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NS 1619 Chemical Properties,Usage,Production

Uses

NS 1619 is a large conductance calcium-activated potassium channels (BKCa) activator and has been shown to induce precondition in the heart.

Definition

ChEBI: A member of the class of benzimidazoles that is 1,3-dihydro-2H-benzimidazol-2-one in which the hydrogens at positions 1 and 5 are replaced are replaced by 2-hydroxy-5-(trifluoromethyl)phenyl and trifluoromethyl groups, respectively. It i an opener/activator of the large-conductance calcium-activated potassium channel (Bkca).

Biochem/physiol Actions

NS 1619 is a selective large conductance Ca2+-activated K+-channel activator. The compound is known for its vasodilating and anti-proliferative properties. It is studied that NS 1619 can protect cardiac muscle against ischemia and reperfusion injury.

in vivo

Opening of KCa channels with NS-1619 (1 mg/kg; i.p.) can delay protection in mouse hearts[3].

Animal Model:Adult male outbred ICR mice[3]
Dosage:1 mg/kg
Administration:Pretreated i.p. 24 h before I/R
Result:Pretreatment induced delayed protection 24 h later.
Resulted in significant cardioprotection 24 h later, i.e., infarct size was reduced from 38.8 ± 3.7% to 19.8 ± 2.9%.

storage

+4°C

NS 1619 Preparation Products And Raw materials

Raw materials

Preparation Products

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NS 1619 Suppliers

China 92 Europe 1 India 2 Japan 1 Switzerland 1 United Kingdom 4 United States 18 Global 119
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View Lastest Price from NS 1619 manufacturers

Career Henan Chemical Co
Product
NS 1619 153587-01-0
Price
US $9.80/KG
Min. Order
1g
Purity
≥99%
Supply Ability
100kg
Release date
2020-01-13

153587-01-0, NS 1619Related Search:

Glibenclamide Nicorandil CHARYBDOTOXIN NS-6180 Adenosine 5'-[γ-thio]triphosphate TetralithiuM Salt APAMIN PENITREM A NS1643 PNU 37883 hydrochloride TRAM-34 5-HYDROXYDECANOIC ACID SODIUM SALT CLOFILIUM TOSYLATE Gabapentin-lactam PAXILLINE 2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole NS 11394 Selexipag N-(4-PHENYLSULFONYLPHENYL)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPANAMIDE

  • NS 1619
  • NS 1619 (1,3-DIHYDRO-1-(2-HYDROXY-5-(TRI FLUOROMETHYL)PHEN
  • 1,3-DIHYDRO-1-[2-HYDROXY-5-(TRIFLUOROMETHYL)PHENYL]-5-(TRIFLUOROMETHYL)-2H-BENZIMIDAZOL-2-ONE
  • 1-(2-hydroxy-5-(trifluoromethyl)phenyl)-5-(trifluoromethyl)-1H-benzo[d]imidazol-2(3H)-one
  • 1-(2-hydroxy-5-(trifluoroMethyl)phenyl)-5-(trifluoroMethyl)-1H-b
  • NS1619;NS 1619
  • NS 161
  • 2H-Benzimidazol-2-one, 1,3-dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-
  • 1-[2-Hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-1,3-dihydro-2H-benzimidazol-2-one
  • 1-[2-Hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-1,3-dihydro-2H-benzo[d]imidazol-2-one
  • 1-(2-Hydroxy-5-(Trifluoromethyl)Phenyl)-5-(Trifluoromethyl)-1H-Benzo[D]Imidazol-2-Ol
  • NS 1619, KCa1.1 channel activator
  • NS-1619, 10 mM in DMSO
  • 153587-01-0
  • C15H8F6N2O2
  • Monovalent Ion Channels
  • Ion Channels
  • Voltage-gated Ion Channels
  • Potassium Channel Modulators
  • Cell Signaling and Neuroscience
  • Cell Biology
  • BioChemical
  • API