5,6-Difluoro-2-oxoindole
- Product Name
- 5,6-Difluoro-2-oxoindole
- CAS No.
- 71294-07-0
- Chemical Name
- 5,6-Difluoro-2-oxoindole
- Synonyms
- 5,6-Difluorooxindol;5,6-DIFLUOROOXINDOLE;5,6-Difluoro-2-oxindole;5,6-Difluoro-2-oxoindole;5,6-difluoroindolin-2-one;5,6-Difluorooxindole 95+%;5,6-difluoro-2,3-dihydro-1H-indol-2-one;5,6-Difluoro-1,3-dihydro-2H-indol-2-one;2H-Indol-2-one, 5,6-difluoro-1,3-dihydro-;5,6-difluoro-2,3-dihydro-1H-indol-2-one - [D87305]
- CBNumber
- CB8364771
- Molecular Formula
- C8H5F2NO
- Formula Weight
- 169.13
- MOL File
- 71294-07-0.mol
5,6-Difluoro-2-oxoindole Property
- Melting point:
- 201-202 °C(Solv: benzene (71-43-2))
- Boiling point:
- 285.3±40.0 °C(Predicted)
- Density
- 1.415±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 11.88±0.20(Predicted)
- Appearance
- Yellow to brown Solid
- InChI
- InChI=1S/C8H5F2NO/c9-5-1-4-2-8(12)11-7(4)3-6(5)10/h1,3H,2H2,(H,11,12)
- InChIKey
- MSOLDJZABLHVER-UHFFFAOYSA-N
- SMILES
- N1C2=C(C=C(F)C(F)=C2)CC1=O
- CAS DataBase Reference
- 71294-07-0(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 26-36/37/39
- HS Code
- 2933790090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D445768
- Product name
- 5,6-Difluorooxindole
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- PC3025
- Product name
- 5,6-Difluorooxindole
- Purity
- 95+%
- Packaging
- 1g
- Price
- $85
- Updated
- 2021/12/16
- Product number
- 4H48-3-Y2
- Product name
- 5,6-Difluorooxindole
- Packaging
- 1g
- Price
- $136
- Updated
- 2021/12/16
- Product number
- N456
- Product name
- 5,6-Difluoro-2-oxoindole
- Packaging
- 1g
- Price
- $157
- Updated
- 2021/12/16
- Product number
- HCH0024242
- Product name
- 5,6-DIFLUOROOXINDOLE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $757
- Updated
- 2021/12/16
5,6-Difluoro-2-oxoindole Chemical Properties,Usage,Production
Synthesis
774-47-0
71294-07-0
General procedure for the synthesis of 5,6-difluoroindolin-2,3-dione from 5,6-difluoroindolin-2-one: TiCl4 (0.7 mL, 6 mmol) was added drop-wise to a stirring suspension of Zn powder (0.78 g, 12 mmol) in freshly distilled anhydrous THF (15 mL) at room temperature and under dry N2 atmosphere. After addition, the mixture was refluxed for 2 hours. The resulting suspension of low-valent titanium reagent was cooled to room temperature. Subsequently, a solution of 5,6-difluoroindoline-2,3-dione (2 mmol) in THF (10 mL) was slowly added. The reaction mixture was stirred at room temperature for about 5 min under N2 protection. After confirming the completion of the reaction by thin layer chromatography (TLC) analysis, the reaction was quenched with 3% HCl (15 mL) and extracted with CHCl3 (3 x 50 mL). The organic phases were combined, washed with water (3 x 50 mL) and dried over anhydrous Na2SO4. After concentration of the solvent under reduced pressure, the crude product was purified by column chromatography (petroleum ether/ethyl acetate=5:1) to afford the target compound 5,6-difluoroindol-2-one.
References
[1] Tetrahedron Letters, 2014, vol. 55, # 14, p. 2238 - 2242
[2] Journal of Chemical Research, 2017, vol. 41, # 9, p. 537 - 540
5,6-Difluoro-2-oxoindole Preparation Products And Raw materials
Raw materials
Preparation Products
5,6-Difluoro-2-oxoindole Suppliers
- Tel
- +86 (0) 571 85 58 67 18
- Fax
- 0086-571-85864795
- Country
- China
- ProdList
- 18207
- Advantage
- 66
- Tel
- 13817811078
- Fax
- 86-021-50426522,50426273
- sales@jingyan-chemical.com
- Country
- China
- ProdList
- 9976
- Advantage
- 60
- Tel
- 86-0571-85151182
- Fax
- 86-0571-85151182
- Country
- China
- ProdList
- 5691
- Advantage
- 66
- Tel
- 0571-82693216
- Fax
- +86-571-82880190
- info@yuhaochemical.com
- Country
- China
- ProdList
- 6387
- Advantage
- 52
- Tel
- 18652989687
- Fax
- +86-25-52131256
- sales@norris-pharm.com
- Country
- China
- ProdList
- 8878
- Advantage
- 55
- Tel
- 021-62960152
- Fax
- 021-52212593
- 934678158@qq.com
- Country
- China
- ProdList
- 9899
- Advantage
- 55
- Tel
- +86-021-50935922
- Fax
- +86-021-33847795
- Country
- China
- ProdList
- 7865
- Advantage
- 55
- Tel
- 021-57171705 13817537615
- Fax
- QQ3095748324
- sales@run-biotech.com
- Country
- China
- ProdList
- 2339
- Advantage
- 58
- Tel
- 0519-0519-83812535
- sales@qinuochem.com
- Country
- China
- ProdList
- 287
- Advantage
- 60
- Tel
- 微信 17321281695 18019252918
- Fax
- 17321281695
- sale@amkchem.com
- Country
- China
- ProdList
- 15136
- Advantage
- 55
View Lastest Price from 5,6-Difluoro-2-oxoindole manufacturers
- Product
- 5,6-Difluoro-2-oxoindole 71294-07-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%HPLC
- Supply Ability
- 10 tons/month
- Release date
- 2020-01-07