ChemicalBook > CAS DataBase List > 5,6-Difluoro-2-oxoindole

5,6-Difluoro-2-oxoindole

Product Name
5,6-Difluoro-2-oxoindole
CAS No.
71294-07-0
Chemical Name
5,6-Difluoro-2-oxoindole
Synonyms
5,6-Difluorooxindol;5,6-DIFLUOROOXINDOLE;5,6-Difluoro-2-oxindole;5,6-Difluoro-2-oxoindole;5,6-difluoroindolin-2-one;5,6-Difluorooxindole 95+%;5,6-difluoro-2,3-dihydro-1H-indol-2-one;5,6-Difluoro-1,3-dihydro-2H-indol-2-one;2H-Indol-2-one, 5,6-difluoro-1,3-dihydro-;5,6-difluoro-2,3-dihydro-1H-indol-2-one - [D87305]
CBNumber
CB8364771
Molecular Formula
C8H5F2NO
Formula Weight
169.13
MOL File
71294-07-0.mol
More
Less

5,6-Difluoro-2-oxoindole Property

Melting point:
201-202 °C(Solv: benzene (71-43-2))
Boiling point:
285.3±40.0 °C(Predicted)
Density 
1.415±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
11.88±0.20(Predicted)
Appearance
Yellow to brown Solid
InChI
InChI=1S/C8H5F2NO/c9-5-1-4-2-8(12)11-7(4)3-6(5)10/h1,3H,2H2,(H,11,12)
InChIKey
MSOLDJZABLHVER-UHFFFAOYSA-N
SMILES
N1C2=C(C=C(F)C(F)=C2)CC1=O
CAS DataBase Reference
71294-07-0(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xi,Xn
Risk Statements 
20/21/22-36/37/38
Safety Statements 
26-36/37/39
HS Code 
2933790090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

TRC
Product number
D445768
Product name
5,6-Difluorooxindole
Packaging
50mg
Price
$45
Updated
2021/12/16
Apolloscientific
Product number
PC3025
Product name
5,6-Difluorooxindole
Purity
95+%
Packaging
1g
Price
$85
Updated
2021/12/16
SynQuest Laboratories
Product number
4H48-3-Y2
Product name
5,6-Difluorooxindole
Packaging
1g
Price
$136
Updated
2021/12/16
AK Scientific
Product number
N456
Product name
5,6-Difluoro-2-oxoindole
Packaging
1g
Price
$157
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0024242
Product name
5,6-DIFLUOROOXINDOLE
Purity
95.00%
Packaging
1G
Price
$757
Updated
2021/12/16
More
Less

5,6-Difluoro-2-oxoindole Chemical Properties,Usage,Production

Synthesis

774-47-0

71294-07-0

General procedure for the synthesis of 5,6-difluoroindolin-2,3-dione from 5,6-difluoroindolin-2-one: TiCl4 (0.7 mL, 6 mmol) was added drop-wise to a stirring suspension of Zn powder (0.78 g, 12 mmol) in freshly distilled anhydrous THF (15 mL) at room temperature and under dry N2 atmosphere. After addition, the mixture was refluxed for 2 hours. The resulting suspension of low-valent titanium reagent was cooled to room temperature. Subsequently, a solution of 5,6-difluoroindoline-2,3-dione (2 mmol) in THF (10 mL) was slowly added. The reaction mixture was stirred at room temperature for about 5 min under N2 protection. After confirming the completion of the reaction by thin layer chromatography (TLC) analysis, the reaction was quenched with 3% HCl (15 mL) and extracted with CHCl3 (3 x 50 mL). The organic phases were combined, washed with water (3 x 50 mL) and dried over anhydrous Na2SO4. After concentration of the solvent under reduced pressure, the crude product was purified by column chromatography (petroleum ether/ethyl acetate=5:1) to afford the target compound 5,6-difluoroindol-2-one.

References

[1] Tetrahedron Letters, 2014, vol. 55, # 14, p. 2238 - 2242
[2] Journal of Chemical Research, 2017, vol. 41, # 9, p. 537 - 540

5,6-Difluoro-2-oxoindole Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

5,6-Difluoro-2-oxoindole Suppliers

China 88 France 1 Germany 2 United Kingdom 8 United States 15 Global 114
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Country
China
ProdList
18207
Advantage
66
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9976
Advantage
60
China DongFan Chemical Co.,LTD
Tel
86-0571-85151182
Fax
86-0571-85151182
Country
China
ProdList
5691
Advantage
66
Hangzhou Yuhao Chemical Technology Co., Ltd
Tel
0571-82693216
Fax
+86-571-82880190
Email
info@yuhaochemical.com
Country
China
ProdList
6387
Advantage
52
Nanjing Norris-Pharm Technology Co., Ltd
Tel
18652989687
Fax
+86-25-52131256
Email
sales@norris-pharm.com
Country
China
ProdList
8878
Advantage
55
Shanghai Yolne Chemical Co., Ltd.
Tel
021-62960152
Fax
021-52212593
Email
934678158@qq.com
Country
China
ProdList
9899
Advantage
55
Shanghai Raise Chemical Technology Co.,Ltd
Tel
+86-021-50935922
Fax
+86-021-33847795
Country
China
ProdList
7865
Advantage
55
Shanghai Run-Biotech Co., Ltd.
Tel
021-57171705 13817537615
Fax
QQ3095748324
Email
sales@run-biotech.com
Country
China
ProdList
2334
Advantage
58
Changzhou Qinuo Chemical Co., Ltd.Co., Ltd.
Tel
0519-0519-83812535
Email
sales@qinuochem.com
Country
China
ProdList
287
Advantage
60
ShangHai AmK Pharmaceutical Technology Co., Ltd.
Tel
微信 17321281695 18019252918
Fax
17321281695
Email
sale@amkchem.com
Country
China
ProdList
15136
Advantage
55
Shanghai Yongye Biotechnology Co., Ltd.
Tel
86-021-61559134 15921386130
Fax
021-55068248
Email
3423497944@qq.com
Country
China
ProdList
8144
Advantage
55
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66028182 18626450290
Email
yftan@aikonchem.com
Country
China
ProdList
16679
Advantage
50
Hangzhou Milestone Pharmtech Co., Ltd.
Tel
0571-82896630 18969958410
Email
sales_hz@milestonepharmtech.com
Country
China
ProdList
4894
Advantage
55
AN PharmaTech Co Ltd
Tel
86(21)68097365
Fax
86(21)33321566
Email
sales@anpharma.net
Country
China
ProdList
4891
Advantage
55
Chemwill Asia Co.,Ltd.
Tel
86-21-51086038
Fax
86-21-51861608
Email
sales@chemwill.com
Country
China
ProdList
1974
Advantage
58
Henan CoreyChem Co., Ltd
Tel
0371-86658258
Fax
0371-60996044
Email
info@coreychem.com
Country
China
ProdList
10453
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Hangzhou Molcore Biopharmatech Co.,Ltd
Tel
400-711-5280 86-571-81025280
Fax
86-571-85806285
Email
sales@molcore.com
Country
China
ProdList
9967
Advantage
58
Biokitchen
Tel
021-021-021-31663258 13795219287
Fax
021-31663258
Email
donghuanwen@126.com
Country
China
ProdList
8816
Advantage
58
Capot Chemical Co.,Ltd.
Tel
+86-（0）57185586718; +8613336195806
Fax
+86-571-85864795
Email
sales@capot.com
Country
China
ProdList
29735
Advantage
60
Hubei Xinyuanshun Pharmaceutical Chemical Co., Ltd.
Tel
027-51831887 15337167856
Fax
027-51837635 QQ1165326703
Email
hubeixinyuanshun@163.com
Country
China
ProdList
10295
Advantage
58
Shanghai Jizhi Biochemical Technology Co. Ltd.
Tel
4009004166/18616739031 18616739031
Email
3007523370@qq.com
Country
China
ProdList
52687
Advantage
58
Shanghai FWD Chemicals Limited
Tel
021-54450827 021-54450828
Email
sales@fwdchem.com
Country
China
ProdList
997
Advantage
58
Jinan Carbotang Biotech Co.,Ltd.
Tel
+8615866703830
Email
figo.gao@foxmail.com
Country
China
ProdList
8497
Advantage
58
Allfluoro pharmaceutical co. ltd.
Tel
+86-400-0216110 +86-15958047586
Fax
0086-21-33275002
Email
sales@allfluoro.com
Country
China
ProdList
11385
Advantage
58
Hefei TNJ Chemical Industry Co.,Ltd.
Tel
+86-0551-65418684 +8618949823763
Fax
0086-551-65418684
Email
sales@tnjchem.com
Country
China
ProdList
25356
Advantage
58
Dayang Chem (Hangzhou) Co.,Ltd.
Tel
+86-0571-88938639 +8617705817739
Fax
+86-571-88938652，+86-571- 88492614
Email
info@dycnchem.com
Country
China
ProdList
52846
Advantage
58
Career Henan Chemica Co
Tel
+86-0371-86658258 +8613203830695
Fax
0371-86658258
Email
laboratory@coreychem.com
Country
China
ProdList
30229
Advantage
58
SIMAGCHEM CORP
Tel
+86-5922680277 +86-13806087780
Email
sale@simagchem.com
Country
China
ProdList
17346
Advantage
58
Chemwill Asia Co.,Ltd.
Tel
86-21-51086038
Fax
86-21-51861608
Email
chemwill_asia@126.com
Country
CHINA
ProdList
23912
Advantage
58
Changzhou Ditong Chemical Co.,Ltd
Tel
+86-0519-88299272
Email
info@edengenechem.com
Country
China
ProdList
2176
Advantage
58
Guangdong Wengjiang Chemical Reagent Co., Ltd.
Tel
0751-2886766 13927870850
Fax
0751-2886756
Email
3001267247@qq.com
Country
China
ProdList
9941
Advantage
58
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Email
sales@accelachem.com
Country
China
ProdList
10467
Advantage
58
CONIER CHEM AND PHARMA LIMITED
Tel
+8618523575427
Email
sales@conier.com
Country
China
ProdList
49975
Advantage
58
career henan chemical co
Tel
+86-0371-86658258 +8613203830695
Fax
0086-371-86658258
Email
factory@coreychem.com
Country
China
ProdList
29798
Advantage
58
Taizhou Nanfeng Pharmaceutical Research Institute
Tel
nanfengdrug@163.com; 18616377689
Email
nanfengdrug@163.com
Country
China
ProdList
20009
Advantage
58
Changzhou Kechem Bio-Scientific Co., LTD.
Tel
0519-68985668 13685222090
Fax
qq735434464
Email
sales@kechem.cn
Country
China
ProdList
26028
Advantage
58
Henan Weitesi Chemical Technology Co. LTD
Tel
0371-0371-55135753 18003832934
Fax
QQ：2853979818
Email
2853979818@qq.com
Country
China
ProdList
9991
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
Country
China
ProdList
44918
Advantage
58
Mainchem Co., Ltd.
Tel
--
Fax
--
Email
sarah@mainchem.com
Country
China
ProdList
6547
Advantage
58
Shanghai Sunway Pharmaceutical Technology Co.,Ltd.
Tel
021-51816796-820 13611835272
Fax
021-5161 3951
Email
sales2@sunwaypharm.com
Country
China
ProdList
44119
Advantage
58
Hebei Weite Medical Technology Co., Ltd
Tel
13180081292 13180081292
Email
contact@wetogethermed.com
Country
China
ProdList
7948
Advantage
58
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 4008210725
Email
malulu@leyan.com
Country
China
ProdList
40000
Advantage
58
PharmaBlock Sciences (Nanjing), Inc.
Tel
4000255188
Fax
025 86918232
Email
sales_china@pharmablock.com
Country
China
ProdList
10000
Advantage
58
Bide Pharmatech Ltd.
Tel
400-6005915
Email
sales@picasso-e.com
Country
China
ProdList
39665
Advantage
58
Shanghai Lingfu Pharmaceutical Research Co. LTD
Tel
+86(21)5895 0110 19945755304
Email
sales@chemany.com
Country
China
ProdList
9984
Advantage
58
Zhanhua Huibang Chemical Co., Ltd.
Tel
13906149256
Email
793211102@qq.com
Country
China
ProdList
143
Advantage
58
Suzhou Qihang Biotechnology Co., Ltd
Tel
18151111370
Email
1046215251@qq.com
Country
China
ProdList
8718
Advantage
58
Shanghai Jieshikai Biotechnology Co. , Ltd.
Tel
021-57520305 13795461237
Email
zhuruyan@jskchem.com
Country
China
ProdList
49234
Advantage
58
More
Less

View Lastest Price from 5,6-Difluoro-2-oxoindole manufacturers

Career Henan Chemical Co
Product
5,6-Difluoro-2-oxoindole 71294-07-0
Price
US $1.00/KG
Min. Order
1KG
Purity
98%HPLC
Supply Ability
10 tons/month
Release date
2020-01-07

71294-07-0, 5,6-Difluoro-2-oxoindoleRelated Search:

Dehydroepiandrosterone cis-Octahydroisoindole Naringin dihydrochalcone Isophorone 1-(2,6-Dichlorophenyl)-2-hydroindole 5,6-DIFLUOROISATIN 4,6-Difluoro-2-oxoindole 5,6,7-trifluoro-1H-indole-2,3-dione BUTTPARK 89\07-57 4,5,6-TRIFLUOROINDOLINE-2,3-DIONE 5,6-Difluoro-2-oxoindole

  • 5,6-DIFLUOROOXINDOLE
  • 5,6-Difluoro-2-oxoindole
  • 5,6-Difluoro-1,3-dihydro-2H-indol-2-one
  • 5,6-Difluorooxindole 95+%
  • 5,6-difluoroindolin-2-one
  • 5,6-Difluoro-2-oxindole
  • 5,6-difluoro-2,3-dihydro-1H-indol-2-one
  • 5,6-Difluorooxindol
  • 2H-Indol-2-one, 5,6-difluoro-1,3-dihydro-
  • 5,6-difluoro-2,3-dihydro-1H-indol-2-one - [D87305]
  • 71294-07-0
  • 71294-07-5
  • 77294-07-0
  • 71294-07-7
  • C8H5F2NO
  • Boronic Acid
  • Heterocyclic Compounds
  • Indoles
  • Indole/indoline/oxindole
  • Indole and Indoline
  • Indole