Androstenedione

Biological Metabolism

Product Name: Androstenedione
CAS No.: 63-05-8
Chemical Name: Androstenedione
Synonyms: 4-AD;4-ANDROSTENEDIONE;4-ANDROSTENE-3,17-DIONE;ANDROSTENDIONE;ANDROSTA-4-ENE-3,17-DIONE;Androstenedione (CRM);skf2170;ANDROTEX;SKF 2170;Fecundin
CBNumber: CB8365581
Molecular Formula: C19H26O2
Formula Weight: 286.41
MOL File: 63-05-8.mol

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Androstenedione Property

Melting point:: 170-171 °C(lit.)
Boiling point:: 368.77°C (rough estimate)
alpha: D30 +199° (in chloroform)
Density: 1.0655 (rough estimate)
refractive index: 1.4709 (estimate)
Flash point:: 2℃
storage temp.: Controlled Substance, -20°C Freezer
solubility: Chloroform (Slightly), Ethanol (Slightly, Sonicated), Methanol (Sparingly)
form: Solid
color: Dimorphous: Needles from acetone, or crystalsfrom hexane
Water Solubility: 57.28mg/L(25 ºC)
Merck: 13,643
InChIKey: AEMFNILZOJDQLW-QAGGRKNESA-N
CAS DataBase Reference: 63-05-8(CAS DataBase Reference)
NIST Chemistry Reference: Androst-4-ene-3,17-dione(63-05-8)
EPA Substance Registry System: 4-Androstenedione (63-05-8)

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Safety

Hazard Codes: Xn,T,F
Risk Statements: 40-64-52-22-61-60-36-20/21/22-11
Safety Statements: 22-24/25-36-45-36/37-53-26-16
RIDADR: UN 1648 3 / PGII
WGK Germany: 3
RTECS: BV8150000
HS Code: 29372900
Hazardous Substances Data: 63-05-8(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2364
Product name: 4-Androstenedione
Purity: ≥98% (HPLC)
Packaging: 250MG
Price: $63
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML2364
Product name: 4-Androstenedione
Purity: ≥98% (HPLC)
Packaging: 500MG
Price: $121
Updated: 2025/07/31

Sigma-Aldrich

Product number: PHR8811
Product name: Testosterone Related Compound A
Purity: certified reference material, pharmaceutical secondary standard
Packaging: 50 mg
Price: $517
Updated: 2025/07/31

Sigma-Aldrich

Product number: PHL89562
Product name: Androstenedione
Purity: phyproof? Reference Substance
Packaging: 100MG
Price: $179
Updated: 2025/07/31

Sigma-Aldrich

Product number: A-075
Product name: Androstenedione solution
Purity: 1.0?mg/mL in acetonitrile, ampule of 1?mL, certified reference material, Cerilliant?
Packaging: 1mL
Price: $52.4
Updated: 2025/07/31

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Androstenedione Chemical Properties,Usage,Production

Biological Metabolism

The in vitro perfusion of the human placental lobule with 7-ethoxycoumarin gives 7-hydroxycoumarin, and perfusion with androstenedione gives the conversion products, estrone, estradiol, and testosterone. The human placenta has only a limited capacity for the metabolism of xenobiotics.

Description

Androstenedione (CRM) (Item No. ISO60161) is a certified reference material categorized as an anabolic androgenic steroid. Androstenedione is a precursor of testosterone (Item Nos. ISO60154 | ISO00154 | 15645) and estrone . Androstenedione is regulated as a Schedule III compound in the United States. Androstenedione (CRM) (Item No. ISO60161) is provided as a DEA exempt preparation. This product is intended for research and forensic applications.

Chemical Properties

White to Off-White Solid

Uses

Testosterone precursor and metabolite with androgenic activity. Controlled substance (anabolic sterid)

Definition

ChEBI: A 3-oxo Delta4-steroid that is androst-4-ene substituted by oxo groups at positions 3 and 17. It is a steroid hormone synthesized in the adrenal glands and gonads.

Safety Profile

An experimental teratogen. Otherexperimental reproductive effects. Questionablecarcinogen with experimental tumorigenic data. Whenheated to decomposition it emits acrid smoke andirritating fumes.

Purification Methods

Crystallise the dione from hexane. It is soluble in *C6H6, CHCl3 and EtOH. It has max at 239nm. It is a precursor of estrone or testosterone and has androgenic activity. [Ruzicka & Wettstein Helv Chim Acta 18 980 1935, Beilstein 7 III 3636, 7 IV 2381.]

Toxics Screening Level

The initial threshold screening level (ITSL) for androstenedione is 17 μg/m3 based on an annual averaging time.

References

[1] F. CHEN. Partial agonist/antagonist properties of androstenedione and 4-androsten-3β,17β-diol[J]. Journal of Steroid Biochemistry and Molecular Biology, 2004, 91 4: Pages 247-257. DOI: 10.1016/j.jsbmb.2004.04.009
[2] Toxicology and carcinogenesis studies of androstenedione (CAS No. 63-05-8) in F344/N rats and B6C3F1 mice (gavage studies).[J]. National Toxicology Program technical report series, 2010, 560: 1, 7-31,33-171 passim.
[3] OSTOJI? S, CALLEJA-GONZáLEZ J, STOJANOVI? M. Steroid Prohormones: Effects on Body Composition in Athletes[C]. 2011: 0. DOI: 10.5772/28543

Androstenedione Preparation Products And Raw materials

Raw materials

Preparation Products

Spironolactone

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Androstenedione Suppliers

Canada 2 China 285 Europe 1 France 1 Germany 3 India 7 Japan 1 Switzerland 1 United Kingdom 7 United States 19 Global 327

ALB Technology Limited

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United States Biological

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Cayman Chemical Company

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Matrix Scientific

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Fragmenta

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Kingchem Inc.

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American Radiolabeled Chemicals, Inc.

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Cerilliant Corporation

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Waterstone Technology, LLC

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View Lastest Price from Androstenedione manufacturers

Wuhan Biocar Pharmacy CO.,Ltd.

Product: 4-Androstenedione 63-05-8
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 5000KG
Release date: 2025-02-26

Hebei Yanxi Chemical Co., Ltd.

Product: Androstenedione 63-05-8
Price: US $40.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 10 tons
Release date: 2023-09-12

Wuhan Xinhao Biotechnology Co., Ltd

Product: Androst-4-ene-3,17-dione 63-05-8
Price: US $10.00-100.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100 tons
Release date: 2024-01-17

63-05-8, AndrostenedioneRelated Search:

Androstenedione-3,17-Dione 6-METHYLENEANDROST-4-ENE-3,17-DIONE 2,2-Dimethyl-1,3-propanediol 1-ChloroMethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate) 1-Bromopentane Bromoacetonitrile PotassiuM triMethylacetate, 95% ZINC-COPPER COUPLE Exemestane Impurity 13 Exemestane impurity B -F 17-Beta-Hydroxy Exemestane Epoxide Androstenediol Exemestane 6-Oxo Boldione ExeMestane Related CoMpound Exemestane Impurity 1 Exemestane Impurity 11 androstane-3,6,17-triol

3,17-Dioxoandrost-4-Ene

Androstenedione (CRM)

Testosterone EP Impurity A

4-Androstene-3

4-androsten-3,17-dione (4-AD)

4-Androstene-3,17-dione Solution, 100ppm

Androstenedione solution

4-androstene-3,17-dione(4-AD)

Androstenedione solution,100ppm

(8R,9S,10R,13S,14S)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17-dione

(8R,9S,10R,13S,14S)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17-quinone

(8R,9S,10R,13S,14S)-10,13-dimethyl-7,8,9,10,11,12,13,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17(2H,6H)-dione

4-AD

(+)-4-ANDROSTEN-3,17-DIONE

4-ANDROSTEN-3,17-DIONE

4-ANDROSTENE-3,17-DIONE

4-ANDROSTENEDIONE

ANDROSTENDIONE

ANDROTEX

ANDROSTENEDIONE

ANDROST-4-ENE-3, 17-DIONE

ANDROST-4-ENE-3,17-DIONE, 10,13-DIMETHYL-2,6,7,8,9,11,12,14,15,16-DECAHYDRO-1H-CYCLOPENTA[A]PHENANTHRENE-3,17-DIONE

ANDROSTA-4-ENE-3,17-DIONE

delta-(sup4)-Androsten-3,17-dione

delta(Sup4)-Androstene-3,17-dione

delta4-androsten-3,17-dione

delta-4-androstenedione

SKF 2170

skf2170

(8R,9S,10R,13S,14S)-10,13-DIMETHYL-1,6,7,8,9,10,11,12,13,14,15,16-DODECAHYDRO-2H-CYCLOPENTA[A]PHENANTHRENE-3,17-DIONE

3,17-DIOXO-4-ANDROSTENE

Androsten-3,17-dione

Androstenedione (JAN)

Androstenedione 4-AD

Androstenedione 10,13-dimethyl-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]ph 10,13-Dimethyl-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,17-dione

Testosterone Impurity 1(Testosterone EP Impurity A)

10,13-DIMETHYL-2,3,6,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-1H-CYCLOPENTA[A]PHENANTHRENE-3,17-DIONE

4-Androstenedione(4AD)

17-Ketotestosterone

Fecundin

NSC 9563

ndrostenedione

10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17-dione

ANDROSTENEDIONE(SH)

4-ANDROSTENEDIONE(ANDROSTENEDIONE)

DELTA-ANDROSTEN-3,17-DIONE

DELTA4-ANDROSTENE-3,17-DIONE

4-ANDROSTENE-3,1,7-DIONE, FROM DIOSCOREA OPPOSITA THUNB.99%(HPLC)

4-ANDROSTENE-3,17-DIONE 98.5+%

4-ANDROSTENEDIONE 99% MIN

(4-AD)4-ANDROSTENEDIONE

4-ANDROSTENEDIONE (4-ANDROSTENE-3,17-DIONE)

Androst-4-endione

4-androstenedione(biological method)4-AD

7-Oxo-Dehydroepiandrosterone(7-OXO-DHEA)

Androst-4-ene-3,17-dione (Androsten

Androstenedione,HPLC≥98%

Androstenedione standard solution, 100ppm