3-[(Benzyloxycarbonyl)amino]propionaldehyde

Product Name: 3-[(Benzyloxycarbonyl)amino]propionaldehyde
CAS No.: 65564-05-8
Chemical Name: 3-[(Benzyloxycarbonyl)amino]propionaldehyde
Synonyms: Z-Beta-Ala-al;N-CBZ-3-AMinopropanal;Benzyl 3-oxopropylcarbaMate;(3-Oxo-propyl)-carbamic acid benzyl ester;3-(Cbz-amino)propanal;N-Cbz-3-oxopropanamine;Benzyl N-(3-oxopropyl)carbamate;3-Aminopropanal, N-CBZ protected;3-Aminopropanal, N-CBZ protected 97%;Phenylmethyl N-(3-oxopropyl)carbamate
CBNumber: CB8366386
Molecular Formula: C11H13NO3
Formula Weight: 207.23
MOL File: 65564-05-8.mol

More

Less

3-[(Benzyloxycarbonyl)amino]propionaldehyde Property

Melting point:: 52-57 °C (lit.)
Boiling point:: 370.1±35.0 °C(Predicted)
Density: 1.142±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
form: Crystalline Powder
pka: 12.08±0.46(Predicted)
color: White to yellow
InChI: InChI=1S/C11H13NO3/c13-8-4-7-12-11(14)15-9-10-5-2-1-3-6-10/h1-3,5-6,8H,4,7,9H2,(H,12,14)
InChIKey: PQMOZOQTXKMYSK-UHFFFAOYSA-N
SMILES: C(OCC1=CC=CC=C1)(=O)NCCC=O
CAS DataBase Reference: 65564-05-8(CAS DataBase Reference)

More

Less

Safety

Hazard Codes: Xi
WGK Germany: 3
HS Code: 29223900

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 592951
Product name: 3-[(Benzyloxycarbonyl)amino]propionaldehyde
Purity: 95%
Packaging: 1g
Price: $109
Updated: 2025/07/31

TCI Chemical

Product number: P3040
Product name: Benzyl (3-Oxopropyl)carbamate
Packaging: 1G
Price: $138
Updated: 2025/07/31

TRC

Product number: B286890
Product name: 3-(Benzyloxycarbonylamino)propionaldehyde
Packaging: 5g
Price: $385
Updated: 2021/12/16

TRC

Product number: B286890
Product name: 3-(Benzyloxycarbonylamino)propionaldehyde
Packaging: 50g
Price: $1650
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB144324
Product name: Benzyl (3-oxopropyl)carbamate
Packaging: 5G
Price: $320
Updated: 2021/12/16

More

Less

3-[(Benzyloxycarbonyl)amino]propionaldehyde Chemical Properties,Usage,Production

Chemical Properties

White to yellow crystalline powder

Uses

3-(Benzyloxycarbonylamino)propionaldehyde is used as a reagent in the synthesis of Tuberactinomycin N, a peptide antibiotic that is used as an anti-tuberculotic drug. 3-(Benzyloxycarbonylamino)propionaldehyde is also used as a reagent to prepare L-epicapreomycidine, a guanidino amino acid that is naturally found in hydrolyzates of protease inhibitors.

Synthesis

34637-22-4

65564-05-8

The general procedure for the synthesis of N-benzyloxycarbonyl-3-aminopropanal from 3-(benzyloxycarbonylamino)-1-propanol was as follows: PCC (8.75 g, 40.6 mmol, 1.7 eq.) and Celite? (9 g) were stirred in dichloromethane (50 mL) for 5 min, followed by the addition of 3-(benzyloxycarbonylamino)-1-propanol (5.0 g, 24 mmol) dissolved in dichloromethane (30 mL). propanol (5.0 g, 24 mmol). After 4 hours of reaction, the reaction mixture was diluted with ether (100 mL) and filtered through a short pad of silica gel and Celite?filter. The residual solid was suspended in dichloromethane (25 mL) and precipitated with ether (50 mL) to pass the mixture through the same filter pad. After this process was repeated three times, the filtrate was evaporated under reduced pressure to give a yellow oil (5.0 g). Purification by column chromatography (petroleum ether solution of 40% ethyl acetate) afforded N-benzyloxycarbonyl-3-aminopropionaldehyde as a colorless viscous oil (3.0 g, 14.5 mmol) in 60% yield. rf value of 0.4 (petroleum ether solution of 50% ethyl acetate, PMA color developed); 1H NMR (CDCl3) δ: 2.75 (2H, t, J=5.7Hz. CH2), 3.49 (2H, apparent q, J=6.0 Hz, CH2), 5.09 (2H, s, CH2), 5.15 (1H, br s, NH), 7.30-7.39 (5H, m, Ar), 9.81 (1H, s, CHO); 13C NMR (CDCl3) δ: 34.6, 44.2, 66.9, 128.2 , 128.3, 128.7, 136.5, 165.4, 201.3; IR (neat) νmax: 3445, 1704, 1645 cm-1.

References

[1] Tetrahedron Letters, 2001, vol. 42, # 2, p. 183 - 185
[2] European Journal of Organic Chemistry, 2012, # 17, p. 3270 - 3277
[3] Tetrahedron, 1997, vol. 53, # 37, p. 12391 - 12404
[4] Tetrahedron Letters, 1987, vol. 28, # 33, p. 3827 - 3830
[5] Synlett, 2017, vol. 28, # 13, p. 1554 - 1557

3-[(Benzyloxycarbonyl)amino]propionaldehyde Preparation Products And Raw materials

Raw materials

Hydrazinium hydroxide solution N-Aminoethylpiperazine 3-Chloropropionaldehyde diethylacetal Dichloromethane Benzyl chloroformate Potassium phthalimide

Preparation Products

More

Less

3-[(Benzyloxycarbonyl)amino]propionaldehyde Suppliers

China 114 Germany 1 India 4 Switzerland 1 United Kingdom 6 United States 18 Global 144

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 42446
Advantage: 60

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Beijing Ouhe Technology Co., Ltd

Tel: 010-010-82967028 13522913783
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 12000
Advantage: 60

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14101
Advantage: 59

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Sinopharm Chemical Reagent Co,Ltd.

Tel: 86-21-63210123
Fax: 86-21-63290778 86-21-63218885
Email: sj_scrc@sinopharm.com
Country: China
ProdList: 9815
Advantage: 79

Shanghai Sunway Pharmaceutical Technology Co., Ltd

Tel: 18270980682
Fax: 021 51613951
Email: mlcheng@sunwaypharm.cn
Country: China
ProdList: 8669
Advantage: 57

More

Less

View Lastest Price from 3-[(Benzyloxycarbonyl)amino]propionaldehyde manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 3-[(Benzyloxycarbonyl)amino]propionaldehyde 65564-05-8
Price: US $0.00-0.00/g
Min. Order: 10mg
Purity: 99%HPLC
Supply Ability: 2000tons
Release date: 2020-01-15

Zhuozhou Wenxi import and Export Co., Ltd

Product: 3-[(Benzyloxycarbonyl)amino]propionaldehyde 65564-05-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-11

Zhuozhou Wenxi import and Export Co., Ltd

Product: 3-[(Benzyloxycarbonyl)amino]propionaldehyde 65564-05-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

65564-05-8, 3-[(Benzyloxycarbonyl)amino]propionaldehydeRelated Search:

ALTRENOGEST Trimethoprim N-Carbobenzyloxyglycine Propionaldehyde Phenylpropyl aldehyde Glycine Tris(hydroxymethyl)aminomethane 2-Aminobenzylchloride Carbobenzyloxy-beta-alanine CBZ-ASP(OBZL)-OBZL N-CARBOBENZOXY-DL-ASPARTIC ACID N-Cbz-L-Aspartic acid 4-benzyl ester N-Benzyloxycarbonyl-L-asparagine N-Carbobenzyloxy-L-aspartic acid Z-ASP(OTBU)-OH DCHA Z-ASN-ONP Z-ASP-OBZL N-Cbz-L-Aspartic acid 4-tert-butyl ester

3-[(Benzyloxycarbonyl)aMino]propionaldehyde 95%

(3-Oxo-propyl)-carbamic acid benzyl ester

3-[(BENZYLOXYCARBONYL)AMINO]PROPIONALDEHYDE

3-[(BENZYLOXYCARBONYL)AMINO]-1-PROPANAL

3-[(Carbobenzyloxy)amino]propionaldehyde

Benzyl N-(3-oxopropyl)carbamate

N-Phenylmethoxycarbonyl-3-aminopropanol

N-Phenylmethoxycarbonyl-3-Aminopropanal

3-Aminopropanal, N-CBZ protected 97%

N-(3-oxopropyl)carbamic acid (phenylmethyl) ester

3-[(Benzyloxycarbonyl)amino]-1-propanal ,95%

3-[(Benzyloxycarbonyl)amino]propionaldehyde,3-[(Benzyloxycarbonyl)amino]-1-propanal, 3-[(Carbobenzyloxy)amino]propionaldehyde

3-((BENZYLOXYCARBONYL)AMINO)-1-PROPANOL&

3-[(Benzyloxycarbonyl)amino]propionaldehyde, Benzyl (3-oxopropyl)carbamate

3-Aminopropanal, N-CBZ protected

3-[(Benzyloxycarbonyl)amino]-1-propanal, 3-[(Carbobenzyloxy)amino]propionaldehyde

3-Hydroxypropyl(benzyloxycarbonyl)amine

3-Hydroxypropylcarbamic acid benzyl ester

3-[(Benzyloxycarbonyl)amino]propionaldehyde,95%

N-CBZ-3-AMinopropanal

Benzyl 3-oxopropylcarbaMate

Carbamic acid, N-(3-oxopropyl)-, phenylmethyl ester

Z-Beta-Ala-al

3-(Cbz-amino)propanal

N-Cbz-3-oxopropanamine

Phenylmethyl N-(3-oxopropyl)carbamate

65564-05-8

C6H5CH2O2CNHCH2CH2CHO

Organic Building Blocks

Building Blocks

Aldehydes

Carbonyl Compounds

C10 to C21