ChemicalBook > CAS DataBase List > 2-CHLORO-3-METHOXYPYRAZINE

2-CHLORO-3-METHOXYPYRAZINE

Product Name
2-CHLORO-3-METHOXYPYRAZINE
CAS No.
40155-28-0
Chemical Name
2-CHLORO-3-METHOXYPYRAZINE
Synonyms
2-BROMOTHIAZOL-4-A...;2-CHLORO-3-METHOXYPYRAZINE;2-Chloro-3-Methoxy-pyrazin;Pyrazine, 2-chloro-3-methoxy-;2-Chloro-3-methoxy-1,4-diazine;2-CHLORO-3-METHOXY PYRAZINE,98+%
CBNumber
CB8368214
Molecular Formula
C5H5ClN2O
Formula Weight
144.56
MOL File
40155-28-0.mol
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2-CHLORO-3-METHOXYPYRAZINE Property

Melting point:
31-32 °C
Boiling point:
180.3±35.0 °C(Predicted)
Density 
1.292±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
-1.48±0.10(Predicted)
Appearance
White to off-white Solid
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Safety

Hazard Codes 
Xn
Risk Statements 
22
HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC
Product number
C596508
Product name
2-Chloro-3-methoxypyrazine
Packaging
10mg
Price
$45
Updated
2021/12/16
Matrix Scientific
Product number
069158
Product name
2-Chloro-3-methoxypyrazine
Purity
95%
Packaging
1g
Price
$54
Updated
2021/12/16
Apolloscientific
Product number
OR61101
Product name
2-Chloro-3-methoxypyrazine
Packaging
250mg
Price
$22
Updated
2021/12/16
SynQuest Laboratories
Product number
4H07-5-Z1
Product name
2-Chloro-3-methoxypyrazine
Packaging
250mg
Price
$24
Updated
2021/12/16
Apolloscientific
Product number
OR61101
Product name
2-Chloro-3-methoxypyrazine
Packaging
1g
Price
$40
Updated
2021/12/16
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2-CHLORO-3-METHOXYPYRAZINE Chemical Properties,Usage,Production

Synthesis

23902-69-4

33332-30-8

40155-28-0

General procedure for the synthesis of 2-chloro-6-methoxypiperazine and 2-chloro-3-methoxypyrazine from 2-methoxypyrazine-4-oxide (CAS: 23902-69-4): 0.98 g (0.0078 mol) of 2-methoxypyrazine-4-oxide (Example P6) was mixed with 4 mL of phosphoryl chloride and heated to reflux and stirred for 2 hours. Prior to the start of the reaction, 1.25 mL (0.0078 mol) of N,N-diethylaniline was slowly added via syringe. After completion of the reaction, the solution was cooled to 20 °C and slowly poured into ice water. After adjusting the pH of the mixture to 9 with 30% aqueous sodium hydroxide, it was extracted four times with 10 mL of chloroform. The organic phases were combined, washed sequentially with 3N hydrochloric acid and saturated sodium chloride solution, and dried over anhydrous sodium sulfate. Separation by silica gel column chromatography (eluent: ethyl acetate/isohexane, 1:8) afforded the target product 2-chloro-3-methoxypyrazine and its isomer 2-chloro-6-methoxypyrazine. 2-chloro-3-methoxypyrazine was obtained in a yield of 0.29 g (25% of the theoretical value) with 1H NMR (300 MHz, CDCl3) δ: 8.143 ppm (s, 1H), 8.131 ppm (s, 1H), 3.988 ppm (s, 3H). The yield of the isomer 2-chloro-6-methoxypyrazine was 0.38 g (33% of the theoretical value), 1H NMR (300 MHz, CDCl3) δ: 8.031 ppm (d, J = 2.7 Hz, 1H), 7.937 ppm (d, J = 2.7 Hz, 1H), 4.057 ppm (s, 3H).

References

[1] Patent: WO2003/87067, 2003, A1. Location in patent: Page/Page column 39

2-CHLORO-3-METHOXYPYRAZINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-CHLORO-3-METHOXYPYRAZINE Suppliers

China 106 Germany 1 India 1 Ukraine 1 United Kingdom 4 United States 23 Global 136
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View Lastest Price from 2-CHLORO-3-METHOXYPYRAZINE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
2-Chloro-3-methoxypyrazine 40155-28-0
Price
US $2.20-8.80/kg
Min. Order
1kg
Purity
99%min
Supply Ability
1000kg
Release date
2025-09-09
Shaanxi Dideu Medichem Co. Ltd
Product
2-CHLORO-3-METHOXYPYRAZINE 40155-28-0
Price
US $1.00-100.00/KG
Min. Order
1KG
Purity
95%
Supply Ability
300KG
Release date
2024-08-16
JINING XINHE CHEMICAL CO., LTD
Product
2-CHLORO-3-METHOXYPYRAZINE 40155-28-0
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10ton
Release date
2024-07-22

40155-28-0, 2-CHLORO-3-METHOXYPYRAZINERelated Search:

Pyrazine 3-CHLORO-5-METHOXYPYRAZINE-2-CARBALDEHYDE METHYL 3-AMINO-6-CHLORO-5-METHOXYPYRAZINE-2-CARBOXYLATE 2-Chloro-5-methoxypyrazine 2-CHLORO-6-METHOXYPYRAZINE METHYL 6-CHLORO-3-METHOXYPYRAZINE-2-CARBOXYLATE 5-CHLORO-3-METHOXYPYRAZINE-2-CARBALDEHYDE 2-CHLORO-3-METHOXYQUINOXALINE 3-Chloro-5-(dichloromethyl)-2-methoxy-pyrazine 2-CHLORO-3-METHOXYPYRAZINE

  • 2-Chloro-3-methoxy-1,4-diazine
  • 2-Chloro-3-Methoxy-pyrazin
  • 2-CHLORO-3-METHOXYPYRAZINE
  • 2-CHLORO-3-METHOXY PYRAZINE,98+%
  • 2-BROMOTHIAZOL-4-A...
  • Pyrazine, 2-chloro-3-methoxy-
  • 40155-28-0
  • alkyl chloride