2-PHENYL-PYRIDIN-4-YLAMINE
- Product Name
- 2-PHENYL-PYRIDIN-4-YLAMINE
- CAS No.
- 21203-86-1
- Chemical Name
- 2-PHENYL-PYRIDIN-4-YLAMINE
- Synonyms
- 2-PPA;2-Phenylpyridin-4-aMine;4-AMINO-2-PHENYLPYRIDINE;4-Pyridinamine, 2-phenyl-;2-PHENYL-PYRIDIN-4-YLAMINE;Pyridine, 4-amino-2-phenyl-
- CBNumber
- CB8370897
- Molecular Formula
- C11H10N2
- Formula Weight
- 170.21
- MOL File
- 21203-86-1.mol
2-PHENYL-PYRIDIN-4-YLAMINE Property
- Boiling point:
- 384.2±30.0 °C(Predicted)
- Density
- 1.133±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 8.22±0.10(Predicted)
- form
- solid
- color
- Pale yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A615980
- Product name
- 4-Amino-2-phenylpyridine
- Packaging
- 50mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- CS-D1566
- Product name
- 2-Phenylpyridin-4-amine
- Purity
- >98.0%
- Packaging
- 250mg
- Price
- $51
- Updated
- 2021/12/16
- Product number
- CS-D1566
- Product name
- 2-Phenylpyridin-4-amine
- Purity
- >98.0%
- Packaging
- 1g
- Price
- $66
- Updated
- 2021/12/16
- Product number
- 3H30-1-KX
- Product name
- 4-Amino-2-phenylpyridine
- Purity
- 97%
- Packaging
- 1g
- Price
- $228
- Updated
- 2021/12/16
- Product number
- 076480
- Product name
- 4-Amino-2-phenylpyridine
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $231
- Updated
- 2021/12/16
2-PHENYL-PYRIDIN-4-YLAMINE Chemical Properties,Usage,Production
Uses
2-PPA is a selective inhibitor of TMEM175 (IC50=32 μM) with activity in modulating lysosomal function. Acute inhibition of TMEM175 by 2-PPA increases lysosomal macromolecular catabolism, thereby accelerating macrophage and other digestive processes. 2-PPA can be used in the study of Parkinson's disease[1].
Synthesis
14432-12-3
98-80-6
21203-86-1
a) Synthesis of 2-phenyl-pyridin-4-ylamine: To a stirred solution of 16.0 g (124 mmol) of 2-chloro-4-aminopyridine dissolved in 200 ml of toluene, 18.2 g (149 mmol) of phenylboronic acid, 7.19 g (6.22 mmol) of tetrakis(triphenylphosphine)palladium(0), and 130 ml (260 mmol) of 2M sodium carbonate were added in turn. aqueous solution. The reaction mixture was heated to reflux at 100 °C for 16 h and subsequently cooled to room temperature. The reaction solution was extracted three times with ethyl acetate and the organic phases were combined. The organic phase was washed three times with 200 ml of 1 M hydrochloric acid aqueous solution. The acidic and aqueous phases were combined, adjusted to alkaline with 5 M aqueous sodium hydroxide and extracted three times with dichloromethane. The organic extracts were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by fast column chromatography (eluent: acetone) and subsequently ground in hexane containing a small amount of ether to give 18.5 g (87% yield) of 2-phenyl-pyridin-4-ylamine as a white solid.ES-MS m/e (relative abundance): 171 ([M+H]+, 100).
References
[1] SeCheol, et al. "Discovery of Selective Inhibitors for the Lysosomal Parkinson’s Disease Channel TMEM175." Journal of the American Chemical Society (2024). DOI:10.1021/jacs.4c05623
2-PHENYL-PYRIDIN-4-YLAMINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-PHENYL-PYRIDIN-4-YLAMINE manufacturers
- Product
- 2-PHENYL-PYRIDIN-4-YLAMINE 21203-86-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95%
- Supply Ability
- 500KG
- Release date
- 2018-08-19