ChemicalBook > CAS DataBase List > SKF 83959 HYDROBROMIDE

SKF 83959 HYDROBROMIDE

Product Name
SKF 83959 HYDROBROMIDE
CAS No.
80751-85-5
Chemical Name
SKF 83959 HYDROBROMIDE
Synonyms
SKF 83959 hydrobromi;SKF 83959 HYDROBROMIDE;SKF83959, 10 mM in DMSO;N-methyl-6-chloro-1-(3-methylphenyl)-2,3,4,5-tetrahydro-3-benzazepine-7,8-diol;6-Chloro-2,3,4,5-tetrahydro-3-methyl-1-(3-methylphenyl)-1H-3-benzazepine-7,8-diol;1H-3-Benzazepine-7,8-diol, 6-chloro-2,3,4,5-tetrahydro-3-methyl-1-(3-methylphenyl)-;6-CHLORO-7,8-DIHYDROXY-3-METHYL-1-(3-METHYLPHENYL)-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE;6-CHLORO-2,3,4,5-TETRAHYDRO-3-METHYL-1-(3-METHYLPHENYL)-1H-3-BENZAZEPINE-7,8-DIOL HYDROBROMIDE;6-Chloro-7,8-dihydroxy-3-methyl-1-(3-methylphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide
CBNumber
CB8377119
Molecular Formula
C18H20ClNO2
Formula Weight
317.81
MOL File
80751-85-5.mol
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SKF 83959 HYDROBROMIDE Property

storage temp. 
Store at RT
solubility 
DMSO: 26 mg/mL, soluble
form 
solid
color 
white
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S2816
Product name
SKF-83959 hydrobromide
Purity
≥98% (HPLC), solid
Packaging
5mg
Price
$228.95
Updated
2025/07/31
Sigma-Aldrich
Product number
S2816
Product name
SKF-83959 hydrobromide
Purity
≥98% (HPLC), solid
Packaging
25mg
Price
$868
Updated
2022/05/15
Tocris
Product number
2074
Product name
SKF-83959 hydrobromide
Purity
≥98%(HPLC)
Packaging
50
Price
$870
Updated
2021/12/16
Tocris
Product number
2074
Product name
SKF-83959 hydrobromide
Purity
≥98%(HPLC)
Packaging
10
Price
$208
Updated
2021/12/16
Usbiological
Product number
256682
Product name
SKF 83959 hydrobromide
Packaging
10mg
Price
$466
Updated
2021/12/16
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SKF 83959 HYDROBROMIDE Chemical Properties,Usage,Production

Uses

SKF-83959 was used in dopamine signaling studies on eye blinking in monkeys and on phosphorylation of CaMKIIα in mice.

Definition

ChEBI: A benzazepine that is 2,3,4,5-tetrahydro-3-benzazepine bearing a 3-methylphenyl substituent at position 1, a methyl substituent at position 3, a chloro substituent at position 6 and two hydroxy substituents at positions 7 and 8. Dopamine D1-like receptor p rtial agonist (Ki values are 1.18, 7.56, 920 and 399 nM for rat D1, D5, D2 and D3 receptors respectively). May act as an antagonist in vivo, producing anti-Parkinsonian effects and antagonising the behavioral effects of cocaine.

Biological Activity

Dopamine D 1 -like receptor partial agonist (K i values are 1.18, 7.56, 920 and 399 nM for rat D 1 , D 5 , D 2 and D 3 receptors respectively). May act as an antagonist in vivo , producing antiparkinsonian effects and antagonizing the behavioral effects of cocaine.

in vivo

SKF83959 (0.5 and 1 mg/kg; i.p.; 1 hour) reverses the scopolamine-induced cognitive impairments in the passive avoidance task and Y-Maze test[1].
SKF83959 (1 mg/kg; i.p.; 30 minutes) induced memory enhancing effects are prevented by brain-derived neurotrophic factor system blockade[1].
SKF83959 has anti-amnesic activities and restores the scopolamine-decreased BDNF signaling pathway in the hippocampus in mice[1].

Animal Model:Male ICR male mice (8 weeks)[1]
Dosage:0.5 and 1 mg/kg
Administration:I.p.; 1 hour
Result:Reversed the scopolamine-induced cognitive impairments in the passive avoidance task and Y-Maze test.
Animal Model:Male ICR male mice (8 weeks)[1]
Dosage:1 mg/kg
Administration:I.p.; 30 minutes
Result:The memory enhancing effects were prevented by BDNF system blockade.

IC 50

D1 Receptor: 1.18 nM (Ki); Sigma 1 Receptor; D5 Receptor: 7.56 nM (Ki); D2 Receptor: 920 nM (Ki); D3 Receptor: 399 nM (Ki)

SKF 83959 HYDROBROMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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SKF 83959 HYDROBROMIDE Suppliers

CHINA 12 Germany 2 Switzerland 1 United Kingdom 1 United States 4 Global 20
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15838
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Shanghai Universal Biotech Co.,Ltd
Tel
15921930842 15921930842
Email
yh-wang@univ-bio.com
Country
China
ProdList
25004
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58
Nantong QuanYi Biotechnology Co., Ltd
Tel
0513-66337626 18051384581
Email
sales@chemhifuture.com
Country
China
ProdList
5929
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Shanghai Yifei Biotechnology Co. , Ltd.
Tel
021-65675885 18964387627
Email
customer_service@efebio.com
Country
China
ProdList
11973
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58
TargetMol Chemicals Inc.
Tel
15002134094
Email
marketing@targetmol.cn
Country
China
ProdList
29357
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58
Sangon Biotech (Shanghai) Co.,Ltd.
Tel
400-821-026
Email
Sales@sangon.com
Country
China
ProdList
6710
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58
Merck KGaA
Tel
21-20338288
Email
ordercn@merckgroup.com
Country
China
ProdList
6394
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58
Guangzhou Ruifeng Biotechnology Co., Ltd.
Tel
14715141318
Country
CHINA
ProdList
181
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58
Guangzhou Qiansheng Biotechnology Co., Ltd.
Tel
14748676110
Country
CHINA
ProdList
112
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58
Neobioscience Co., Ltd.
Tel
--
Fax
--
Email
info@neobioscience.com
Country
CHINA
ProdList
6207
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58
Absin Bioscience Inc.
Tel
--
Fax
--
Email
chenjw@absin.cn
Country
CHINA
ProdList
6208
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58
Proteintech China
Tel
--
Fax
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Email
Proteintech-CN@ptglab.com
Country
CHINA
ProdList
6290
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58

80751-85-5, SKF 83959 HYDROBROMIDERelated Search:

6-CHLORO-2,3,4,5-TETRAHYDRO-1-(3-METHYLPHENYL)-3-(2-PROPENYL)-1H-3-BENZAZEPINE-7,8-DIOL HYDROBROMIDE 2-phenyl-4-azabicyclo[5.4.0]undeca-7,9,11-triene-9,10-diol SKF 83959 HYDROBROMIDE (+/-)-SKF-38393 HYDROCHLORIDE (+/-)-6-CHLORO-7,8-DIHYDROXY-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROBROMIDE

  • 6-CHLORO-2,3,4,5-TETRAHYDRO-3-METHYL-1-(3-METHYLPHENYL)-1H-3-BENZAZEPINE-7,8-DIOL HYDROBROMIDE
  • 6-CHLORO-7,8-DIHYDROXY-3-METHYL-1-(3-METHYLPHENYL)-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE
  • SKF 83959 HYDROBROMIDE
  • 6-Chloro-2,3,4,5-tetrahydro-3-methyl-1-(3-methylphenyl)-1H-3-benzazepine-7,8-diol
  • 6-Chloro-7,8-dihydroxy-3-methyl-1-(3-methylphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide
  • N-methyl-6-chloro-1-(3-methylphenyl)-2,3,4,5-tetrahydro-3-benzazepine-7,8-diol
  • 1H-3-Benzazepine-7,8-diol, 6-chloro-2,3,4,5-tetrahydro-3-methyl-1-(3-methylphenyl)-
  • SKF 83959 hydrobromi
  • SKF83959, 10 mM in DMSO
  • 80751-85-5
  • C18H20ClNO2HBr
  • C18H20NClO2HBr
  • Dopamine receptor