Methyl L-tyrosinate hydrochloride

Product Name: Methyl L-tyrosinate hydrochloride
CAS No.: 3417-91-2
Chemical Name: Methyl L-tyrosinate hydrochloride
Synonyms: Tyr-OmeHCl;Tyr.OCH3.HCL;H-TYR-OME HCL;H-Tyr-OMe·HCI;L-Tyr-OMe.HCL;H-L-TYR-OME HCL;TYROSINE-OME HCL;METHYL TYROSINATE HCL;H-Tyr-Ome x HCl ,≥99%;Methyl L-tyrosinate HCl
CBNumber: CB8377199
Molecular Formula: C10H14ClNO3
Formula Weight: 231.68
MOL File: 3417-91-2.mol

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Methyl L-tyrosinate hydrochloride Property

Melting point:: 192 °C (dec.)(lit.)
alpha: 74 º (c=3,1N pyridine)
refractive index: 13 ° (C=2, MeOH)
storage temp.: 2-8°C
Water Solubility: very faint turbidity in Water
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form: powder to crystal
color: White to Almost white
optical activity: [α]25/D +74.0°, c = 3 in pyridine
Sensitive: Hygroscopic
BRN: 3917353
InChI: InChI=1/C10H13NO3.ClH/c1-14-10(13)9(11)6-7-2-4-8(12)5-3-7;/h2-5,9,12H,6,11H2,1H3;1H/t9-;/s3
InChIKey: VXYFARNRGZWHTJ-OVMXBOEKNA-N
SMILES: C1(C=CC(O)=CC=1)C[C@H](N)C(=O)OC.Cl |&1:8,r|
CAS DataBase Reference: 3417-91-2(CAS DataBase Reference)
EPA Substance Registry System: L-Tyrosine, methyl ester, hydrochloride (3417-91-2)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
TSCA: Yes
HazardClass: IRRITANT
HS Code: 29225000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 850489
Product name: L-Tyrosine methyl ester hydrochloride
Packaging: 25g
Price: $92.1
Updated: 2025/07/31

TCI Chemical

Product number: T1108
Product name: L-Tyrosine Methyl Ester Hydrochloride
Purity: >98.0%(T)
Packaging: 5g
Price: $21
Updated: 2025/07/31

TCI Chemical

Product number: T1108
Product name: L-Tyrosine Methyl Ester Hydrochloride
Purity: >98.0%(T)
Packaging: 25g
Price: $55
Updated: 2025/07/31

TRC

Product number: T966378
Product name: L-Tyrosine methyl ester hydrochloride
Packaging: 500mg
Price: $75
Updated: 2021/12/16

Usbiological

Product number: 239466
Product name: L-Tyrosine methyl ester hydrochloride
Packaging: 25g
Price: $170
Updated: 2021/12/16

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Methyl L-tyrosinate hydrochloride Chemical Properties,Usage,Production

Chemical Properties

Crystalline

Uses

peptide synthesis

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

67-56-1

60-18-4

3417-91-2

1. Acetyl chloride (21.32 mL, 300 mmol) was slowly added dropwise to 200 mL of anhydrous methanol under ice bath conditions with stirring for 30 minutes. 2. L-tyrosine (18.1 g, 100 mmol) was added to the above solution, followed by transferring the reaction mixture to an oil bath and heating to reflux for 4 hours. 3. After completion of the reaction, the solvent was removed by distillation under reduced pressure. Appropriate amount of acetone was added to the residue and filtered to obtain white powdery L-tyrosine methyl ester hydrochloride (22.78 g, 99% yield). 4. Di-tert-butyl dicarbonate (11.34 g, 52 mmol) was dissolved in 50 mL of 1,4-dioxane and slowly added to 160 mL of mixed solvent (1,4-dioxane-H2O = 1:1) containing L-tyrosine methyl ester hydrochloride (9.26 g, 40 mmol) and K2CO3 (8.28 g, 60 mmol). 5. After stirring the reaction mixture at room temperature overnight, the solvent was removed by concentration under reduced pressure. EtOAc was added for extraction and the EtOAc layer was washed sequentially with 1N citric acid, saturated NaHCO3 solution and brine. 6. The organic layer was dried over anhydrous MgSO4 and concentrated under reduced pressure to give compound 2 in white powder form, which can be used in subsequent steps without further purification.

References

[1] Synthetic Communications, 1992, vol. 22, # 7, p. 979 - 985
[2] Tetrahedron, 2001, vol. 57, # 39, p. 8313 - 8322
[3] Chemistry - A European Journal, 2011, vol. 17, # 22, p. 6206 - 6213
[4] European Journal of Medicinal Chemistry, 2018, vol. 145, p. 649 - 660
[5] Heterocycles, 2002, vol. 56, # 1-2, p. 157 - 170

Methyl L-tyrosinate hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Methyl L-tyrosinate hydrochloride Suppliers

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View Lastest Price from Methyl L-tyrosinate hydrochloride manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: Methyl L-tyrosinate hydrochloride 3417-91-2
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100 mt
Release date: 2024-11-13

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: L-Tyr-Ome.HCl 3417-91-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T+
Release date: 2024-04-08

Hebei Zhuanglai Chemical Trading Co Ltd

Product: Methyl L-tyrosinate hydrochloride 3417-91-2
Price: US $60.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 tons
Release date: 2024-11-22

3417-91-2, Methyl L-tyrosinate hydrochlorideRelated Search:

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Methyl L-Tyrosinate Hydrochloride,99%e.e.

L-Methyltyrosinate hydrochloride for synthesis

TYROSINE-OME HCL

(S)-Methyl 2-aMino-3-(4-hydroxyphenyl)propanoate hydrochloride

H-TYR-OME HCL

H-L-TYR-OME HCL

METHYL L-TYROSINATE HYDROCHLORIDE

METHYL TYROSINATE HCL

L -TYROSINE METHYL ESTER HYDROCHLORIDE 98%

L-TYROSINE METHYL ESTER HCL

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L-TYROSINE METHYL ESTER HYDROCHLORIDE

L-TYROSINE METHYL ESTER HYDROCHLORIDE SALT

L-METHYLTYROSINATE HYDROCHLORIDE

H-Tyr-OMe·HCI

L-Tyrosine Methylester HLC

Tyrosine, methyl ester, HCl

Methyl (2S)-2-amino-3-(4-hydroxyphenyl)propanoate hydrochloride

Tyrosine methyl·hydrochloric acid

L-Tyrosine methyl ester hydrochloride,99%

L-Tyr-OMe.HCL

H-Tyr-Ome x HCl ,≥99%

Tyr-OmeHCl

L-Tyrosinemethylesterhydrochloride,98+%

L-TYROSINEMETHYLESTERHYDROCHLROIDE

L-TYROSINE MTHYLESTER HYDROCHLORIDE

(S)-2-Amino-3-(4-hydroxy-phenyl)-propionic acidmethyl ester hydrochloride

2-amino-3-(4-hydroxyphenyl)propanoic acid methyl ester chloride

Tyr.OCH3.HCL

Methyl L-tyrosinate HCl

Methyl L-tyrosinate hydrochloride, Methyl (2S)-2-amino-3-(4-hydroxyphenyl)propanoate hydrochloride, H-Tyr-OMe.HCl

L-Tyrosine methyl ester hydrochloride, 98.5%

Mehtyl L-tyrosinate hydrochloride

METHYL L-TYROSINATE HYDROCHLORIDE 3417-91-2

Methyl L-tyrosinate hydrochloride USP/EP/BP

[(2S)-3-(4-hydroxyphenyl)-1-methoxy-1-oxopropan-2-yl]azanium

TIANFUCHEM--3417-91-2---Methyl L-tyrosinate hydrochloride

L-Tyrosine, methyl ester, hydrochloride (9CI)

<sc>L</sc>-Tyrosine methyl ester hydrochloride

3417-91-2

C1013O3NxHCl

HOC6H4CH2CHNH2COOCH3HCl

C10H13NO3xHCl

Amino Acid Derivatives

Amino Acid Methyl Esters

Amino Acids (C-Protected)

Protected & Labeled Amino Acids

Tyrosine

Specialty Synthesis

Peptide Synthesis

Tyrosine [Tyr, Y]

Amino Acids and Derivatives

Amino Acids

Amino Acid Methyl Esters

Amino Acids (C-Protected)

Biochemistry

Amino hydrochloride