ChemicalBook > CAS DataBase List > Methyl L-tyrosinate hydrochloride

Methyl L-tyrosinate hydrochloride

Product Name
Methyl L-tyrosinate hydrochloride
CAS No.
3417-91-2
Chemical Name
Methyl L-tyrosinate hydrochloride
Synonyms
Tyr-OmeHCl;Tyr.OCH3.HCL;H-TYR-OME HCL;H-Tyr-OMe·HCI;L-Tyr-OMe.HCL;H-L-TYR-OME HCL;TYROSINE-OME HCL;METHYL TYROSINATE HCL;H-Tyr-Ome x HCl ,≥99%;Methyl L-tyrosinate HCl
CBNumber
CB8377199
Molecular Formula
C10H14ClNO3
Formula Weight
231.68
MOL File
3417-91-2.mol
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Methyl L-tyrosinate hydrochloride Property

Melting point:
192 °C (dec.)(lit.)
alpha 
74 º (c=3,1N pyridine)
refractive index 
13 ° (C=2, MeOH)
storage temp. 
2-8°C
Water Solubility 
very faint turbidity in Water
solubility 
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form 
powder to crystal
color 
White to Almost white
optical activity
[α]25/D +74.0°, c = 3 in pyridine
Sensitive 
Hygroscopic
BRN 
3917353
InChI
InChI=1/C10H13NO3.ClH/c1-14-10(13)9(11)6-7-2-4-8(12)5-3-7;/h2-5,9,12H,6,11H2,1H3;1H/t9-;/s3
InChIKey
VXYFARNRGZWHTJ-OVMXBOEKNA-N
SMILES
C1(C=CC(O)=CC=1)C[C@H](N)C(=O)OC.Cl |&1:8,r|
CAS DataBase Reference
3417-91-2(CAS DataBase Reference)
EPA Substance Registry System
L-Tyrosine, methyl ester, hydrochloride (3417-91-2)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
TSCA 
Yes
HazardClass 
IRRITANT
HS Code 
29225000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
850489
Product name
L-Tyrosine methyl ester hydrochloride
Packaging
25g
Price
$92.1
Updated
2025/07/31
TCI Chemical
Product number
T1108
Product name
L-Tyrosine Methyl Ester Hydrochloride
Purity
>98.0%(T)
Packaging
5g
Price
$21
Updated
2025/07/31
TCI Chemical
Product number
T1108
Product name
L-Tyrosine Methyl Ester Hydrochloride
Purity
>98.0%(T)
Packaging
25g
Price
$55
Updated
2025/07/31
Usbiological
Product number
290841
Product name
L-Tyrosine methyl ester hydrochloride
Packaging
25g
Price
$389
Updated
2021/12/16
TRC
Product number
T966378
Product name
L-Tyrosine methyl ester hydrochloride
Packaging
500mg
Price
$75
Updated
2021/12/16
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Methyl L-tyrosinate hydrochloride Chemical Properties,Usage,Production

Chemical Properties

Crystalline

Uses

peptide synthesis

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

67-56-1

60-18-4

3417-91-2

1. Acetyl chloride (21.32 mL, 300 mmol) was slowly added dropwise to 200 mL of anhydrous methanol under ice bath conditions with stirring for 30 minutes. 2. L-tyrosine (18.1 g, 100 mmol) was added to the above solution, followed by transferring the reaction mixture to an oil bath and heating to reflux for 4 hours. 3. After completion of the reaction, the solvent was removed by distillation under reduced pressure. Appropriate amount of acetone was added to the residue and filtered to obtain white powdery L-tyrosine methyl ester hydrochloride (22.78 g, 99% yield). 4. Di-tert-butyl dicarbonate (11.34 g, 52 mmol) was dissolved in 50 mL of 1,4-dioxane and slowly added to 160 mL of mixed solvent (1,4-dioxane-H2O = 1:1) containing L-tyrosine methyl ester hydrochloride (9.26 g, 40 mmol) and K2CO3 (8.28 g, 60 mmol). 5. After stirring the reaction mixture at room temperature overnight, the solvent was removed by concentration under reduced pressure. EtOAc was added for extraction and the EtOAc layer was washed sequentially with 1N citric acid, saturated NaHCO3 solution and brine. 6. The organic layer was dried over anhydrous MgSO4 and concentrated under reduced pressure to give compound 2 in white powder form, which can be used in subsequent steps without further purification.

References

[1] Synthetic Communications, 1992, vol. 22, # 7, p. 979 - 985
[2] Tetrahedron, 2001, vol. 57, # 39, p. 8313 - 8322
[3] Chemistry - A European Journal, 2011, vol. 17, # 22, p. 6206 - 6213
[4] European Journal of Medicinal Chemistry, 2018, vol. 145, p. 649 - 660
[5] Heterocycles, 2002, vol. 56, # 1-2, p. 157 - 170

Methyl L-tyrosinate hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Methyl L-tyrosinate hydrochloride manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
Methyl L-tyrosinate hydrochloride 3417-91-2
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100 mt
Release date
2024-11-13
Sichuan HongRi Pharma-Tech Co.,Ltd
Product
L-Tyr-Ome.HCl 3417-91-2
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T+
Release date
2024-04-08
Hebei Zhuanglai Chemical Trading Co Ltd
Product
Methyl L-tyrosinate hydrochloride 3417-91-2
Price
US $60.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 tons
Release date
2024-11-22

3417-91-2, Methyl L-tyrosinate hydrochlorideRelated Search:

Methylparaben Topotecan hydrochloride Bensulfuron methyl L-Tyrosine Kresoxim-methyl Methyl L-tyrosinate L-Alanine methyl ester hydrochloride TYROSINASE Methyl acrylate H-ARG-ARG-LEU-ILE-GLU-ASP-ASN-GLU-TYR-THR-ALA-ARG-GLY-OH Boc-D-Tyr-OH Thiophanate-methyl Methyl H-TYR(TBU)-OTBU HCL L-TYROSINE ETHYL ESTER HYDROCHLORIDE Methyl bromide O-Benzyl-L-tyrosine benzyl ester hydrochloride O-Benzyl-L-tyrosine methyl ester hydrochloride

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  • Amino Acid Derivatives
  • Amino Acid Methyl Esters
  • Amino Acids (C-Protected)
  • Protected & Labeled Amino Acids
  • Tyrosine
  • Specialty Synthesis
  • Peptide Synthesis
  • Tyrosine [Tyr, Y]
  • Amino Acids and Derivatives
  • Amino Acids
  • Amino Acid Methyl Esters
  • Amino Acids (C-Protected)
  • Biochemistry
  • Amino hydrochloride