ChemicalBook > CAS DataBase List > 1,4-DIOXA-SPIRO[4.5]DECAN-8-OL

1,4-DIOXA-SPIRO[4.5]DECAN-8-OL

Product Name
1,4-DIOXA-SPIRO[4.5]DECAN-8-OL
CAS No.
22428-87-1
Chemical Name
1,4-DIOXA-SPIRO[4.5]DECAN-8-OL
Synonyms
4-Dioxaspiro[4.5]decan-8-ol;4,4-Ethylenedioxycyclohexanol.;1,4-DIOXA-SPIRO[4.5]DECAN-8-OL;4,4-(Ethylenebisoxy)cyclohexanol;1,4-Dioxaspiro[4.5]decan-8-ol,98%;4-Hydroxycyclohexanone ethylene acetal;4-HYDROXYCYCLOHEXANONE MONOETHYLENE KETAL;4-Hydroxycyclohexanone ethylene acetal, 90+%;4-Hydroxycyclohexanone ethylene glycol ketal;4-Hydroxycyclohexan-1-one monoethylene ketal
CBNumber
CB8379557
Molecular Formula
C8H14O3
Formula Weight
158.2
MOL File
22428-87-1.mol
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1,4-DIOXA-SPIRO[4.5]DECAN-8-OL Property

Boiling point:
103-104 °C(Press: 0.55 Torr)
Density 
1.17±0.1 g/cm3(Predicted)
refractive index 
1.485-1.487
storage temp. 
Inert atmosphere,2-8°C
pka
15.11±0.20(Predicted)
form 
Viscous Liquid
color 
Clear colorless
InChI
InChI=1S/C8H14O3/c9-7-1-3-8(4-2-7)10-5-6-11-8/h7,9H,1-6H2
InChIKey
HKQTYQDNCKMNHZ-UHFFFAOYSA-N
SMILES
O1C2(CCC(O)CC2)OCC1
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Safety

Hazard Codes 
Xi
Safety Statements 
24/25
HazardClass 
IRRITANT
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
D6215
Product name
1,4-Dioxaspiro[4.5]decan-8-ol
Purity
min. 98.0 %
Packaging
5G
Price
$70
Updated
2025/07/31
TCI Chemical
Product number
D6215
Product name
1,4-Dioxaspiro[4.5]decan-8-ol
Purity
min. 98.0 %
Packaging
25G
Price
$210
Updated
2025/07/31
TRC
Product number
D486285
Product name
1,4-Dioxaspiro[4.5]decan-8-ol
Packaging
1g
Price
$60
Updated
2021/12/16
Matrix Scientific
Product number
020028
Product name
4-Hydroxycyclohexanone monoethylene ketal
Packaging
1g
Price
$10
Updated
2021/12/16
AK Scientific
Product number
W4619
Product name
1,4-Dioxaspiro[4.5]decan-8-ol
Packaging
1g
Price
$14
Updated
2021/12/16
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1,4-DIOXA-SPIRO[4.5]DECAN-8-OL Chemical Properties,Usage,Production

Chemical Properties

clear colorless viscous liquid

Uses

1,4-Dioxaspiro[4.5]decan-8-ol can be used to synthesize pharmaceutical compounds such as diuretics.

Synthesis

4746-97-8

22428-87-1

Step A: Preparation of 4-dioxaspiro[4.5]decan-8-ol 1,4-Cyclohexanedione monoethylene glycol ketal (5.0134 g, 32.10 mmol) was dissolved in methanol (100 mL) and cooled in an ice bath. Sodium borohydride (3.64 g, 96.30 mmol) was added to the solution in batches over 20 min. The reaction mixture was stirred at 0 °C for 30 min, then slowly warmed to room temperature and continued stirring for 1 h. The reaction mixture was then stirred at 0 °C for 1 h. The reaction mixture was then stirred at 0 °C for 1 h. Upon completion of the reaction, 4-hydroxycyclohexanone ethylene glycol acetal (5.56 g, 109% yield) was obtained by a standard post-processing step, the product was a yellow oil and could be used in subsequent reactions without further purification. The structure of the product was confirmed by 1H NMR (400 MHz, chloroform-D): δ 1.47-1.70 (m, 5H), 1.72-1.92 (m, 4H), 3.70-3.83 (m, 1H), 3.85-3.96 (m, 4H).

References

[1] Journal of Medicinal Chemistry, 1992, vol. 35, # 12, p. 2243 - 2247
[2] Journal of the American Chemical Society,
[3] Journal of the American Chemical Society, 2009, vol. 131, p. 251 - 262
[4] Patent: US2009/275574, 2009, A1. Location in patent: Page/Page column 16
[5] Patent: WO2013/30665, 2013, A1. Location in patent: Page/Page column 175; 176

1,4-DIOXA-SPIRO[4.5]DECAN-8-OL Preparation Products And Raw materials

Raw materials

Preparation Products

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1,4-DIOXA-SPIRO[4.5]DECAN-8-OL Suppliers

Belgium 2 China 178 China Hong Kong 1 Germany 2 India 3 Japan 1 Switzerland 1 Ukraine 1 United Kingdom 3 United States 19 Global 211
UkrOrgSynthesis Ltd.
Tel
--
Fax
--
Email
y.barysheva@ukrorgsynth.com
Country
Ukraine
ProdList
6230
Advantage
38
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View Lastest Price from 1,4-DIOXA-SPIRO[4.5]DECAN-8-OL manufacturers

Hebei Yanxi Chemical Co., Ltd.
Product
1,4-DIOXA-SPIRO[4.5]DECAN-8-OL 22428-87-1
Price
US $0.00/kg
Min. Order
1kg
Purity
99.50%
Supply Ability
20tons
Release date
2023-09-14
Career Henan Chemical Co
Product
1,4-DIOXA-SPIRO[4.5]DECAN-8-OL 22428-87-1
Price
US $2.00/KG
Min. Order
1g
Purity
98%min
Supply Ability
ask
Release date
2020-01-08

22428-87-1, 1,4-DIOXA-SPIRO[4.5]DECAN-8-OLRelated Search:

Cyclohexanone 4-HYDROXYCYCLOHEXANONE 8-(4-CHLORO-PHENYL)-1,4-DIOXA-SPIRO[4.5]DECAN-8-OL 1,4-DIOXA-SPIRO[4.5]DECAN-8-OL 8-(4-BROMOPHENYL)-1,4-DIOXASPRIO[4,5]DECAN-8-OL 4-(8-HYDROXY-1,4-DIOXA-SPIRO[4.5]DEC-8-YL)-BENZONITRILE 1,4-DIOXASPIRO[4.5]DECAN-8-YL METHANESULFONATE N-(4-CHLOROPHENYL)-1,4,9-TRIOXA-12-AZADISPIRO[4.2.4.2]TETRADECANE-12-CARBOXAMIDE 8-PHENYL-1,4-DIOXASPIRO[4,5]DECAN-8-OL CHEMPACIFIC 43811 8-(3-HYDROXY-PROPYL)-1,4-DIOXA-SPIRO[4.5]DECAN-8-OL ACETIC ACID 1,4-DIOXA-SPIRO[4.5]DEC-8-YL ESTER 3-(8-HYDROXY-1,4-DIOXA-SPIRO[4,5]DEC-8-YL)-BENZONITRILE AKOS 90421 1,4-Cyclohexanedione bis(ethylene ketal)

  • 4-HYDROXYCYCLOHEXANONE MONOETHYLENE KETAL
  • 1,4-DIOXA-SPIRO[4.5]DECAN-8-OL
  • 4,4-Ethylenedioxycyclohexanol.
  • 4-Hydroxycyclohexanone ethylene acetal, 90+%
  • 4,4-(Ethylenebisoxy)cyclohexanol
  • 1,4-Dioxaspiro[4.5]decan-8-ol,98%
  • 4-Dioxaspiro[4.5]decan-8-ol
  • 4-Hydroxycyclohexanone ethylene acetal
  • 4-Hydroxycyclohexan-1-one monoethylene ketal 98%
  • 1,4-Dioxaspiro[4.5]decan-8-ol (6CI, 8CI, 9CI, ACI)
  • 4-hydroxycyclohexanone ethylene glycol acetal
  • 4-Hydroxycyclohexanone ethylene glycol ketal
  • 4-Hydroxycyclohexan-1-one monoethylene ketal
  • 22428-87-1
  • Miscellaneous