E-4031

Product Name: E-4031
CAS No.: 113559-13-0
Chemical Name: E-4031
Synonyms: E-4031;E4031 diHCl;E-4031 (hydrochloride);E-4031 dihydrochloride, HERG K+ channel blocker;1-(2-(6-methyl-2-pyridyl)ethyl)-4-(4-methylsulfonylaminobenzoyl)piperidined;methanesulfonamide,n-(4-((1-(2-(6-methyl-2-pyridinyl)ethyl)-4-piperidinyl)carb;Inhibitor,anti-arrhythmic,Potassium Channel,E4031,E 4031,KcsA,inhibit,E-4031,hERG;N-(4-(1-(2-(6-METHYLPYRIDIN-2-YL)ETHYL)PIPERIDINE-4-CARBONYL)PHENYL)METHANESULFONAMIDE 2HCL;N-[4-[1-[2-(6-methylpyridin-2-yl)ethyl]piperidine-4-carbonyl]phenyl]methanesulfonamide dihydrochloride;N-[4-[1-[2-(6-Methyl-2-pyridinyl)ethyl]-4-piperidinylcarbonyl]phenyl]methanesulfonamide·2hydrochloric acid
CBNumber: CB8384065
Molecular Formula: C21H33Cl2N3O5S
Formula Weight: 510.47
MOL File: 113559-13-0.mol

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E-4031 Property

storage temp.: -20°C
solubility: H2O: soluble
form: solid
color: off-white
Stability:: Hygroscopic

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: M5060
Product name: E-4031
Purity: ≥98% (HPLC), lyophilized powder
Packaging: 0.1mg
Price: $264
Updated: 2024/03/01

Sigma-Aldrich

Product number: M5060
Product name: E-4031
Purity: ≥98% (HPLC), lyophilized powder
Packaging: 0.5mg
Price: $458.4
Updated: 2024/03/01

Cayman Chemical

Product number: 15203
Product name: E-4031 (hydrochloride)
Purity: ≥98%
Packaging: 5mg
Price: $81
Updated: 2024/03/01

Cayman Chemical

Product number: 15203
Product name: E-4031 (hydrochloride)
Purity: ≥98%
Packaging: 10mg
Price: $143
Updated: 2024/03/01

Sigma-Aldrich

Product number: M5060
Product name: E-4031
Purity: ≥98% (HPLC), solid
Packaging: 1mg
Price: $1340
Updated: 2024/03/01

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E-4031 Chemical Properties,Usage,Production

Uses

E-4031 has been used as:

human ether-a-go-go-related gene (hERG) blocker in human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs)
IKr blocker in long QT syndrome (LQTS) induced pluripotent stem (iPSCs) embryoid bodies
IKr blocker in rat ventricular myocytes

Biological Activity

Selective blocker of hERG K + channels; inhibits the rapid delayed-rectifier K + current (I Kr ). Reversibly prolongs action potential duration in guinea pig papillary muscle and isolated ventricular myocytes, without affecting Na + or Ca 2+ inward currents. Class III antiarrhythmic agent.

Biochem/physiol Actions

E-4031 is a antiarrhythmic drug and belongs to the class III type. It is a methanesulfonanilide compound and is effective in treating arrhythmia and modulates ventricular fibrillation. E-4031 mediates the prolongation of action potential duration (APD) in transgenic long-QT type 1 (LQT1) rabbits. An isoleucine mutation in human ether-a-go-go-related gene (hERG) abolishes its interaction with E-4031.

storage

Room temperature (desiccate)

E-4031 Preparation Products And Raw materials

Raw materials

Preparation Products

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E-4031 Suppliers

China 59 Germany 3 Japan 1 Switzerland 1 United Kingdom 4 United States 16 Global 84

MedChemexpress LLC

Tel: 021-58955995
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AdooQ BioScience, LLC

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Musechem

Tel: +1-800-259-7612
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Email: info@musechem.com
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
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ProdList: 32161
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Alfa Chemistry

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BOC Sciences

Tel: +1-631-485-4226
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Email: inquiry@bocsci.com
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Aladdin Scientific

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TargetMol Chemicals Inc.

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ApexBio Technology

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BOC Sciences

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Abcam

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Cayman Chemical Company

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MedChemExpress

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Riedel-de Haen AG

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Santa Cruz Biotechnology, Inc.

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BIOMOL INTERNATIONAL, LP

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View Lastest Price from E-4031 manufacturers

Career Henan Chemical Co

Product: E-4031 113559-13-0
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 200kg
Release date: 2020-01-13

113559-13-0, E-4031Related Search:

N-Methylbenzylamine N,N-DIETHYL-N-[2-(2-PYRIDYL)ETHYL]AMINE 4-BENZOYLPIPERIDINE HYDROCHLORIDE Betahistine dihydrochloride N-(4-ACETYL-PHENYL)-METHANESULFON-AMIDE E-4031,E-4031 DIHYDROCHLORIDE 4-(4-PIPERIDINYLMETHYL)-BENZENAMINE 4-(PHENYLMETHYL)-PIPERIDINE HYDROCHLORIDE 1-[2-(2-PYRIDYL)ETHYL]PIPERIDINE E-4031 2-(2'-AMINOETHYL)-6-METHYLPYRIDINE RARECHEM AL F1 4031 AURORA KA-4031 RARECHEM AK PP 4031 AKOS BB-4031 AURORA 4031 E-4031, Voltage-Gated (HERG) K+ Channel Blocker, 510.48MW

1-(2-(6-methyl-2-pyridyl)ethyl)-4-(4-methylsulfonylaminobenzoyl)piperidined

methanesulfonamide,n-(4-((1-(2-(6-methyl-2-pyridinyl)ethyl)-4-piperidinyl)carb

E-4031

N-[4-[[1-[2-(6-Methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]methanesulfonamide dihydrochloride

N-[4-[1-[2-(6-Methyl-2-pyridinyl)ethyl]-4-piperidinylcarbonyl]phenyl]methanesulfonamide·2hydrochloric acid

E-4031 (hydrochloride)

N-(4-(1-(2-(6-METHYLPYRIDIN-2-YL)ETHYL)PIPERIDINE-4-CARBONYL)PHENYL)METHANESULFONAMIDE 2HCL

N-[4-[1-[2-(6-methylpyridin-2-yl)ethyl]piperidine-4-carbonyl]phenyl]methanesulfonamide dihydrochloride

Inhibitor,anti-arrhythmic,Potassium Channel,E4031,E 4031,KcsA,inhibit,E-4031,hERG

E4031 diHCl

Methanesulfonamide, N-[4-[[1-[2-(6-methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]-, hydrochloride (1:2)

E-4031 dihydrochloride, HERG K+ channel blocker

113559-13-0

C21H27N3O3S2HCl

Cell Biology

Cell Signaling and Neuroscience

Monovalent Ion Channels

Ion Channels

Potassium Channel Modulators

Voltage-gated Ion Channels

BioChemical

Potassium channel

Ion Channels