TERT-BUTYL 4-(2-HYDROXYETHYL)PIPERAZINE-1-CARBOXYLATE
- Product Name
- TERT-BUTYL 4-(2-HYDROXYETHYL)PIPERAZINE-1-CARBOXYLATE
- CAS No.
- 77279-24-4
- Chemical Name
- TERT-BUTYL 4-(2-HYDROXYETHYL)PIPERAZINE-1-CARBOXYLATE
- Synonyms
- BUTTPARK 46\04-31;Boc-Piperazine-OH;BOC-N-(2-HYDROXYETHYL)PIPERAZINE;1-Boc-4-(2-hydroxyethyl)-piperazi;1-BOC-4-(2-HYDROXYETHYL)-PIPERAZINE;N-Boc-N’-(2-hydroxyethyl)-piperazine;1-Boc-4-(2-hydroxyethyl)piperazine 97%;N-BOC-Nzzhlxy-(2-hydroxyethyl)piperazine;tert-Butyl 4-(2-hydroxyethyl)piperazine-1-;4-(2-HYDROXYETHYL)PIPERAZINE-1-CARBOXYLATE
- CBNumber
- CB8389646
- Molecular Formula
- C11H22N2O3
- Formula Weight
- 230.3
- MOL File
- 77279-24-4.mol
TERT-BUTYL 4-(2-HYDROXYETHYL)PIPERAZINE-1-CARBOXYLATE Property
- Melting point:
- 38-42 °C
- Boiling point:
- 114°C 0,1mm
- Density
- 1.092±0.06 g/cm3(Predicted)
- Flash point:
- 110 °C
- storage temp.
- 2-8°C
- pka
- 14.96±0.10(Predicted)
- form
- Solid
- color
- White to pale brown
- InChI
- InChI=1S/C11H22N2O3/c1-11(2,3)16-10(15)13-6-4-12(5-7-13)8-9-14/h14H,4-9H2,1-3H3
- InChIKey
- VRXIOAYUQIITBU-UHFFFAOYSA-N
- SMILES
- N1(C(OC(C)(C)C)=O)CCN(CCO)CC1
- CAS DataBase Reference
- 77279-24-4(CAS DataBase Reference)
Safety
- Hazard Codes
- C,N,T
- Risk Statements
- 36/37/38-50-25
- Safety Statements
- 26-36/37/39-61-45
- RIDADR
- UN 2811 6.1/PG 3
- WGK Germany
- 3
- Hazard Note
- Irritant
- HazardClass
- 6.1
- PackingGroup
- Ⅲ
- HS Code
- 2933599590
N-Bromosuccinimide Price
- Product number
- 685909
- Product name
- 1-Boc-4-(2-hydroxyethyl)piperazine
- Purity
- 97%
- Packaging
- 5g
- Price
- $130
- Updated
- 2023/06/20
- Product number
- B6368
- Product name
- tert-Butyl 4-(2-Hydroxyethyl)piperazine-1-carboxylate
- Purity
- min. 98.0 %
- Packaging
- 5G
- Price
- $41
- Updated
- 2025/07/31
- Product number
- B6368
- Product name
- tert-Butyl 4-(2-Hydroxyethyl)piperazine-1-carboxylate
- Purity
- min. 98.0 %
- Packaging
- 25G
- Price
- $122
- Updated
- 2025/07/31
- Product number
- B943578
- Product name
- tert-Butyl4-(2-hydroxyethyl)piperazine-1-carboxylate
- Packaging
- 5g
- Price
- $130
- Updated
- 2021/12/16
- Product number
- B943578
- Product name
- tert-Butyl4-(2-hydroxyethyl)piperazine-1-carboxylate
- Packaging
- 1g
- Price
- $45
- Updated
- 2021/12/16
TERT-BUTYL 4-(2-HYDROXYETHYL)PIPERAZINE-1-CARBOXYLATE Chemical Properties,Usage,Production
Uses
Boc-Piperazine-OH is a PROTAC Linker in SJ46420 (HY-168635)[1].
Synthesis
103-76-4
24424-99-5
77279-24-4
General procedure: synthesis of tert-butyl 4-(2-hydroxyethyl)piperazine-1-carboxylate (57): 1-(2-hydroxyethyl)piperazine (3.0 g, 23.0 mmol) was dissolved in dry tetrahydrofuran (THF) under nitrogen protection. Subsequently, di-tert-butyl dicarbonate (5.5 g, 25.3 mmol) was slowly added to this solution. The reaction mixture was stirred at room temperature for 2 hours. After completion of the reaction, the solvent was evaporated to half of the initial volume by rotary evaporator. The concentrated mixture was poured into deionized water and extracted with dichloromethane (CH2Cl2). The organic phases were combined, washed with saturated saline and dried over anhydrous sodium sulfate (Na2SO4). After filtration, the filtrate was concentrated under reduced pressure to afford the light yellow oily product tert-butyl 4-(2-hydroxyethyl)piperazine-1-carboxylate (5.3 g, quantitative yield). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 1.46 (s, 9H), 2.44-2.46 (m, 4H), 2.54-2.57 (m, 2H), 2.66 (m, J = 5.3 Hz, 1H), 3.42-3.45 (m, 4H), 3.62 (q, J = 5.3 Hz, 2H).
References
[1] Scott DC, et al. Principles of paralog-specific targeted protein degradation engaging the C-degron E3 KLHDC2. Nat Commun. 2024 Oct 12;15(1):8829. DOI:10.1038/s41467-024-52966-3
TERT-BUTYL 4-(2-HYDROXYETHYL)PIPERAZINE-1-CARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
TERT-BUTYL 4-(2-HYDROXYETHYL)PIPERAZINE-1-CARBOXYLATE Suppliers
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- Product
- TERT-BUTYL 4-(2-HYDROXYETHYL)PIPERAZINE-1-CARBOXYLATE 77279-24-4
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-03