ChemicalBook > CAS DataBase List > 11-OXO-PROSTA-5Z,12E,14Z-TRIEN-1-OIC ACID

11-OXO-PROSTA-5Z,12E,14Z-TRIEN-1-OIC ACID

Product Name
11-OXO-PROSTA-5Z,12E,14Z-TRIEN-1-OIC ACID
CAS No.
596104-94-8
Chemical Name
11-OXO-PROSTA-5Z,12E,14Z-TRIEN-1-OIC ACID
Synonyms
CAY10410;CAY10410,CAY-10410;AFBJLDUEEOOVHL-WKELIDJCSA-N;11-OXO-PROSTA-5Z,12E,14Z-TRIEN-1-OIC ACID;9,10-dihydro-15-deoxy-Δ12,14-Prostaglandin J2;9,10-DIHYDRO-15-DEOXY-DELTA12,14-PROSTAGLANDIN J2;Prosta-5,12,14-trien-1-oic acid, 11-oxo-, (5Z,12E,14Z)-
CBNumber
CB8389954
Molecular Formula
C20H30O3
Formula Weight
318.45
MOL File
Mol file
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11-OXO-PROSTA-5Z,12E,14Z-TRIEN-1-OIC ACID Property

storage temp. 
Store at -20°C
solubility 
DMF: 100 mg/ml; DMSO: 20 mg/ml; Ethanol: 75 mg/ml; PBS (7.2): 2.7 mg/ml
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

H336May cause drowsiness or dizziness

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
18590
Product name
CAY10410
Purity
≥98% (isomer mixture)
Packaging
500μg
Price
$87
Updated
2024/03/01
Cayman Chemical
Product number
18590
Product name
CAY10410
Purity
≥98% (isomer mixture)
Packaging
1mg
Price
$163
Updated
2024/03/01
Cayman Chemical
Product number
18590
Product name
CAY10410
Purity
≥98% (isomer mixture)
Packaging
5mg
Price
$680
Updated
2024/03/01
Cayman Chemical
Product number
18590
Product name
CAY10410
Purity
≥98% (isomer mixture)
Packaging
10mg
Price
$1189
Updated
2024/03/01
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11-OXO-PROSTA-5Z,12E,14Z-TRIEN-1-OIC ACID Chemical Properties,Usage,Production

Description

CAY10410 is an analog of prostaglandin D2/prostaglandin J2 (PGD2/PGJ2) with structural modifications intended to give it PPARγ ligand activity and resistance to metabolism. 15-deoxy-Δ12,14-PGJ2 has been shown to be a potent ligand for PPARγ.1 Metabolism of the cyclopentenone prostaglandins PGA2, PGJ2, and Δ12-PGJ2 occurs via glutathione addition across the α,β unsaturated enone.2 CAY10410 was designed as an analog of the PPARγ-binding prostaglandins which could not undergo this conjugation reaction. In human neuroblastoma SH-SY5Y cells, CAY10410 was not cytotoxic at up to 25 μM. It also failed to covalently modify thioredoxin or induce oxidative stress at 50 μM.3

References

1. Forman, B.M., Tontonoz, P., Chen, J., et al. 15-Deoxy-Δ12,14-prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ Cell 83(5),803-812(1995).
2. Atsmon, J., Sweetman, B.J., Baertschi, S.W., et al. Formation of thiol conjugates of 9-deoxy-Δ9,Δ12(E)-prostaglandin D2 and Δ12(E)-prostaglandin D2 Biochemistry 29,3760-3765(1990).
3. Shibata, T., Yamada, T., Ishii, T., et al. Thioredoxin as a molecular target of cyclopentenone prostaglandins J. Biol. Chem. 278(28),26046-26054(2003).

11-OXO-PROSTA-5Z,12E,14Z-TRIEN-1-OIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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11-OXO-PROSTA-5Z,12E,14Z-TRIEN-1-OIC ACID Suppliers

China 12 United States 3 Global 15
Dalian Meilun Biotech Co., Ltd.
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0411-62910999 13889544652
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meilunui@163.com
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China
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Shanghai Hongye Biotechnology Co. Ltd
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400-9205774
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sales@glpbio.cn
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China
ProdList
6777
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58
Hangzhou Synstar pharmaceutical Technology CO.,Ltd
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0571-85361029
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0571-85361029
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synstar518@163.com
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China
ProdList
1990
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Nantong Feiyu Biological Technology CO.,LTD
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0513-68819626; 15152877458
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0513-68669626
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feiyubio@163.com
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TargetMol Chemicals Inc.
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4008200310
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marketing@tsbiochem.com
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Shanghai Yifei Biotechnology Co. , Ltd.
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021-65675885 18964387627
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customer_service@efebio.com
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Shanghai Hao Zhun Biological Technology Co., Ltd.
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Shanghai Haoran Biotechnology Co., Ltd.
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Shenzhen Xinbosheng Biological Technology Co., Ltd.
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Beijing Bolide Biotechnology Co., Ltd.
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Beijing Shengke Boyuan Biotechnology Co., Ltd.
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596104-94-8, 11-OXO-PROSTA-5Z,12E,14Z-TRIEN-1-OIC ACIDRelated Search:

PROSTAGLANDIN J2

  • 11-OXO-PROSTA-5Z,12E,14Z-TRIEN-1-OIC ACID
  • 9,10-DIHYDRO-15-DEOXY-DELTA12,14-PROSTAGLANDIN J2
  • CAY10410
  • 9,10-dihydro-15-deoxy-Δ12,14-Prostaglandin J2
  • AFBJLDUEEOOVHL-WKELIDJCSA-N
  • Prosta-5,12,14-trien-1-oic acid, 11-oxo-, (5Z,12E,14Z)-
  • CAY10410,CAY-10410
  • 596104-94-8