PROSTAGLANDIN J2

Product Name: PROSTAGLANDIN J2
CAS No.: 60203-57-8
Chemical Name: PROSTAGLANDIN J2
Synonyms: PGJ2;Aids058772;Aids-058772;PROSTAGLANDIN J2;PGJ2 (Prostaglandin J2);Prostaglandin J2 (PGJ2);Prostaglandin J2, PGD2 analog;9-deoxy-delta-9-prostaglandind2;Prostaglandin J2 Lipid Maps MS Standard;PROSTAGLANDIN J2, 5MG/ML IN METHYL ACETA
CBNumber: CB4477024
Molecular Formula: C20H30O4
Formula Weight: 334.45
MOL File: 60203-57-8.mol

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PROSTAGLANDIN J2 Property

Boiling point:: 521.7±50.0 °C(Predicted)
Density: 1.103±0.06 g/cm3(Predicted)
storage temp.: −20°C
solubility: DMF: >100 mg/ml (from PGD2); DMSO: >50 mg/ml (from PGD2); Ethanol: >75 mg/ml (from PGD2); PBS pH 7.2: >2.7 mg/ml (from 15-deoxy-.DEL
pka: 4.75±0.10(Predicted)
form: Liquid
color: Colorless to light yellow

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Safety

Hazard Codes: Xn,Xi,F
Risk Statements: 20/21/22-36/37/38-67-66-36-11
Safety Statements: 26-36-33-29-16

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

H336May cause drowsiness or dizziness

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 18500
Product name: Prostaglandin J2
Purity: ≥95%
Packaging: 500μg
Price: $86
Updated: 2024/03/01

Cayman Chemical

Product number: 18500
Product name: Prostaglandin J2
Purity: ≥95%
Packaging: 1mg
Price: $161
Updated: 2024/03/01

Cayman Chemical

Product number: 18500
Product name: Prostaglandin J2
Purity: ≥95%
Packaging: 5mg
Price: $671
Updated: 2024/03/01

Cayman Chemical

Product number: 18500
Product name: Prostaglandin J2
Purity: ≥95%
Packaging: 10mg
Price: $1172
Updated: 2024/03/01

TRC

Product number: P294203
Product name: PGJ2(ProstaglandinJ2)
Packaging: 1mg
Price: $180
Updated: 2021/12/16

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PROSTAGLANDIN J2 Chemical Properties,Usage,Production

Description

Prostaglandin J₂ (PGJ₂) is formed from PGD₂ by the elimination of the C-9 hydroxyl group, a process which is accelerated by the presence of albumin. PGJ₂ inhibits platelet aggregation with an IC₅₀ of about 5-10 nM. PGJ₂ has antimitotic and antiproliferative effects on a variety of cultured normal cells and tumor cell lines. However, this activity has been attributed to further metabolites of PGJ₂ and not the parent compound itself.

Uses

PGJ2 (Prostaglandin J2) is a Prostaglandin D2 metabolite that has shown potent anti-neoplastic and antiviral activity.

Definition

ChEBI: A member of the class of prostaglandins J that consists of prosta-5,9,13-trien-1-oic acid substituted by an oxo group at position 11 and a hydroxy group at position 15 (the 5Z,13E,15S stereoisomer).

in vivo

Prostaglandin J2 (PGJ2; 33.4 μg/injection; unilateral injection to the SNpc; once per week for 2 or 4 weeks) induces progressive PD-like pathology and exhibites microglia and astrocyte activation and motor deficits in the rats^[4].

Animal Model:	Sixteen-week-old Sprague Dawley male rats^[4]
Dosage:	33.4 μg/injection
Administration:	Unilateral (right side) injections to the SNpc; once per week for 2 or 4 weeks
Result:	Induced progressive dopaminergic neuronal loss in the rat substantia nigra pars compacta (SNpc). Developed parkinsonian-like motor deficits in a progressive manner.

IC 50

hDP: 0.9 nM (Ki); hCRTH2: 6.6 nM (Ki); hEP1: 15.678 μM (Ki); hEP2: 989 nM (Ki); hEP3: 319 nM (Ki); hEP4: 1065 nM (Ki); hFP: 553 nM (Ki); hIP: >25 μM (Ki); hTP: 6426 nM (Ki); Human Endogenous Metabolite

References

[1] D. HAMISH WRIGHT. Characterization of the recombinant human prostanoid DP receptor and identification of L-644,698, a novel selective DP agonist[J]. British Journal of Pharmacology, 2009, 123 7: 1317-1324. DOI: 10.1038/sj.bjp.0701708
[2] NICOLE SAWYER. Molecular pharmacology of the human prostaglandin D2 receptor, CRTH2[J]. British Journal of Pharmacology, 2009, 137 8: 1163-1172. DOI: 10.1038/sj.bjp.0704973
[3] TENEKA JEAN-LOUIS Maria E F P Patricia Rockwell. Prostaglandin J2 promotes O-GlcNAcylation raising APP processing by α- and β-secretases: relevance to Alzheimer’s disease[J]. Neurobiology of Aging, 2018, 62: Pages 130-145. DOI: 10.1016/j.neurobiolaging.2017.10.009
[4] MARIA E. FIGUEIREDO-PEREIRA John B Chuhyon Corwin. Prostaglandin J2: a potential target for halting inflammation-induced neurodegeneration?[J]. Annals of the New York Academy of Sciences, 2016, 1363 1: 125-137. DOI: 10.1111/nyas.12987
[5] CHUHYON CORWIN. Prostaglandin D2/J2 signaling pathway in a rat model of neuroinflammation displaying progressive parkinsonian-like pathology: potential novel therapeutic targets.[J]. Journal of Neuroinflammation, 2018: 272. DOI: 10.1186/s12974-018-1305-3
[6] ABHITA MALAVIYA Paul W S. Synergistic Antiproliferative Effects of Combined γ -Tocotrienol and PPAR γ Antagonist Treatment Are Mediated through PPAR γ -Independent Mechanisms in Breast Cancer Cells.[J]. PPAR Research, 2014: 439146. DOI: 10.1155/2014/439146

PROSTAGLANDIN J2 Preparation Products And Raw materials

Raw materials

Preparation Products

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PROSTAGLANDIN J2 Suppliers

China 33 Germany 2 Japan 2 Switzerland 1 United Kingdom 1 United States 7 USA 1 Global 47

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 13167063860
Fax: 021-50323701
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ProdList: 25003
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Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
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Aikon International Limited

Tel: 025-58851090 15955137747
Fax: (6)02557626880
Email: sales01@aikonchem.com
Country: China
ProdList: 15949
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Career Henan Chemica Co

Tel: +86-0371-86658258 +8613203830695
Fax: 0371-86658258
Email: laboratory@coreychem.com
Country: China
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
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Energy Chemical

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Shanghai Universal Biotech Co.,Ltd

Tel: 15921930842 15921930842
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amyjetsci

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TargetMol Chemicals Inc.

Tel: 4008200310
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Hubei Aiputi Bioengineering Co., Ltd.

Tel: 17762444226
Email: d17762444226@163.com
Country: China
ProdList: 2402
Advantage: 58

60203-57-8, PROSTAGLANDIN J2Related Search:

PROSTAGLANDIN A1 Latanoprost acid PROSTAGLANDIN G2 Latanoprost Prostaglandin E2 PROSTAGLANDIN A2 Latanoprost Lactone Diol 2-Cyclopenten-1-one PROSTAGLANDIN J2 TRANS,CIS-2,6-NONADIEN-1-OL Carboprost ENPROSTIL PROSTAGLANDIN D2 Inositol PROSTAGLANDIN B2 Latanoprost Lactol Fluprostenol PROSTAGLANDIN B1

11-OXO-15S-HYDROXY-PROSTA-5Z,9,13E-TRIEN-1-OIC ACID

(5Z,13E,15S)-15-HYDROXY-11-OXOPROSTA-5,9,13-TRIEN-1-OIC ACID

PROSTAGLANDIN J2

PGJ2

9-deoxy-delta-9-prostaglandind2

PROSTAGLANDIN J2, 5MG/ML IN METHYL ACETA

(Z)-7-[(1S,5R)-5-[(E,3S)-3-hydroxyoct-1-enyl]-4-oxo-1-cyclopent-2-enyl]hept-5-enoic acid

(5Z,13E,15S)-15-Hydroxy-11-oxoprosta-5,9,13-triene-1-oic acid

Aids058772

Aids-058772

Prosta-5,9,13-trien-1-oic acid, 15-hydroxy-11-oxo-, (5Z,13E,15S)-

Prostaglandin J2 Lipid Maps MS Standard

PGJ2 (Prostaglandin J2)

Prostaglandin J2 (PGJ2)

Prostaglandin J2, PGD2 analog

60203-57-8