Latanoprost acid

Product Name: Latanoprost acid
CAS No.: 41639-83-2
Chemical Name: Latanoprost acid
Synonyms: (5Z)-;LAT-FA;LT-Acid;PHXA 85;LATANOPROST ACID;latanoprostfreeaci;LATANOPROST (FREE ACID);LATANOPROSTACID;PHXA 85;Latanoprost Impurity 23;LT-ACID(LATANOPROST ACID)
CBNumber: CB4208385
Molecular Formula: C23H34O5
Formula Weight: 390.51
MOL File: 41639-83-2.mol

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Latanoprost acid Property

Boiling point:: 609.1±50.0 °C(Predicted)
Density: 1.159±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMSO: freely soluble
form: Oil
pka: 4.76±0.10(Predicted)
color: pale yellow, oil
optical activity: [α]/D 26.0 to 36.0°, c =0.1 in methanol
Stability:: Hygroscopic
InChIKey: HNPFPERDNWXAGS-NFVOFSAMSA-N
SMILES: C(O)(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCC1=CC=CC=C1

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Safety

WGK Germany: 3
HS Code: 2937500000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: L1292
Product name: Latanoprost acid
Purity: ≥98% (HPLC)
Packaging: 1mg
Price: $188
Updated: 2024/03/01

Sigma-Aldrich

Product number: Y0002205
Product name: Latanoprost impurity H
Purity: CRS European Pharmacopoeia (EP) Reference Standard
Packaging: Y0002205
Price: $1970
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1357533
Product name: Latanoprost Related Compound E
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 25mg
Price: $1850
Updated: 2024/03/01

Cayman Chemical

Product number: 16811
Product name: Latanoprost (free acid)
Purity: ≥98%
Packaging: 1mg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 16811
Product name: Latanoprost (free acid)
Purity: ≥98%
Packaging: 5mg
Price: $302
Updated: 2024/03/01

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Latanoprost acid Chemical Properties,Usage,Production

Description

Latanoprost is an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug. Latanoprost is an isopropyl ester, a prodrug form which is converted to latanoprost (free acid) by endogenous esterase enzymes. The free acid form is 200 times more potent than latanoprost as an FP receptor ligand for the human recombinant FP receptor. Latanoprost is the isopropyl ester of a PGF_2α analog containing an aromatic group (17-phenyl) in the ω-chain. Lat-FA is the corresponding carboxylic acid of this analog. Lat-FA is a potent FP receptor agonist with an EC₅₀ of 3.6 nM for human FP receptors, which is twice the potency of PGF_2α. The efficacy of PG analog esters for the treatment of glaucoma correlates closely with the FP receptor binding affinity of the free acid. However, Lat-FA is more irritating and less effective than the prodrug latanoprost when applied directly to the eyes of human glaucoma patients.

Chemical Properties

Pale Yellow Oil

Uses

A metabolite of Latanoprost. Potent, selective FP prostanoid receptor agonist. F-series Prostaglandin analog. 200 times as potent as isopropyl ester form. Latanoprost USP Related Compound E.

Definition

ChEBI: Latanoprost free acid is a prostaglandin Falpha that is an analogue of prostaglandin F2alpha in which the pentyl group has been replaced by 2-phenylethyl and where the the 13,14-double bond has undergone formal hydrogenation. Its isopropyl ester prodrug, latanoprost, is used in the treatment of open-angle glaucoma and ocular hypertension. It has a role as an antiglaucoma drug, an antihypertensive agent and an EC 4.2.1.1 (carbonic anhydrase) inhibitor. It is a prostaglandins Falpha and a hydroxy monocarboxylic acid.

Biochem/physiol Actions

Potent, selective FP prostanoid receptor agonist, F-series prostaglandin analog. 200 times as potent as isopropyl ester form.

Latanoprost acid Preparation Products And Raw materials

Raw materials

Preparation Products

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Latanoprost acid Suppliers

Canada 2 China 96 Europe 2 Germany 1 India 9 South Korea 1 Switzerland 1 United Kingdom 2 United States 12 Global 126

J & K SCIENTIFIC LTD.

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Adamas Reagent, Ltd.

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Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

China DongFan Chemical Co.,LTD

Tel: 86-0571-85151182
Fax: 86-0571-85151182
Country: China
ProdList: 5691
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XiaoGan ShenYuan ChemPharm co,ltd

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Country: China
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Sinopharm Chemical Reagent Co,Ltd.

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ProdList: 9815
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Shanghai Aladdin Bio-Chem Technology Co.,LTD

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Shanghai TaoSu Biochemical Technology Co., Ltd.

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ChemStrong Scientific Co.,Ltd

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Shanghai YuLue Chemical Co., Ltd.

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Fax: 021-34702061
Email: lzz841106@aliyun.com
Country: China
ProdList: 10274
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View Lastest Price from Latanoprost acid manufacturers

Career Henan Chemical Co

Product: Latanoprost acid 41639-83-2
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-02-16

41639-83-2, Latanoprost acidRelated Search:

Latanoprost Epoxide (Mixture of isoMers) Latanoprost Tris(triethylsilyl) Ether NCX 116 15-KETO LATANOPROST (5Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-(3-oxo-5-phenylpentyl)cyclopentyl]-5-heptenoic Acid 15(S)-Latanoprost Latanoprost Lactone Diol trans Latanoprost CHLOROPHOSPHONAZO III Prostaglandin E2 Latanoprost Citric acid Ethyl 2-(Chlorosulfonyl)acetate Prostaglandin E1 Folic acid Ascoric Acid Latanoprost Impurity 1 Latanoprost Impurity (Diphenylphosphine Isopropyl Ester)

LATANOPROST (FREE ACID)

LAT-FA

17-PHENYL-13,14-DIHYDRO TRINOR PROSTAGLANDIN F2ALPHA

(5Z,9ALPHA,11ALPHA,15R)-9,11,15-TRIHYDROXY-17-PHENYL-18,19,20-TRINOR-PROST-5-EN-1-OIC ACID

9ALPHA, 11ALPHA, 15R-TRIHYDROXY-17-PHENYL-18,19,20-TRINOR-PROST-5Z-EN-1-OIC ACID

PHXA 85

PhXA 85, (5Z,9α,11α,15R)-9,11,15-Trihydroxy-17-phenyl-18,19,20-trinor-prost-5-en-1-oic acid

Latanoprost acid,(5Z,9α,11α,15R)-9,11,15-Trihydroxy-17-phenyl-18,19,20-trinor-prost-5-en-1-oic acid, PhXA 85

LT-ACID(LATANOPROST ACID)

LT-Acid

(5z,9α,11α,15r)-9,11,15-trihydroxy-17-phenyl-18,19,20-trinor-prost-5-en-1-oic acid

(Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoic acid

LATANOPROST ACID

(5Z)-

Latanoprost Related CoMpound E

Latanoprost Related Compound E (25 mg) ((Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl}-5-heptenoic acid)

(Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl}-5-heptenoic acid

LT-Acid(Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoic acid

LATANOPROSTACID;PHXA 85

(Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((R)-3-hydroxy-5-phenylpentyl)cyclopentyl)hept-5-enoic acid

Latanoprost Impurity 8（Latanoprost Acid）

Latanoprost Acid/(Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoic acid

5-Heptenoic acid, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]-, (5Z)-

latanoprostfreeaci

Latanoprost Related Compound E ((Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl (1357533)

Latanoprost Impurity 23

Latanoprost EP Impurity H

Latanoprost EP Impurity H (Latanoprost USP Related Compound E)

Latanoprost Acid / Latanoprost Related Compound-E

Latanoprost acid (related compound E)

(5Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]-5-heptenoic acid

Latanoprost acid, 10 mM in DMSO

41639-83-2

7130209-82-4

C26H40O5

C23H35O5

Aromatics, Chiral Reagents, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals

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Intermediates & Fine Chemicals

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