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Latanoprost acid

Product Name
Latanoprost acid
CAS No.
41639-83-2
Chemical Name
Latanoprost acid
Synonyms
(5Z)-;LAT-FA;LT-Acid;PHXA 85;LATANOPROST ACID;latanoprostfreeaci;LATANOPROST (FREE ACID);LATANOPROSTACID;PHXA 85;Latanoprost Impurity 23;LT-ACID(LATANOPROST ACID)
CBNumber
CB4208385
Molecular Formula
C23H34O5
Formula Weight
390.51
MOL File
41639-83-2.mol
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Latanoprost acid Property

Boiling point:
609.1±50.0 °C(Predicted)
Density 
1.159±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMSO: freely soluble
form 
Oil
pka
4.76±0.10(Predicted)
color 
pale yellow, oil
Stability:
Hygroscopic
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Safety

WGK Germany 
3
HS Code 
2937500000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
L1292
Product name
Latanoprost acid
Purity
≥98% (HPLC)
Packaging
1mg
Price
$188
Updated
2024/03/01
Sigma-Aldrich
Product number
Y0002205
Product name
Latanoprost impurity H
Purity
CRS European Pharmacopoeia (EP) Reference Standard
Packaging
Y0002205
Price
$1970
Updated
2024/03/01
Sigma-Aldrich
Product number
1357533
Product name
Latanoprost Related Compound E
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
25mg
Price
$1850
Updated
2024/03/01
Cayman Chemical
Product number
16811
Product name
Latanoprost (free acid)
Purity
≥98%
Packaging
1mg
Price
$68
Updated
2024/03/01
Cayman Chemical
Product number
16811
Product name
Latanoprost (free acid)
Purity
≥98%
Packaging
5mg
Price
$302
Updated
2024/03/01
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Latanoprost acid Chemical Properties,Usage,Production

Description

Latanoprost is an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug. Latanoprost is an isopropyl ester, a prodrug form which is converted to latanoprost (free acid) by endogenous esterase enzymes. The free acid form is 200 times more potent than latanoprost as an FP receptor ligand for the human recombinant FP receptor. Latanoprost is the isopropyl ester of a PGF2α analog containing an aromatic group (17-phenyl) in the ω-chain. Lat-FA is the corresponding carboxylic acid of this analog. Lat-FA is a potent FP receptor agonist with an EC50 of 3.6 nM for human FP receptors, which is twice the potency of PGF2α. The efficacy of PG analog esters for the treatment of glaucoma correlates closely with the FP receptor binding affinity of the free acid. However, Lat-FA is more irritating and less effective than the prodrug latanoprost when applied directly to the eyes of human glaucoma patients.

Chemical Properties

Pale Yellow Oil

Uses

A metabolite of Latanoprost. Potent, selective FP prostanoid receptor agonist. F-series Prostaglandin analog. 200 times as potent as isopropyl ester form. Latanoprost USP Related Compound E.

Definition

ChEBI: A prostaglandin Falpha that is an analogue of prostaglandin F2alpha in which the pentyl group has been replaced by 2-phenylethyl and where the the 13,14-double bond has undergone f rmal hydrogenation. Its isopropyl ester prodrug, latanoprost, is used in the treatment of open-angle glaucoma and ocular hypertension.

Biochem/physiol Actions

Potent, selective FP prostanoid receptor agonist, F-series prostaglandin analog. 200 times as potent as isopropyl ester form.

Latanoprost acid Preparation Products And Raw materials

Raw materials

Preparation Products

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Latanoprost acid Suppliers

Canada 2 China 91 Europe 2 Germany 1 India 10 South Korea 1 Switzerland 1 United Kingdom 2 United States 12 Global 122
Service Chemical Inc.
Tel
--
Fax
--
Email
sales@chemos-group.com
Country
Germany
ProdList
6350
Advantage
71
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View Lastest Price from Latanoprost acid manufacturers

Career Henan Chemical Co
Product
Latanoprost acid 41639-83-2
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2020-02-16

41639-83-2, Latanoprost acidRelated Search:

Latanoprost Epoxide (Mixture of isoMers) Latanoprost Tris(triethylsilyl) Ether NCX 116 15-KETO LATANOPROST (5Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-(3-oxo-5-phenylpentyl)cyclopentyl]-5-heptenoic Acid 15(S)-Latanoprost Latanoprost Lactone Diol trans Latanoprost CHLOROPHOSPHONAZO III Prostaglandin E2 Latanoprost Citric acid Ethyl 2-(Chlorosulfonyl)acetate Prostaglandin E1 Folic acid Ascoric Acid Latanoprost Impurity 1 Latanoprost Impurity (Diphenylphosphine Isopropyl Ester)

  • LATANOPROST (FREE ACID)
  • LAT-FA
  • 17-PHENYL-13,14-DIHYDRO TRINOR PROSTAGLANDIN F2ALPHA
  • (5Z,9ALPHA,11ALPHA,15R)-9,11,15-TRIHYDROXY-17-PHENYL-18,19,20-TRINOR-PROST-5-EN-1-OIC ACID
  • 9ALPHA, 11ALPHA, 15R-TRIHYDROXY-17-PHENYL-18,19,20-TRINOR-PROST-5Z-EN-1-OIC ACID
  • PHXA 85
  • PhXA 85, (5Z,9α,11α,15R)-9,11,15-Trihydroxy-17-phenyl-18,19,20-trinor-prost-5-en-1-oic acid
  • Latanoprost acid,(5Z,9α,11α,15R)-9,11,15-Trihydroxy-17-phenyl-18,19,20-trinor-prost-5-en-1-oic acid, PhXA 85
  • LT-ACID(LATANOPROST ACID)
  • LT-Acid
  • (5z,9α,11α,15r)-9,11,15-trihydroxy-17-phenyl-18,19,20-trinor-prost-5-en-1-oic acid
  • (Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoic acid
  • LATANOPROST ACID
  • (5Z)-
  • Latanoprost Related CoMpound E
  • Latanoprost Related Compound E (25 mg) ((Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl}-5-heptenoic acid)
  • (Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl}-5-heptenoic acid
  • LT-Acid(Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoic acid
  • LATANOPROSTACID;PHXA 85
  • (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((R)-3-hydroxy-5-phenylpentyl)cyclopentyl)hept-5-enoic acid
  • Latanoprost Impurity 8（Latanoprost Acid）
  • Latanoprost Acid/(Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoic acid
  • 5-Heptenoic acid, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]-, (5Z)-
  • latanoprostfreeaci
  • Latanoprost Related Compound E ((Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl (1357533)
  • Latanoprost Impurity 23
  • Latanoprost EP Impurity H
  • Latanoprost EP Impurity H (Latanoprost USP Related Compound E)
  • Latanoprost Acid / Latanoprost Related Compound-E
  • Latanoprost acid (related compound E)
  • (5Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]-5-heptenoic acid
  • 41639-83-2
  • 7130209-82-4
  • C26H40O5
  • C23H35O5
  • Aromatics, Chiral Reagents, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
  • Aromatics
  • Chiral Reagents
  • Intermediates & Fine Chemicals
  • Metabolites & Impurities
  • Pharmaceuticals