Latanoprost acid

ChemicalBook > CAS DataBase List > Latanoprost acid

Product Name: Latanoprost acid
CAS No.: 41639-83-2
Chemical Name: Latanoprost acid
Synonyms: (5Z)-;LAT-FA;LT-Acid;PHXA 85;LATANOPROST ACID;latanoprostfreeaci;LATANOPROST (FREE ACID);LATANOPROSTACID;PHXA 85;Latanoprost Impurity 23;LT-ACID(LATANOPROST ACID)
CBNumber: CB4208385
Molecular Formula: C23H34O5
Formula Weight: 390.51
MOL File: 41639-83-2.mol

Less

Latanoprost acid Property

Boiling point:: 609.1±50.0 °C(Predicted)
Density: 1.159±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMSO: freely soluble
form: Oil
pka: 4.76±0.10(Predicted)
color: pale yellow, oil
Stability:: Hygroscopic

Less

Safety

WGK Germany: 3
HS Code: 2937500000

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: L1292
Product name: Latanoprost acid
Purity: ≥98% (HPLC)
Packaging: 1mg
Price: $188
Updated: 2024/03/01

Sigma-Aldrich

Product number: Y0002205
Product name: Latanoprost impurity H
Purity: CRS European Pharmacopoeia (EP) Reference Standard
Packaging: Y0002205
Price: $1970
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1357533
Product name: Latanoprost Related Compound E
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 25mg
Price: $1850
Updated: 2024/03/01

Cayman Chemical

Product number: 16811
Product name: Latanoprost (free acid)
Purity: ≥98%
Packaging: 1mg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 16811
Product name: Latanoprost (free acid)
Purity: ≥98%
Packaging: 5mg
Price: $302
Updated: 2024/03/01

Less

Latanoprost acid Chemical Properties,Usage,Production

Description

Latanoprost is an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug. Latanoprost is an isopropyl ester, a prodrug form which is converted to latanoprost (free acid) by endogenous esterase enzymes. The free acid form is 200 times more potent than latanoprost as an FP receptor ligand for the human recombinant FP receptor. Latanoprost is the isopropyl ester of a PGF_2α analog containing an aromatic group (17-phenyl) in the ω-chain. Lat-FA is the corresponding carboxylic acid of this analog. Lat-FA is a potent FP receptor agonist with an EC₅₀ of 3.6 nM for human FP receptors, which is twice the potency of PGF_2α. The efficacy of PG analog esters for the treatment of glaucoma correlates closely with the FP receptor binding affinity of the free acid. However, Lat-FA is more irritating and less effective than the prodrug latanoprost when applied directly to the eyes of human glaucoma patients.

Chemical Properties

Pale Yellow Oil

Uses

A metabolite of Latanoprost. Potent, selective FP prostanoid receptor agonist. F-series Prostaglandin analog. 200 times as potent as isopropyl ester form. Latanoprost USP Related Compound E.

Definition

ChEBI: A prostaglandin Falpha that is an analogue of prostaglandin F2alpha in which the pentyl group has been replaced by 2-phenylethyl and where the the 13,14-double bond has undergone f rmal hydrogenation. Its isopropyl ester prodrug, latanoprost, is used in the treatment of open-angle glaucoma and ocular hypertension.

Biochem/physiol Actions

Potent, selective FP prostanoid receptor agonist, F-series prostaglandin analog. 200 times as potent as isopropyl ester form.

Latanoprost acid Preparation Products And Raw materials

Raw materials

Preparation Products

Less

Latanoprost acid Suppliers

Canada 2 China 91 Europe 2 Germany 1 India 10 South Korea 1 Switzerland 1 United Kingdom 2 United States 12 Global 122

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14103
Advantage: 59

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

China DongFan Chemical Co.,LTD

Tel: 86-0571-85151182
Fax: 86-0571-85151182
Country: China
ProdList: 5691
Advantage: 66

XiaoGan ShenYuan ChemPharm co,ltd

Tel: 15527768850
Email: 1791901229@qq.com
Country: China
ProdList: 8838
Advantage: 52

Sinopharm Chemical Reagent Co,Ltd.

Tel: 86-21-63210123
Fax: 86-21-63290778 86-21-63218885
Email: sj_scrc@sinopharm.com
Country: China
ProdList: 9815
Advantage: 79

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-400-6206333 18521732826
Fax: 021-50323701
Email: market@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

Shanghai TaoSu Biochemical Technology Co., Ltd.

Tel: 021-33632979
Fax: 021-34692979
Email: info@tsbiochem.com
Country: China
ProdList: 8065
Advantage: 58

ChemStrong Scientific Co.,Ltd

Tel: 0755-0755-66853366 13670046396
Fax: 0755-28363542
Email: sales@chem-strong.com
Country: China
ProdList: 18042
Advantage: 56

Shanghai YuLue Chemical Co., Ltd.

Tel: 021-60345187 13671753212
Fax: 021-34702061
Email: lzz841106@aliyun.com
Country: China
ProdList: 10276
Advantage: 55

Hangzhou J&H Chemical Co., Ltd.

Tel: 0571-+86-571-87396432
Fax: 0571-87396431
Email: sales@jhechem.com
Country: China
ProdList: 11481
Advantage: 59

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51456
Advantage: 80

Nanjing XiZe Biotechnology CO., Ltd.

Tel: 025-66023220 0086-15250997978
Fax: 025-58362220
Email: 1511893459@qq.com
Country: China
ProdList: 7850
Advantage: 55

Chengdu Dianchun Technology Co., Ltd

Tel: 400-1166-196 18502815961
Fax: QQ：800101999
Email: cdhxsj@163.com
Country: China
ProdList: 14603
Advantage: 60

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973186 4009686088
Email: 3193328036@qq.com
Country: China
ProdList: 18338
Advantage: 68

Changchun BC＆HC Pharmaceutical Technology Co.,Ltd

Tel: 0431-0431-80871588 15804318257
Fax: 0431-88417879
Email: 3468242165@qq.com
Country: China
ProdList: 194
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Chengdu Saiousi Pharmaceutical Co., Ltd

Tel: 028-64971018 18108168130
Fax: 86 028-64971018
Country: China
ProdList: 1781
Advantage: 55

9ding chemical ( Shanghai) Limited

Tel: 021-021-52271985 17721149837
Fax: +86 (21) 52271987
Email: sales@9dingchem.com
Country: China
ProdList: 19800
Advantage: 60

Shanghai BaiShun Biological Technology Co., Ltd

Tel: 021-37581181
Fax: 021-57456066
Email: sales@chem-mall.com
Country: China
ProdList: 10330
Advantage: 58

Conier Chem & Pharma Limited

Tel: 13368167990
Email: sales@conier.com
Country: China
ProdList: 2830
Advantage: 58

Wuhan FengyaoTonghui Chemical Products Co., Ltd.

Tel: 027-87466105 15377573527
Email: 2678564200@qq.com
Country: China
ProdList: 17987
Advantage: 58

Shanghai He Huan Chemical Co., Ltd.

Tel: 021-60345187 13917602471
Fax: 021-60345187
Email: lzz841106@aliyun.com
Country: China
ProdList: 9897
Advantage: 58

Shanghai Hongye Biotechnology Co. Ltd

Tel: 400-9205774
Email: sales@glpbio.cn
Country: China
ProdList: 6777
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57412
Advantage: 58

Shenzhen Botel Biotechnology Co. Ltd.

Tel: 0755-22202135 13316968096
Email: 1979313431@qq.com
Country: China
ProdList: 8895
Advantage: 58

sgtlifesciences pvt ltd

Tel: +8617013299288
Email: dj@sgtlifesciences.com
Country: China
ProdList: 12373
Advantage: 58

Dayang Chem (Hangzhou) Co.,Ltd.

Tel: 571-88938639 +8617705817739
Fax: +86-571-88938652，+86-571- 88492614
Email: info@dycnchem.com
Country: China
ProdList: 52849
Advantage: 58

Hefei Hirisun Pharmatech Co., Ltd

Tel: +8615056975894
Fax: 86-0551-62678551
Email: shawn@hirisunpharm.com
Country: CHINA
ProdList: 9911
Advantage: 58

AFINE CHEMICALS LIMITED

Tel: +86-0571-85134551
Fax: 008657185134895
Email: sales@afinechem.com
Country: China
ProdList: 15352
Advantage: 58

Guangzhou Dreampharm Biotechnology Co., Ltd.

Tel: 020-36607679 17825480238
Fax: QQ 3008233717
Email: 3008233717@qq.com
Country: China
ProdList: 9919
Advantage: 12

Jinan blalong chemical co. LTD

Tel: 2710913286@.com
Email: 1513643261@qq.com
Country: China
ProdList: 14246
Advantage: 58

Shanghai Yanze Chemical Co., Ltd.

Tel: 021-13773155751 19975051755
Email: 260924549@qq.com
Country: China
ProdList: 8904
Advantage: 58

Hefei fuya biotechnology co. LTD

Tel: 18096409024
Email: sales02@foreversyn.com
Country: China
ProdList: 1917
Advantage: 58

CONIER CHEM AND PHARMA LIMITED

Tel: +8618523575427
Email: sales@conier.com
Country: China
ProdList: 49374
Advantage: 58

career henan chemical co

Tel: +86-0371-86658258 +8613203830695
Fax: 0086-371-86658258
Email: factory@coreychem.com
Country: China
ProdList: 29811
Advantage: 58

SHENZHEN PHYSTANDARD BIO-TECH CO.,LTD

Tel: 0755-0755-0755-83725350 13380397412
Fax: 0755-28094224
Email: 3001280422@qq.com
Country: China
ProdList: 10005
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 025-85560043 13675144456
Fax: 025-85563444
Email: sean.lv@synzest.com
Country: China
ProdList: 11438
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44918
Advantage: 58

Guangzhou Juntang Technology Co., Ltd

Tel: 020-36607679 13502246435
Email: sales@dmstandards.com
Country: China
ProdList: 10945
Advantage: 58

Shanghai Sunway Pharmaceutical Technology Co.,Ltd.

Tel: 021-51816796-820 13611835272
Fax: 021-5161 3951
Email: sales2@sunwaypharm.com
Country: China
ProdList: 44458
Advantage: 58

Hubei Guangao Biotechnology Co., Ltd

Tel: 027-027-59223056 18162699093
Fax: 027-59223056
Email: 1208480011@qq.com
Country: China
ProdList: 9924
Advantage: 58

Tianmen Hengchang Chemical Co., Ltd

Tel: 027-59322316 15172518801
Fax: 027-59322316
Email: 1208480077@qq.com
Country: China
ProdList: 9882
Advantage: 58

Hubei xingongli Chemical Co., Ltd

Tel: 027-59106151 15172325309
Fax: 027-59503710
Email: 1400858877@qq.com
Country: China
ProdList: 9937
Advantage: 58

Guangzhou Yunmen Biotechnology Co., Ltd

Tel: 18902340307 18902340307
Fax: 0751-2819901
Email: 3356812514@qq.com
Country: China
ProdList: 9245
Advantage: 58

Changzhou Xianglong Pharmaceutical Technology Co., LTD

Tel: 18661161657
Email: yaoxiangqiu2021@163.com
Country: China
ProdList: 9996
Advantage: 58

Shanghai Universal Biotech Co.,Ltd

Tel: 13774214275
Email: zhouzz@univ-bio.com
Country: China
ProdList: 24990
Advantage: 58

QUALITY CONTROL SOLUTIONS LTD.

Tel: 0755-66853366; 13670046396
Email: ORDERS@QCSRM.COM
Country: China
ProdList: 24326
Advantage: 58

Hubei Kele Fine Chemical Co., Ltd

Tel: 027-59101668 19945030958
Fax: 027-59101668
Email: 2881924765@qq.com
Country: China
ProdList: 8099
Advantage: 58

Wuhan Augda Biotechnology Co., Ltd

Tel: 15071299552
Fax: QQ:262933239
Email: 262933239@qq.com
Country: China
ProdList: 6886
Advantage: 58

Less

View Lastest Price from Latanoprost acid manufacturers

Career Henan Chemical Co

Product: Latanoprost acid 41639-83-2
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-02-16

41639-83-2, Latanoprost acidRelated Search:

Latanoprost Epoxide (Mixture of isoMers) Latanoprost Tris(triethylsilyl) Ether NCX 116 15-KETO LATANOPROST (5Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-(3-oxo-5-phenylpentyl)cyclopentyl]-5-heptenoic Acid 15(S)-Latanoprost Latanoprost Lactone Diol trans Latanoprost CHLOROPHOSPHONAZO III Prostaglandin E2 Latanoprost Citric acid Ethyl 2-(Chlorosulfonyl)acetate Prostaglandin E1 Folic acid Ascoric Acid Latanoprost Impurity 1 Latanoprost Impurity (Diphenylphosphine Isopropyl Ester)

LATANOPROST (FREE ACID)

LAT-FA

17-PHENYL-13,14-DIHYDRO TRINOR PROSTAGLANDIN F2ALPHA

(5Z,9ALPHA,11ALPHA,15R)-9,11,15-TRIHYDROXY-17-PHENYL-18,19,20-TRINOR-PROST-5-EN-1-OIC ACID

9ALPHA, 11ALPHA, 15R-TRIHYDROXY-17-PHENYL-18,19,20-TRINOR-PROST-5Z-EN-1-OIC ACID

PHXA 85

PhXA 85, (5Z,9α,11α,15R)-9,11,15-Trihydroxy-17-phenyl-18,19,20-trinor-prost-5-en-1-oic acid

Latanoprost acid,(5Z,9α,11α,15R)-9,11,15-Trihydroxy-17-phenyl-18,19,20-trinor-prost-5-en-1-oic acid, PhXA 85

LT-ACID(LATANOPROST ACID)

LT-Acid

(5z,9α,11α,15r)-9,11,15-trihydroxy-17-phenyl-18,19,20-trinor-prost-5-en-1-oic acid

(Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoic acid

LATANOPROST ACID

(5Z)-

Latanoprost Related CoMpound E

Latanoprost Related Compound E (25 mg) ((Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl}-5-heptenoic acid)

(Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl}-5-heptenoic acid

LT-Acid(Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoic acid

LATANOPROSTACID;PHXA 85

(Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((R)-3-hydroxy-5-phenylpentyl)cyclopentyl)hept-5-enoic acid

Latanoprost Impurity 8（Latanoprost Acid）

Latanoprost Acid/(Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoic acid

5-Heptenoic acid, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]-, (5Z)-

latanoprostfreeaci

Latanoprost Related Compound E ((Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl (1357533)

Latanoprost Impurity 23

Latanoprost EP Impurity H

Latanoprost EP Impurity H (Latanoprost USP Related Compound E)

Latanoprost Acid / Latanoprost Related Compound-E

Latanoprost acid (related compound E)

(5Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]-5-heptenoic acid

41639-83-2

7130209-82-4

C26H40O5

C23H35O5

Aromatics, Chiral Reagents, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals

Aromatics

Chiral Reagents

Intermediates & Fine Chemicals

Metabolites & Impurities

Pharmaceuticals