Tocofersolan

ChemicalBook > CAS DataBase List > Tocofersolan

Product Name: Tocofersolan
CAS No.: 9002-96-4
Chemical Name: Tocofersolan
Synonyms: tpgs;VITAMIN E TPGS;Vitamin E polyethylene glycol succinate;d-alpha-tocopheryl polyethylene glycol succinate;Tocophersolan;D-α-Tocopherol polyethylene glycol succinate;tocopherosolan;D-a-Tocopherol Polyethylene Glycol Succinate;d-alpha-tocopherylpoly(ethyleneglycol)1000succinate;D-a-Tocopherol Polyethylene Glycol Succinate (Vitamin E TPGS)
CBNumber: CB8396198
Molecular Formula: (C2H4O)nC33H54O5
Formula Weight: 0
MOL File: 9002-96-4.mol

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Tocofersolan Property

Melting point:: 34-38°C
storage temp.: 2-8°C
solubility: H2O: soluble1g/10 mL, clear to faintly turbid, colorless to faintly yellow
form: Solid
color: White to Pale Yellow Waxy
InChI: InChI=1S/C34H56O6/c1-23(2)12-9-13-24(3)14-10-15-25(4)16-11-20-34(8)21-19-29-28(7)32(26(5)27(6)33(29)40-34)39-31(37)18-17-30(36)38-22-35/h23-25,35H,9-22H2,1-8H3
InChIKey: WFWQYXBTWIHIIW-UHFFFAOYSA-N
SMILES: C(=O)(OC1C(C)=C2CCC(C)(CCCC(CCCC(CCCC(C)C)C)C)OC2=C(C)C=1C)CCC(=O)OCO
LogP: 9.745 (est)

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Safety

WGK Germany: 2
RTECS: TR1581200
HS Code: 2936.28.0000

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 57668
Product name: D-α-Tocopherol polyethylene glycol 1000 succinate
Purity: BioXtra, water soluble vitamin E conjugate
Packaging: 5g
Price: $88.9
Updated: 2024/03/01

Sigma-Aldrich

Product number: 57668
Product name: D-α-Tocopherol polyethylene glycol 1000 succinate
Purity: BioXtra, water soluble vitamin E conjugate
Packaging: 25g
Price: $310
Updated: 2024/03/01

TCI Chemical

Product number: T3118
Product name: α-Tocopherol Polyethylene Glycol Succinate
Packaging: 5G
Price: $70
Updated: 2024/03/01

TCI Chemical

Product number: T3118
Product name: α-Tocopherol Polyethylene Glycol Succinate
Packaging: 25G
Price: $240
Updated: 2024/03/01

Strem Chemicals

Product number: 08-2180
Product name: DL-α-Tocopherol methoxypolyethylene glycol succinate solution (2 wt% in water) TPGS-750-M
Packaging: 10ml
Price: $23
Updated: 2021/12/16

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Tocofersolan Chemical Properties,Usage,Production

Chemical Properties

Vitamin E polyethylene glycol succinate is a synthetic product. It is available as a white to light-brown, waxy solid and is practically tasteless. Chemically, it is a mixture composed principally of monoesterified polyethylene glycol 1000, the diesterified polyethylene glycol 1000, free polyethylene glycol 1000, and free tocopherol.

Uses

tocophersolan is an anti-oxidant, this is a water-soluble form of vitamin e.

Uses

Tocofersolan is a polyethylene glycol derivative of α-Tocopherol (T526125). Tocofersolan is a synthetic water-soluble vitamin E unlike its natural counterpart which are fat soluble. Tocofersolan is used in pediatrics in the treatment vitamin E-deficient cholestatic children. Tocofersolan has potential application as a absorption enhancer in drug delivery systems. Typical batch, n = 21

Production Methods

Vitamin E polyethylene glycol succinate is prepared by esterification of the acid group of crystalline D-a-tocopheryl acid succinate by polyethylene glycol 1000.

Pharmaceutical Applications

Vitamin E polyethylene glycol succinate is an esterified vitamin E (tocopherol) derivative primarily used as a solubilizer or emulsifying agent because of its surfactant properties. Structurally, it is amphipathic and hydrophilic, unlike the tocopherols, and therefore it is a water-soluble derivative that can be used in pharmaceutical formulations such as capsules, tablets, hot-melt extrusion, microemulsions, topical products, and parenterals. One of the most important applications is its use as a vehicle for lipid-based drug delivery formulations. It can also be used as a source of vitamin E.
Vitamin E polyethylene glycol succinate has been characterized with respect to its mechanism of action and studied as a Pglycoprotein inhibitor.

Biochem/physiol Actions

D-α-Tocopherol polyethylene glycol 1000 succinate (TPGS) also known as vitamin E TPGS, is a therapeutic agent for vitamin E deficiency in children, administered during chronic childhood cholestasis. TPGS exerts anti-tumor activity in MCF-7 and breast cancer cells by downregulating anti-apoptotic proteins. TPGS finds its application as an emulsifier in the preparation of poly(lactic-co-glycolic acid) (PLGA) particles for DNA labelling, produces particles of uniform size, high encapsulation efficiency, increases hydrophilicity and prevents aggregation of particles.

Safety

Vitamin E polyethylene glycol succinate has been used at levels of 280 mg/capsule in the product Agenerase (amprenavir), which was dosed at 8 capsules (2240mg vitamin E TPGS) per day. An additional assessment of the safety of vitamin E polyethylene glycol succinate has been published, which includes a report showing no-observed-adverse-effect-level (NOAEL) in rats of 1000 mg/kg/day.

storage

Vitamin E polyethylene glycol succinate is stable at ambient room temperature for up to 4 years. It reacts with alkalis and acids. Aqueous solutions of vitamin E polyethylene glycol succinate are stable over a pH range of 4.5–7.5 and can be further stabilized with propylene glycol.

Incompatibilities

Vitamin E polyethylene glycol succinate is incompatible with strong acids and strong alkalis.

Regulatory Status

GRAS listed. Included in the FDA Inactive Ingredients Database (ophthalmic solution or drops; oral capsules, solution, tablet; topical solution or drops). Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Tocofersolan Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Tocofersolan manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Tocofersolan 9002-96-4
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-04-07

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: Tocofersolan 9002-96-4
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000
Release date: 2024-05-10

Hebei Weibang Biotechnology Co., Ltd

Product: Tocofersolan 9002-96-4
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-11-01

9002-96-4, TocofersolanRelated Search:

Dihydromyrcenol Ethylene glycol Tocopheryl acetate Tetrahydro-4H-pyran-4-one Ethylene glycol diacetate C8E3 Diethylene glycol Polyethylene Diethylstilbestrol 1,4-Butanediol 6alpha-Methylprednisolone sodium succinate Disodium succinate L-Ascorbic acid 6-stearate Pyridoxine Ascorbic Acid 3-O-Ethyl-L-ascorbic acid PROPYLENE GLYCOL 2,3-Dihydro-2,3,4,6,7-pentamethyl-2-(4,8,12-trimethyltridecyl)-5-benzofuranol

DL-A-TOCOPHEROL POLYETHYLENE GLYCOL SUCCINATE

DL-ALPHA-TOCOPHEROL POLYETHYLENE GLYCOL SUCCINATE

d-alpha-tocopheryl polyethylene glycol succinate

alpha-(4-((3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2h-1-benzopyran-6-yl)oxy)-1,4-dioxobutanol poly(ethylene glycol) succinate

tocofersolan

tocopherosolan

2-ethanediyl),.alpha.-[4-[[3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzoPoly(oxy-1

poly(oxy-1,2-ethanediyl),alpha-(4-((3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12

tpgs

Tocophersolan

dl-alpha-Tocopherol Polethylene Glycol Succinate

D-α-Tocopheryl polyethylene glycol succinate

Poly(oxy-1,2-ethanediyl), .alpha.-4-(2R)-3,4-dihydro-2,5,7,8-tetramethyl-2-(4R,8R)-4,8,12-trimethyltridecyl-2H-1-benzopyran-6-yloxy-1,4-dioxobutyl-.omega.-hydroxy-

D-ALPHA-TOCOPHEROLPOLYETHYLENEGLYCOL-1000-SUCCINATE

ALPHA-TOCOPHEROLPOLYETHYLENEGLYCOL1000SUCCINATE

VITAMIN E TPGS

D-α-Tocopherol polyethylene glycol 1000 succinate

D-α-Tocopherol polyethylene glycol succinate, TPGS, Vitamin E polyethylene glycol succinate, Vitamin E-TPGS

Poly(oxy-1,2-ethanediyl), alpha-(4-((3,4-dihydro-2,5,7,8-tetramethyl-2- (4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl)oxy)-1,4-dioxobutyl)-omega-hydroxy-, (2R-(2R*(4R*,8R*)))

D-a-Tocopherol Polyethylene Glycol Succinate (Vitamin E TPGS)

alpha-Tocopheryl poly(ethylene glycol) 1000 succinate, D-

alpha-Tocopheryl poly(ethylene glycol)1000 succinate, D-

Tocofersolan [inn]

D-α-Tocopherol polyethylene glycol succinate

Vitamin E polyethylene glycol succinate

TPGS-VE

D-a-Tocopherol Polyethylene Glycol Succinate

D-Α-Tocopherol Polyethylene Glycol Succinate ( Tpgs )

4-dioxobutyl)-omega-hydroxy--trimethyltridecyl)-2h-1-benzopyran-6-yl)oxy)-

8r*)))-(2r-(2r*(4r

alpha-tocopherylpolyethyleneglycolsuccinate

d-.alpha.-Tocopherylpoly(ethyleneglycol)1000succinate

d1t

d-alpha-tocopherylpoly(ethyleneglycol)1000succinate

Poly(oxy-1,2-ethanediyl),.alpha.-[4-[[3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl]oxy]-1,4-dioxobutyl]-.omega.-hydroxy-,[2R-[2R*(4R*,8R*)]]-

[2R-[2R*(4R*,8R*)]]-α-[4-[[3,4-dihydro-2,5,7,8-tetraMethyl-2-(4,8,12-triMethyltridecyl)-2H-1-benzopyran-6-yl]oxy]-1,4-dioxobutyl]-ω-hydroxypoly(oxy-1,2-ethanediyl)

Mono[2,5,7,8-tetraMethyl-2-(4,8,12-triMethyltridecyl)-6-chroManyl] Succinate Polyoxyethylene Ether

VitaMin E-TPGS ("tocofersolan")

DL-α-Tocopherol methoxypolyethylene glycol succinate solution (2 wt% in water) TPGS-750-M

Tocofersolan(TPGS)

Vitamin E Polyethylene Glycol Succinate (TPGS)

Poly(oxy-1,2-ethanediyl),a-[4-[[(2R)-3,4-dihydro-2,5,7,8-tetraMethyl-2-[(4R,8R)-4,8,12-triMethyltridecyl]-2H-1-benzopyran-6-yl]oxy]-1,4-dioxobutyl]-w-hydroxy-

Tocopheryl PEG succinate

d-α-tocopheryl polyethylene glycol succinic acid esters (of TPGS)

Tocofersolan,VE-TPGS

D-ALPHA-TOCOPHEROL POLYETHYLENE GLYC

alpha-Tocopherol Polyethylene Glycol Succinate

Tocofersolan9002-96-4

D-2-Vitamin E polyethylene glycol succinate

D-alpha-Tocopherol polyethylene glycol

Factory Supply Vitamin E Polyethylene Glycol Succinate CAS 9002-96-4

Polyethylene glycol 1000Q: What is Polyethylene glycol 1000 Q: What is the CAS Number of Polyethylene glycol 1000 Q: What is the storage condition of Polyethylene glycol 1000 Q: What are the applications of Polyethylene glycol 1000

Vitamin E Tocofersolan

α-Tocopherol Polyethylene Glycol Succinate

Tuoke suolun

α-Tocopheryl polyethylene glycol succinate

Vitamin E Polyethylene Glycol Succinate (TPGS) /Tocofersolan

Vitamin E succinic acid polyethylene glycol ester