5-PHENYL-2H-PYRAZOLE-3-CARBOXYLIC ACID ETHYL ESTER
- Product Name
- 5-PHENYL-2H-PYRAZOLE-3-CARBOXYLIC ACID ETHYL ESTER
- CAS No.
- 13599-12-7
- Chemical Name
- 5-PHENYL-2H-PYRAZOLE-3-CARBOXYLIC ACID ETHYL ESTER
- Synonyms
- SALOR-INT L250031-1EA;Ethyl 3-phenyl-5-pyrazole formate;3-phenypyrazole-5-ethyl carboxylate;Ethyl 3-phenylpyrazole-5-carboxylate;ETHYL 3-PHENYL-1H-PYRAZOLE-5-CARBOXYLATE;5-PHENYL-2H-PYRAZOLE-3-CARBOXYLIC ACID ETHYL ESTER;5-phenyl-1(2)H-pyrazole-3-carboxylic acid ethyl ester;1H-pyrazole-5-carboxylic acid, 3-phenyl-, ethyl ester
- CBNumber
- CB8400284
- Molecular Formula
- C12H12N2O2
- Formula Weight
- 216.24
- MOL File
- Mol file
5-PHENYL-2H-PYRAZOLE-3-CARBOXYLIC ACID ETHYL ESTER Property
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- Appearance
- Off-white to light yellow Solid
Safety
- Safety Statements
- 24/25
- HazardClass
- IRRITANT
- HS Code
- 29331990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- E926115
- Product name
- Ethyl3-phenylpyrazole-5-carboxylate
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- COR0003959
- Product name
- ETHYL 3-PHENYL-1H-PYRAZOLE-5-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $221.55
- Updated
- 2021/12/16
- Product number
- 6410AA
- Product name
- Ethyl3-phenyl-1H-pyrazole-5-carboxylate
- Packaging
- 25g
- Price
- $342
- Updated
- 2021/12/16
- Product number
- COR0003959
- Product name
- ETHYL 3-PHENYL-1H-PYRAZOLE-5-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $1316.7
- Updated
- 2021/12/16
- Product number
- COR0003959
- Product name
- ETHYL 3-PHENYL-1H-PYRAZOLE-5-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 10G
- Price
- $1905.75
- Updated
- 2021/12/16
5-PHENYL-2H-PYRAZOLE-3-CARBOXYLIC ACID ETHYL ESTER Chemical Properties,Usage,Production
Chemical Properties
White solid
Synthesis
98-86-2
95-92-1
13599-12-7
A mixed solution of acetophenone (100 g) with diethyl oxalate (123 g) was added slowly and dropwise to a mixed system of potassium tert-butoxide (132 g) and tetrahydrofuran (600 mL), and the reaction was stirred at room temperature for 15 hours. Subsequently, acetic acid (119 mL) and hydrazine monohydrate (45.8 g) were added to the reaction system and stirred at reflux for 2 hours. After completion of the reaction, the reaction solution was cooled to room temperature and concentrated under reduced pressure. The concentrated residue was dissolved in a solvent mixture of water and ethyl acetate for partition extraction. The ethyl acetate layer was separated, washed sequentially with saturated aqueous sodium carbonate and saturated saline, dried over anhydrous magnesium sulfate and concentrated. The resulting crude product was recrystallized by diisopropyl ether to give ethyl 3-phenyl-1H-pyrazole-5-carboxylate (145 g, yield: brown solid). The product was characterized by 1H-NMR (300 MHz, CDCl3): δ 1.36 (3H, t, J = 7.2 Hz), 4.36 (2H, q, J = 7.2 Hz), 7.10 (1H, s), 7.30-7.46 (3H, m), 7.71-7.80 (2H, m), 11.86 (1H, br s).
References
[1] Patent: WO2007/18314, 2007, A2. Location in patent: Page/Page column 115
5-PHENYL-2H-PYRAZOLE-3-CARBOXYLIC ACID ETHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
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