N-NITROSODIETHANOLAMINE Property

Melting point:

200 °C (decomp)

Boiling point:

bp0.01 125°

Density 

1,26 g/cm³

refractive index 

nD20 1.4849

Flash point:

11℃

storage temp. 

2-8°C

Water Solubility 

Completely miscible in water

solubility 

DMSO (Soluble), Ethyl Acetate (Sparingly), Methanol (Soluble), Water (Sparingly)

form 

clear liquid to slightly cloudy liquid

pka

13.76±0.10(Predicted)

color 

Light yellow to Brown

Merck 

14,6634

BRN 

1762620

CAS DataBase Reference

1116-54-7(CAS DataBase Reference)

IARC

2B (Vol. 17, Sup 7, 77) 2000

EPA Substance Registry System

N-Nitrosodiethanolamine (1116-54-7)

Safety

Hazard Codes 

T,F

Risk Statements 

45-11

Safety Statements 

53-45-16

RIDADR 

UN 1993 3/PG 2

WGK Germany 

1

RTECS 

KL9550000

HS Code 

2922.19.9690

HazardClass 

3.1

PackingGroup 

II

Hazardous Substances Data

1116-54-7(Hazardous Substances Data)

Toxicity

LD50 orl-rat: 7500 mg/kg GISAAA 40(1),81,75

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

H350May cause cancer

Precautionary statements

P201Obtain special instructions before use.

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

N-NITROSODIETHANOLAMINE Chemical Properties,Usage,Production

Chemical Properties

Reddish Yellow Oil

Uses

A potent liver carcinogen in several species of animals, is one of the most widespread N-nitroso compounds in the human environment.

Definition

ChEBI: N-Nitrosodiethanolamine is a nitroso compound.

General Description

Yellow to dark brown very viscous liquid with no distinct odor.

Air & Water Reactions

Water soluble.

Reactivity Profile

N-NITROSODIETHANOLAMINE can react with alkoxides. N-NITROSODIETHANOLAMINE reacts with sulfuric acid at temperatures above 311° F.

Health Hazard

ACUTE/CHRONIC HAZARDS: N-NITROSODIETHANOLAMINE may be harmful by eye or skin contact, inhalation or ingestion. It is an irritant and, when heated to decomposition, it emits toxic fumes of carbon monoxide, carbon dioxide and nitrogen oxides.

Fire Hazard

Flash point data for N-NITROSODIETHANOLAMINE are not available; however, N-NITROSODIETHANOLAMINE is probably combustible.

Safety Profile

Confirmed carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data.Mildly toxic by ingestion. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also N-NITROSO COMPOUNDS and ALCOHOLS.

Carcinogenicity

N-Nitrosodiethanolamine is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.

Purification Methods

Purify NDELA by dissolving the amine (0.5g) in 1-propanol (10mL) and 5g of anhydrous Na2SO4 added with stirring. After standing for 1-2hours, it is filtered and passed through a chromatographic column packed with 10mL of AG 50W x 8 (H+form 50-100mesh, a strongly acidic cation exchanger). The eluent and washings (50 mL EtOH) are combined and evaporated to dryness at 35o. It has also been extracted with EtOH from the nitrosation mixture of ethanolamine, filtered and distilled under high vacuum. [Fukuda et al. Anal Chem 53 2000 1981, Jones & Wilson J Chem Soc 550, 1949, Beilstein 1 III 721, see Spiegelhalder et al. N-Nitroso Compounds: Occurrence Biological Effects and Relevance in Human Cancer (eds. O’Neill et al. IARC Scientific Publications No 57; IARC Lyon p943 1984.] Possible