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N-NITROSODIETHANOLAMINE

Product Name
N-NITROSODIETHANOLAMINE
CAS No.
1116-54-7
Chemical Name
N-NITROSODIETHANOLAMINE
Synonyms
ndela;nci-c55583;rcrawastenumberu173;diaethanolnitrosamin;DIETHANOLNITROSAMINE;Trolamine Impurity C;diethanolnitrosoamine;nitrosodiethanolamine;nitrosoiminodiethanol;N-DIETHANOLNITROSAMINE
CBNumber
CB8401443
Molecular Formula
C4H10N2O3
Formula Weight
134.13
MOL File
1116-54-7.mol
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N-NITROSODIETHANOLAMINE Property

Melting point:
200 °C (decomp)
Boiling point:
bp0.01 125°
Density 
1,26 g/cm3
refractive index 
nD20 1.4849
Flash point:
11℃
storage temp. 
2-8°C
Water Solubility 
Completely miscible in water
solubility 
DMSO (Soluble), Ethyl Acetate (Sparingly), Methanol (Soluble), Water (Sparingly)
form 
clear liquid to slightly cloudy liquid
pka
13.76±0.10(Predicted)
color 
Light yellow to Brown
Merck 
14,6634
BRN 
1762620
CAS DataBase Reference
1116-54-7(CAS DataBase Reference)
IARC
2B (Vol. 17, Sup 7, 77) 2000
EPA Substance Registry System
N-Nitrosodiethanolamine (1116-54-7)
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Safety

Hazard Codes 
T,F
Risk Statements 
45-11
Safety Statements 
53-45-16
RIDADR 
UN 1993 3/PG 2
WGK Germany 
1
RTECS 
KL9550000
HS Code 
2922.19.9690
HazardClass 
3.1
PackingGroup 
II
Hazardous Substances Data
1116-54-7(Hazardous Substances Data)
Toxicity
LD50 orl-rat: 7500 mg/kg GISAAA 40(1),81,75
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

H350May cause cancer

Precautionary statements

P201Obtain special instructions before use.

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
N7632
Product name
N-Nitrosodiethanolamine
Packaging
1g
Price
$84.4
Updated
2024/03/01
Sigma-Aldrich
Product number
N7632
Product name
N-Nitrosodiethanolamine
Packaging
500mg
Price
$113
Updated
2024/03/01
TCI Chemical
Product number
N0438
Product name
N-Nitrosodiethanolamine
Purity
>97.0%(GC)
Packaging
5g
Price
$288
Updated
2024/03/01
TCI Chemical
Product number
N0438
Product name
N-Nitrosodiethanolamine
Purity
>97.0%(GC)
Packaging
25g
Price
$716
Updated
2024/03/01
TRC
Product number
N525200
Product name
Nitrosobis(2-hydroxyethyl)amine
Packaging
100mg
Price
$45
Updated
2021/12/16
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N-NITROSODIETHANOLAMINE Chemical Properties,Usage,Production

Chemical Properties

Reddish Yellow Oil

Uses

A potent liver carcinogen in several species of animals, is one of the most widespread N-nitroso compounds in the human environment.

Definition

ChEBI: N-Nitrosodiethanolamine is a nitroso compound.

General Description

Yellow to dark brown very viscous liquid with no distinct odor.

Air & Water Reactions

Water soluble.

Reactivity Profile

N-NITROSODIETHANOLAMINE can react with alkoxides. N-NITROSODIETHANOLAMINE reacts with sulfuric acid at temperatures above 311° F.

Health Hazard

ACUTE/CHRONIC HAZARDS: N-NITROSODIETHANOLAMINE may be harmful by eye or skin contact, inhalation or ingestion. It is an irritant and, when heated to decomposition, it emits toxic fumes of carbon monoxide, carbon dioxide and nitrogen oxides.

Fire Hazard

Flash point data for N-NITROSODIETHANOLAMINE are not available; however, N-NITROSODIETHANOLAMINE is probably combustible.

Safety Profile

Confirmed carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data.Mildly toxic by ingestion. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also N-NITROSO COMPOUNDS and ALCOHOLS.

Carcinogenicity

N-Nitrosodiethanolamine is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.

Purification Methods

Purify NDELA by dissolving the amine (0.5g) in 1-propanol (10mL) and 5g of anhydrous Na2SO4 added with stirring. After standing for 1-2hours, it is filtered and passed through a chromatographic column packed with 10mL of AG 50W x 8 (H+form 50-100mesh, a strongly acidic cation exchanger). The eluent and washings (50 mL EtOH) are combined and evaporated to dryness at 35o. It has also been extracted with EtOH from the nitrosation mixture of ethanolamine, filtered and distilled under high vacuum. [Fukuda et al. Anal Chem 53 2000 1981, Jones & Wilson J Chem Soc 550, 1949, Beilstein 1 III 721, see Spiegelhalder et al. N-Nitroso Compounds: Occurrence Biological Effects and Relevance in Human Cancer (eds. O’Neill et al. IARC Scientific Publications No 57; IARC Lyon p943 1984.] Possible

N-NITROSODIETHANOLAMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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N-NITROSODIETHANOLAMINE Suppliers

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1116-54-7, N-NITROSODIETHANOLAMINERelated Search:

N-NITROSODIETHYLAMINE N-NITROSODIETHANOLAMINE SOLUTION 100UG/ML IN METHANOL 5X1ML N-NITROSODIETHANOLAMINE SOLUTION 100UG/ML IN METHANOL 5ML N-NITROSODIETHANOLAMINE SOLUTION 100UG/ML IN METHANOL 1ML N-Nitrosodiethanolamine-d8 Hydrochloride N-NITROSODIETHANOLAMINE N-nitroso-2-methoxy-2,6-dimethylmorpholine N-nitrosoiminodiacetic acid N-NITROSOBIS(ACETOXYETHYL)AMINE 4-NITROSO-MORPHOLINE-3-CARBOXYLIC ACID NITROSOBIS(2-HYDROXYETHYL)-D8-AMINE N-nitroso-2-hydroxymorpholine DIISOPROPANOLNITROSAMINE N-nitrosobis(2-acetoxypropyl)amine

  • 2,2’-nitrosiminodi-ethano
  • bis-(2-hydroxy-ethyl)-nitroso-amine
  • bis(beta-hydroxyaethyl)nitrosamin
  • bis(beta-hydroxyethyl)nitrosamine
  • bis-2-hydroxy-ethyl-nitroso-amine
  • di-(2-hydroxyethyl)-nitrosamine
  • diaethanolnitrosamin
  • diethanolnitrosoamine
  • n,n-diethanolnitrosamine
  • nci-c55583
  • ndela
  • nitrosodiethanolamine
  • nitrosoiminodiethanol
  • n-nitrosoaminodiethanol
  • n-nitrosobis(2-hydroxyethyl)amine
  • n-Nitroso-bis(2-hydroxymethyl)-amine
  • n-nitrosodiaethanolamin
  • n-nitrosoiminodi-ethano
  • 2,2'-dihydroxy-N-nitrosodiethylamine
  • 2,2'-nitrosiminodiethanol
  • N-Nitrosodiethanolamine? N-nitrosoiminodiethanol
  • Ethanol, 2,2-(nitrosoimino)bis-
  • N-DIETHANOLNITROSAMINE
  • ETHANOL,N-NITROSOIMINODI-
  • bis(beta-hydroxyaethyl)nitrosamin (german)
  • diaethanolnitrosamin (german)
  • rcrawastenumberu173
  • N-NITROSODIETHANOLAMINE
  • DIETHANOLNITROSAMINE
  • 2,2'-(Nitrosoimino)diethanol
  • N,N-bis(2-hydroxyethyl)nitrous amide
  • Nitrosobis(2-hydroxyethyl)amine
  • Bis(2-hydroxyethyl)nitrosamine
  • <i>N</i>-Nitrosodiethanolamine
  • 2,2’-(nitrosoimino)bis-ethano
  • 2,2’-dihydroxy-n-nitroso-diethylamin
  • 2,2’-iminodi-n-nitrosoethanol
  • 2,2’-(nitrosoimino)bisethanol
  • 2,2’-(nitrosoimino)bis-Ethanol
  • N-Nitrosodiethanolamine&gt
  • N-Nitroso-diethanolamine Solution in Methanol, 1000μg/mL
  • N-Nitrosoamindiethanol
  • 2-[(2-hydroxyethyl)(nitroso)amino]ethan-1-ol
  • 2,2′-(nitrosoimino)diethanol (N-nitrosodiethanolamine)
  • Trolamine EP Impurity C
  • Trolamine Impurity C
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