Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid

Physical Form

Product Name: Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid
CAS No.: 486460-00-8
Chemical Name: Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid
Synonyms: Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid;(R)-N-Boc-3-AMino-4-(2,4,5-trifluorophenyl)butanoic acid;(R)-3-((tert-Butoxycarbonyl)aMino)-4-(2,4,5-trifluorophenyl)butanoic acid;(R)-3-(Tert-Butoxycarbonyl)-4-(2,4,5-Trifluorophenyl)Butanoic Acid;(3R)-N-Boc-3-amin;BOC- Butanoic Acid;Parecoxib SodiuM API;BOC-(R)-3-AMINO-4-(2;Sitagliptin Impurity 78;Sitagliptin Impurity 19
CBNumber: CB8402112
Molecular Formula: C15H18F3NO4
Formula Weight: 333.31
MOL File: 486460-00-8.mol

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Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid Property

Melting point:: 136-138℃
Boiling point:: 443.1±45.0 °C(Predicted)
Density: 1.292±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form: Solid
pka: 4.30±0.10(Predicted)
color: White to Off-White

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Safety

HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H319Causes serious eye irritation
Precautionary statements: P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B692330
Product name: (R)-3-((tert-Butoxycarbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoicAcid
Packaging: 1g
Price: $135
Updated: 2021/12/16

AK Scientific

Product number: X1035
Product name: Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoicacid
Packaging: 25g
Price: $147
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB29150
Product name: Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid
Packaging: 100g
Price: $200
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB29150
Product name: Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid
Packaging: 250g
Price: $400
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB29150
Product name: Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid
Packaging: 10g
Price: $40
Updated: 2021/12/16

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Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid Chemical Properties,Usage,Production

Physical Form

White to Yellow Solid

Description

Boc-(R) -3-amino-4 -(2,4, 5-trifluorophenyl) butyric acid is an important intermediate for the preparation of sitagliptin. Sitagliptinphosphate is the first dipeptidase -IV(dpp-4) inhibitor approved by FDA in 2006. It is used for the treatment of type II diabetes mellitus. It has obvious hypoglycemic effect when used alone or in combination with metformin and pioglitazone, and it is safe to take, well tolerated, with few adverse reactions.

Uses

(R)-3-((tert-Butoxycarbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoic Acid has been used as a reactant for the preparation of dipeptidyl peptidase-4 (DPP4) inhibitors for the treatment of type 2 diabetes, such as sitagliptin.

Synthesis

(R)-β-tert-butoxycarbonylamino-2,4,5-trifluorophenylbutyric acid ethyl ester could used as a starting material and followed by adding Methanol and LiOHH2O as reaction reagents. Adding dichloromethane to the concentrate and adjust the pH to 2 with 2N HCl. Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid could be obtained through further purification.

Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid Suppliers

China 373 China Hong Kong 1 Germany 1 India 17 Japan 2 United Kingdom 1 United States 21 Global 416

Chiral Quest (Suzhou) Co., Ltd.

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Shanghai Scientia Pharmaceutical Technology Co., Ltd.

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Suzhou haiyu Biochem Industrial Co., LTD

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View Lastest Price from Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid manufacturers

Sinoway Industrial co., ltd.

Product: Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid 486460-00-8
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98% up by HPLC
Supply Ability: 20tons
Release date: 2024-04-16

Wuhan Circle Star Chem-medical Technology Co.,Ltd

Product: Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid 486460-00-8
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98
Supply Ability: 1000
Release date: 2025-01-07

Nanjing Fred Technology Co., Ltd

Product: Boc-(R)-3-amino-4-(2,4,5-trifluorophenyl)-butyric acid 486460-00-8
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1 ton
Release date: 2024-01-02

486460-00-8, Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acidRelated Search:

2-Deoxy-L-ribose Sebacic acid Butyraldehyde ETHYLENE OXIDE BOC-(S)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID BOC-(R)-3-AMINO-4-(3-FLUORO-PHENYL)-BUTYRIC ACID (R)-3-Amino-4-(2,4,5-trifluorophenyl)butyric acid BOC-(R)-3-AMINO-4-(4-FLUORO-PHENYL)-BUTYRIC ACID BOC-(R)-3-AMINO-4-(3,4-DIFLUORO-PHENYL)-BUTYRIC ACID Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate BOC-(R)-3-AMINO-4-(2-FLUORO-PHENYL)-BUTYRIC ACID Sitagliptin Benzenebutanoicacid,b-[[(1,1-diMethylethoxy)carbonyl]aMino]-2,4,5-trifluoro-,Methylester,(bR)- (R)-methyl 3-acetamido-4-(2,4,5-trifluorophenyl)butanoate 2,4,5-TRIFLUOROBENZYL CHLORIDE Sitagliptin Impurity 34 2-CHLOROMETHYL-5-TRIFLUOROMETHYL-[1,3,4]OXADIAZOLE ethyl 3-oxo-4-(2,4,5-trifluorophenyl)butanoate

Benzenebutanoicacid,b-[[(1,1-diMethylethoxy)carbonyl]aMino]-2,4,5-trifluoro-,(bR)-

(R)-Sitagliptin N-Boc-Acid IMpurity

Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid (3R)-N-(tert-Butoxycarbonyl)-3-amino-4-(2,4,5-trifluorophenyl)butanoic acid

Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid, >=99%

(3R)-N-Boc-3-amino-4-(2,4,5-trifluorophenyl)butanoic acid

(3R)-N-(tert-Butoxycarbonyl)-3-aMino-4-(2,4,5-trifluorophenyl)-butanoic acid- Boc-(R)-3-AMino-4-(2,4,5-trifluorophenyl) butanoic acid (BOC acid)

[[(1,1-diMethylethoxy)carbonyl]aMino]-2,4,5-trifluoro-(R)-benzenebuta

BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID

(3R)-N-(TERT-BUTOXYCARBONYL)-3-AMINO-4-(2,4,5-TRIFLUOROPHENYL)BUTANOIC ACID

(3R)-3-{[(tert-butoxy)carbonyl]amino}-4-(2,4,5-trifluorophenyl)butanoic acid

Sitagliptin impurity 19/(R)-Sitagliptin N-Boc-Acid Impurity/(R)-3-((tert-butoxycarbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoic acid

Sitagliptin Impurity 19 ((R)-Sitagliptin N-Boc-Acid Impurity)

Sitagliptin Acid Boc Impurity (Impurity A)

BOC- Butanoic Acid

BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENY

Sitagliptin Impurity 78

Sitagliptin N-BOC Carboxylic acid Impurity

Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid

(R)-Boc-3-Amino-4-(2,4,5-trifluorophenyl)butanoicacid

Sitagliptin Intermediate 1

[[(1,1-dimethylethoxy)carbonyl]amino]-2,4,5-trifluoro-(R)-benzenebutanoic acid

(3R)-N-(TERT-BUTOXYCARBONYL)-3-AMINO-4-(2,4,5-TRIFLUOROPHENYL)BU

3(R)-tert-ButoxycarbonylaMino-4-(2,4,5-trifluoro-phenyl)-butyric acid

(3R)-3-(1,1-Dimethylethoxy carbonyl) amino]- 4-(2,4,5-trifluorophenyl) butanoic acid

Sitagliptin interMediate

(R)-N-Boc-3-AMino-4-(2,4,5-trifluorophenyl)butanoic&nbsp

(R)-N-Boc-3-AMino-4-(2,4,5-trifluorophenyl)butanoic acid

(R)-3-((tert-Butoxycarbonyl)aMino)-4-(2,4,5-trifluorophenyl)butanoic acid

(3R)-3-((1,1-DIMETHYLETHOXYCARBONYL)AMINO)-4-(2,4,5-TRIFLUROPHENYL)-BUTANOIC ACID

(R)-3-(Boc-aMino)-4-(2,4,5-trifluorophenyl)butanoic acid

4-(6-{[(tert-butoxy)carbonyl]aMino}-1,2,5-trifluorocyclohexa-2,4-dien-1-yl)butanoic acid

Parecoxib SodiuM API

Sitagliptin interMediateB

(R)-3-(Tert-Butoxycarbonyl)-4-(2,4,5-Trifluorophenyl)Butanoic Acid

(Tert-Butoxy)Carbonyl (R)-3-Amino-4-(2,4,5-trifluoro-phenyl)-butyric acid

Sitagliptin Impurity 19

(3R)-N-Boc-3-amin

(3R)-N-(tert-Butoxycarbonyl)-3-amino-4-(2,4,5-trifluoro phenyl)butanoic acid [Sita Acid]

Sitagliptin N-BOC Carboxylic Acid

Benzenebutanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-2,4,5-trifluoro-, (βR)-

Boc-(R)-3-Amino-4-(2,4,5-Trifluoro-Phenyl)-ButyricAci

SITAGLIPTIN CAS 654671-78-0 INTERMEDIATES

BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID ISO 9001：2015 REACH

Sitagliptin EP Impurity 15

5-TRIFLUORO-PHENYL)-BUTYRIC ACID

BOC-(R)-3-AMINO-4-(2

N-Boc Sitagliptin Acid Impurity

Sitagliptin Imp-1(sitagliptin Impurity-A)

[[(1,1-dimethylethoxy)carbonyl]amino]-2,4,5-trifluoro-(R)-be...

Boc-(R)-3-Amino-4-(2,4,5-Trifluorophenyl)Butanoic Acid / Sitagliptin Intermediate

(βR)-β-[[(1,1-Dimethylethoxy)carbonyl]amino]-2,4,5-trifluorobenzenebutanoic acid

Boc-(R)-3-Amino-4-(2,4,5-Trifluoro-Phenyl)-Butyric Acid (Boc acid)

Benzenebutanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-2,4,5-trifluoro-, (βR)-

(3R) - N - (tert butoxycarbonyl) -3-amino-4- (2,4,5-trifluorophenyl) butyric acid

BOC-(R-)3-Amino-4(2,4,5-triflurophenyl)Butanoic acid

Boc-(R)-3-Amino-4-(2,4,5-trifluorphenyl)butanoic acid

4-(2,4-difluorophenyl)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butane-1,3-dione

Sitagliptin Impurity 19 (R)-3-((tert-butoxycarbonyl)amino)-4-(2,4,5- trifluorophenyl)butanoic acid