Bleomycin sulfate

ChemicalBook > CAS DataBase List > Bleomycin sulfate

Product Name: Bleomycin sulfate
CAS No.: 9041-93-4
Chemical Name: Bleomycin sulfate
Synonyms: BLEOMYCIN SULPHATE;BLENOXANE;Bleomycin Sulfate (mixture);BLEOMYCIN SULFATE CELL CULTURE TESTED;BLEO;BLEXANE;Bleolem;BLEOcell;BLEO cell;BLEO-cell
CBNumber: CB8412175
Molecular Formula: C110H168N34O46S7
Formula Weight: 2927.17
MOL File: 9041-93-4.mol

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Bleomycin sulfate Property

Melting point:: 200-204°C (dec.)
storage temp.: 2-8°C
solubility: H₂O: 20 mg/mL
form: powder
color: white
Water Solubility: Soluble in water or DMSO
Merck: 14,1318
Stability:: Stable for 1 year from the date of purchase. Solutions in distilled water may be stored at -20°C for up to 3 months.
CAS DataBase Reference: 9041-93-4(CAS DataBase Reference)

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Safety

Hazard Codes: T,Xi
Risk Statements: 46-40-36/37/38-63
Safety Statements: 53-36/37-45-36-26
WGK Germany: 3
RTECS: EC5991990
F: 10
HS Code: 2941906000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H340May cause genetic defects

H351Suspected of causing cancer

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: B8416
Product name: Bleomycin sulfate from Streptomyces verticillus
Purity: 1.5-2.0?units/mg solid, BioReagent, suitable for cell culture
Packaging: 15units
Price: $1110
Updated: 2024/03/01

Sigma-Aldrich

Product number: B5507
Product name: Bleomycin sulfate from Streptomyces verticillus
Purity: crystalline, 1.5-2.0?U/mg
Packaging: 15units
Price: $888
Updated: 2024/03/01

Sigma-Aldrich

Product number: B2434
Product name: Bleomycin sulfate from Streptomyces verticillus
Purity: BioXtra, crystalline
Packaging: 20mg
Price: $1200
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1076308
Product name: Bleomycin sulfate
Packaging: 15mg
Price: $886
Updated: 2024/03/01

TCI Chemical

Product number: B3972
Product name: Bleomycin Sulfate (mixture)
Purity: >85.0%(HPLC)
Packaging: 10mg
Price: $193
Updated: 2024/03/01

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Bleomycin sulfate Chemical Properties,Usage,Production

Description

Bleomycin sulfate (9041-93-4) coordinates with metals producing reactive oxygen species which causes oxidative damage to DNA1?and RNA2. Induces double-strand DNA damage.3?Commonly used to induce lung fibrosis in animal disease models.4,5?Anticancer agent in clinical use.6

Chemical Properties

White Powder

Uses

A group of related glycopeptide antibiotics. Bleomycin A2 is the main component of the bleomycin employed clinically. Antineoplastic

Uses

Bleomycin is a complex of 11 glycopeptide antitumour antibiotics originally isolated from Streptomyces verticillus in 1972. The dominant components of the complex are bleomycin A2 and B2, which typically represent >90% of the total weight . Bleomycins have found clinical application in the treatment of a range of tumours. Bleomycins act by intercalation of DNA and RNA. In the presence of oxygen and metal ions, notably copper and iron, bleomycins form a pseudo-enzyme that induces DNA cleavage.

Uses

Bleomycin is a complex of 11 glycopeptide antitumor antibiotics originally isolated from Streptomyces verticillus in 1972. The dominant components of the complex are bleomycin A2 and B2, which typically represent >90% of the total weight. Bleomycins have found clinical application in the treatment of a range of tumors. Bleomycins act by intercalation of DNA and RNA. In the presence of oxygen and metal ions, notably copper and iron, bleomycins form a pseudo-enzyme that induces DNA cleavage.

Uses

Bleomycin sulfate binds to DNA, and can inhibit DNA synthesis and causes scission of DNA. Cleaves DNA, requires binding to oxygen and a metal ion, such as copper or iron. Able to cleave RNA, but at less and more selective degree. Also reported to induce and regulate apoptosis in a variety of cells, and inhibit tumor angiogenesis.

brand name

Blenoxane (Bristol-Myers Squibb).

General Description

Bleomycin occurs as a white powder and is available in 15-and 30-U vials for reconstitution in water. It may be givenintravenously, intramuscularly, or subcutaneously. It is used in the treatment of squamous cell carcinoma of the headneck, cervix, penis, and vulva. It is also used in Hodgkin’sand non-Hodgkin’s lymphoma as well as testicular carcinoma.Unlabeled uses include the treatment of mycosis fungoides,osteosarcoma, and AIDS-related Kaposi sarcoma.

Biochem/physiol Actions

Bleomycin sulfate binds to DNA, causes ssDNA scission at specific base sequences and inhibits DNA synthesis. This inhibitory action requires bleomycin to bind oxygen and a metal ion. It can also cleave RNA, to a lesser degree but more selectively. It acts as an inducer and regulator of apoptosis and inhibits tumor angiogenesis.

Clinical Use

Bleomycin is used IV in the palliative treatment of squamous cell head and neck cancers, testicular and other genital carcinomas, and Hodgkin's and non-Hodgkin's lymphoma.

Side effects

It is excreted via the kidneys, and serum concentrations of active drug are increased in patients with renal disease. The elimination half-life can rise from 2 to 4 hours to more than 20 hours in renal failure, resulting in significant toxicity, especially pulmonary toxicity.

Veterinary Drugs and Treatments

Bleomycin has occasionally been used as adjunctive treatment of lymphomas, squamous cell carcinomas, teratomas, and nonfunctional thyroid tumors in both dogs and cats. Recent work has demonstrated that bleomycin may be promising for intralesional treatment for a variety of localized tumors with or without concomitant electropermeabilization.

target

UT-SCC-129 cells

References

1) Petering?et al.?(1990),?The role of redox-active metals in the mechanism of action of bleomycin; Chem. Biol. Interact.,?73?133 2) Huttenhofer?et al. (1992),?Cleavage of tRNA by Fe(II)-bleomycin; J. Biol. Chem.,?267?24471 3) Lee?et al.?(2017)?ASF1a Promotes Non-homologous End Joining Repair by facilitating Phosphorylation of MDC1 by ATM at Double-Strand Breaks;?Mol. Cell?68?61 4)?Xie?et al.?(2016), Upregulation of RGS2: a new mechanism for pirfenidone amelioration of pulmonary fibrosis; Respir. Res.,?17?103 5) Inomata?et al. (2014) Pirfenidone inhibits fibrocyte accumulation in the lungs in bleomycin-induced murine pulmonary fibrosis; Respir. Res.,?15?16 6) Tanaka?et al. (2008)?Increased glutathione level is not involved in enhanced bleomycin sensitivity in cisplatin-resistant 2780CP cells; Anticancer Res.,?28?2663

Bleomycin sulfate Preparation Products And Raw materials

Raw materials

Methanol solution Zinc sulphate streptomyces avermifilis Dithizone Potassium Phosphate Monobasic Disodium edetate dihydrate Cation exchange resin,weak acidic acrylic acid corn syrup

Preparation Products

PEPLOMYCIN

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View Lastest Price from Bleomycin sulfate manufacturers

Ouhuang Engineering Materials (Hubei) Co., Ltd

Product: Bleomycin sulfate 9041-93-4
Price: US $15.00/kg
Min. Order: 1kg
Purity: 99.912%
Supply Ability: 10ton
Release date: 2024-04-25

Shaanxi Haibo Biotechnology Co., Ltd

Product: Bleomycin sulfate 9041-93-4
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000ton
Release date: 2023-09-07

Hebei Mojin Biotechnology Co., Ltd

Product: Bleomycin sulfate 9041-93-4
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-07-03

9041-93-4, Bleomycin sulfateRelated Search:

Magnesium sulfate heptahydrate Barium sulfate Potassium sulfate Ethyl acetate calcium sulfate Glycine Sodium thiosulfate pentahydrate Ethanol Neomycin sulfate Ferrous sulfate monohydrate Copper(II) sulfate Ethyl acrylate Aluminum sulfate Ammonium sulfate ALTRENOGEST Ethyl vanillin Sodium sulfate Ferrous sulfate heptahydrate

BLEOMYCIN SULFATE CELL CULTURE TESTED

BLEOMYCIN SULFATE, BPC

BLEOMYCIN SULFATE FROM STREPTOMYCES VERT ICILLUS, LYOPH.

BLEOMYCIN SULFATE FROM STREPTOMYCES VERTICILLUS 0 TO 5 °C

Blocamicina

BLEMOYCIN SULFATE

3-[[2-[2-[2-[2-[4-[2-[6-Amino-2-[1-(2-amino-2-carbamoyl-ethyl)amino-2-carbamoyl-ethyl]-5-methyl-pyrimidin-4-yl]carbonylamino-3-[3-[4-carbamoyloxy-3,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-3-(3H-imidazol-4-yl)propanoyl]amino-3-hydroxy-2-methyl-pentanoyl]amino-3-hydroxy-butanoyl]aminoethyl]-1,3-thiazol-4-yl]-1,3-thiazol-4-yl]carbonylamino]propyl-dimethyl-sulfonium hydrogen sulfate

Bleomycin Sulfate, Blenoxane

BleoMycin Sufate

(3-{[2-(2-{2-[(2S,3R)-2-[(2S,3S,4R)-4-[(2S,3R)-2-({6-aMino-2-[(1S)-1-{[(2S)-2-aMino-2-carbaMoylethyl]aMino}-2-carbaMoylethyl]-5-MethylpyriMidin-4-yl}forMaMido)-3-{[(2R,3S,4R,5R,6S)-3-{[(2S,3S,4R,5S,6S)-4-(carbaMoyloxy)-3,5-dihydroxy-6-(hydroxyMethyl)oxan-

BleoMycin sulfate API

Blenoxane, Bleo, Blexane

Bleomycin Sulfate (15 mg)

Bleomycin Sulfate (A mixture of bleomycin sulfate salts) >90%

Bleomycin Sulfate (A mixture of bleomycin sulfate salts)

Bleomycin sulfate - mixture of Bleomycin A2, B2, B4

Blenoxane, Bleo

Blenmycins

bleomycin,sulfate(salt)

NSC-125066

BLEOMYCIN SULFATE

BLEOMYCIN SULPHATE

BLEOMYCIN SULFATE, STREPTOMYCES VERTICILLUS

BLEXANE

BLEO

BLENOXANE

bleomycin sulfate from streptomyces verticillus

BleoMycin coMplex

BleoMycin-sulfate lyophil. pure

BleoMycin Blenoxane

Bleomycin sulfate, 1.5-2.0 units/mg

Bleomycin Sulfate (mixture)

Bleomycin Sulfate, Streptomyces verticillus - CAS 9041-93-4 - Calbiochem

Bleomycin sulfate - mixture of Bleomycin A2, B2

Bleomycin Sulfate (A mixture of bleomycin sulfate salts) &gt

Bleomycin sulfate CRS

Bleomycin Sulfate (mixture)&gt

Bleomycin sulphate, Comet assay grade

Bleomycin sulfate USP/EP/BP

Bleomycin Sulfate (Mixture of Bleomycin A2 & Bleomycin B2)Q: What is Bleomycin Sulfate (Mixture of Bleomycin A2 & Bleomycin B2) Q: What is the CAS Number of Bleomycin Sulfate (Mixture of Bleomycin A2 & Bleomycin B2) Q: What is the storage condition of Bleomycin Sulfate (Mixture of Bleomycin A2 & Bleomycin B2) Q: What are the applications of Bleomycin Sulfate (Mixture of Bleomycin A2 & Bleomycin B2)

Bleomycin Sulfate (BLM-S), 90%

Bleomycin Sulfate (1076308)

inhibit,Bleomycin Sulfate,DNA/RNA Synthesis,Antibiotic,Bleomycin,Inhibitor

Bleomycin sulfate（1:x）

Bleomycin Sulfate, USP

BLEO cell

BLEOcell

BLEO-cell

Bleolem

Bleomycin (NSC125066) sulfate

9041-93-4

C110H168N34O46S7

C55H84N17O21S3HSO4

C50H75N17O25S3

A2C55H84N17O21S3

2C55H84N17O21S3O4S

C55H85N17O25S4

C55H84O17N21S3