Growth hormone releasing peptide
- Product Name
- Growth hormone releasing peptide
- CAS No.
- 87616-84-0
- Chemical Name
- Growth hormone releasing peptide
- Synonyms
- GHRP-6;Growth;GHRP-6 ACETATE;gonadorel;sk&f110679;HWAWFK-NH2;GHRP-6220vial;GHRP-6 powder;GRHP-6 Acetate;[HIS1, LYS6]-GHRP
- CBNumber
- CB8421540
- Molecular Formula
- C46H56N12O6
- Formula Weight
- 873.01
- MOL File
- 87616-84-0.mol
Growth hormone releasing peptide Property
- Melting point:
- >160o C (Dec.)
- Boiling point:
- 1407.0±65.0 °C(Predicted)
- Density
- 1.333±0.06 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- Methanol (Slightly), Water (Slightly)
- form
- Solid
- pka
- 13.42±0.46(Predicted)
- color
- White to Off-White
- Sequence
- is-D-Trp-Ala-Trp-D-Phe-Lys-NH2|H-His-D-Trp-Ala-Trp-D-Phe-Lys-NH2
- InChI
- InChI=1S/C46H56N12O6/c1-27(54-44(62)39(20-29-23-51-35-15-7-5-13-32(29)35)57-43(61)34(48)22-31-25-50-26-53-31)42(60)56-40(21-30-24-52-36-16-8-6-14-33(30)36)46(64)58-38(19-28-11-3-2-4-12-28)45(63)55-37(41(49)59)17-9-10-18-47/h2-8,11-16,23-27,34,37-40,51-52H,9-10,17-22,47-48H2,1H3,(H2,49,59)(H,50,53)(H,54,62)(H,55,63)(H,56,60)(H,57,61)(H,58,64)/t27-,34-,37-,38+,39+,40-/m0/s1
- InChIKey
- WZHKXNSOCOQYQX-FUAFALNISA-N
- SMILES
- C(N)(=O)[C@H](CCCCN)NC(=O)[C@@H](CC1=CC=CC=C1)NC(=O)[C@H](CC1C2=C(C=CC=C2)NC=1)NC(=O)[C@H](C)NC(=O)[C@@H](CC1C2=C(C=CC=C2)NC=1)NC(=O)[C@H](CC1N=CNC=1)N
- CAS DataBase Reference
- 87616-84-0(CAS DataBase Reference)
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M2910
- Product name
- [D-Trp7, Ala8, D-Phe10]-α-Melanocyte Stimulating Hormone Amide Fragment 6-11
- Purity
- ≥97% (HPLC)
- Packaging
- 5mg
- Price
- $160.2
- Updated
- 2024/03/01
- Product number
- J66373
- Product name
- Growth Hormone Releasing Hexapeptide
- Packaging
- 25mg
- Price
- $289
- Updated
- 2023/06/20
- Product number
- J66373
- Product name
- Growth Hormone Releasing Hexapeptide
- Packaging
- 5mg
- Price
- $98.8
- Updated
- 2021/12/16
- Product number
- G9000-21V
- Product name
- Growth Hormone Releasing Peptide
- Packaging
- 1mg
- Price
- $531
- Updated
- 2021/12/16
- Product number
- 208931
- Product name
- Growth Hormone Releasing Peptide-6
- Packaging
- 5mg
- Price
- $418
- Updated
- 2021/12/16
Growth hormone releasing peptide Chemical Properties,Usage,Production
Description
Growth hormone-releasing peptides (GHRPs) are synthetic, non-natural peptides endowed with potent stimulatory effects on somatotrope secretion in animals and humans. They have no structural homology with GHRH and act via specific receptors present either at the pituitary or the hypothalamic level both in animals and in humans.
Uses
L-Histidyl-D-tryptophyl-L-alanyl-L-tryptophyl-D-phenylalanyl-L-lysinamide is a growth hormone releasing peptide.
Uses
Growth hormone releasing peptide-6 can promote the secretion of growth hormone, regulate food intake, increase weight, and promote animal growth.
benefits
When Growth hormone releasing peptide is administered, a selective pulse is sent to the brain that stimulates the hypothalamus and anterior pituitary to release growth hormones. Once this pulse is sent, the cells go directly to the muscle to support development while staying clear of any possible bone or cartilage growth. When the Peptide is injected it increases cell synthesis, elevates secretion levels of insulin from pancreatic tissue, and increases ghrelin in the stomach—which helps release GH and control hunger. All of these functions work to promote fat loss, shuttling of nutrients, and building clean muscle mass.
Biological Functions
Growth hormone releasing peptide (GHRH) is an endocrine hormone produced in the hypothalamus that acts on the receptors (GHRH-R) of the anterior pituitary gland to stimulate the release of growth hormone (GH). GHRH includes GHRH-2 and GHRH-6, which have slightly different functions. GHRH-2 is widely used to diagnose patients with growth hormone deficiency (GHD) and is believed to induce not only growth hormone (GH) release, but also adrenocorticotropic hormone (ACTH) release. GHRH-6 is part of a group of synthetic small peptides with potent growth hormone releasing activity, which has cellular and cardioprotective effects and can be used in heart disease treatment research.
Mechanism of action
Growth hormone releasing peptide is generally accepted that GHRPs stimulate the release of GH by acting at the level of the pituitary through a receptor different to that for the endogenous GH-releasing hormone (GHRH). In addition, it has been reported that there are specific binding sites for these peptides in the hypothalamus and that systemic administration of GHRPs increases the expression of the immediate early gene c-fos in a subpopulation of hypothalamic neurons.
Side effects
Carpal tunnel syndrome.Increased insulin resistance.
Type 2 diabetes.
Swelling in the arms and legs (edema)
Joint and muscle pain.
For men, enlargement of breast tissue (gynecomastia).
Increased risk of certain cancers.
Physiological effects
Growth hormone releasing peptide (GHRP) is a cyclase inhibitor that blocks the release of endogenous growth hormone.The peptide acts on both igf-i and somatotrophs, with receptor activity in the hypothalamus.GHRP can be used to increase body weight and control obesity.It has been shown to stimulate cell division and inhibit apoptosis in vitro.
Solubility in water
It is recommended to reconstitute the lyophilized growth hormone releasing peptide in sterile 18MΩ-cm H2O not less than 100 μg/ml, which can then be further diluted to other aqueous solutions.
storage
Lyophilized Growth hormone releasing peptide although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Growth hormone releasing peptide should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Growth hormone releasing peptide Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Growth hormone releasing peptide manufacturers
- Product
- GHRP-6 Acetate 87616-84-0
- Price
- US $0.00/G
- Min. Order
- 1G
- Purity
- 99%
- Supply Ability
- 20
- Release date
- 2024-10-17
- Product
- GHRP-6 Acetate/Hexapeptide-2/Growth hormone releasing peptide/ 87616-84-0
- Price
- US $0.00-0.00/box
- Min. Order
- 1box
- Purity
- 98
- Supply Ability
- 20000box
- Release date
- 2024-05-28
- Product
- GHRP-6 Acetate 87616-84-0
- Price
- US $30.00/box
- Min. Order
- 1box
- Purity
- 99%
- Supply Ability
- 1000box/month
- Release date
- 2024-11-14