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Growth hormone releasing peptide

Product Name
Growth hormone releasing peptide
CAS No.
87616-84-0
Chemical Name
Growth hormone releasing peptide
Synonyms
GHRP-6;Growth;GHRP-6 ACETATE;gonadorel;sk&f110679;HWAWFK-NH2;GHRP-6220vial;GHRP-6 powder;GRHP-6 Acetate;[HIS1, LYS6]-GHRP
CBNumber
CB8421540
Molecular Formula
C46H56N12O6
Formula Weight
873.01
MOL File
87616-84-0.mol
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Growth hormone releasing peptide Property

Melting point:
>160o C (Dec.)
Boiling point:
1407.0±65.0 °C(Predicted)
Density 
1.333±0.06 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
Methanol (Slightly), Water (Slightly)
form 
Solid
pka
13.42±0.46(Predicted)
color 
White to Off-White
Sequence
is-D-Trp-Ala-Trp-D-Phe-Lys-NH2|H-His-D-Trp-Ala-Trp-D-Phe-Lys-NH2
InChI
InChI=1S/C46H56N12O6/c1-27(54-44(62)39(20-29-23-51-35-15-7-5-13-32(29)35)57-43(61)34(48)22-31-25-50-26-53-31)42(60)56-40(21-30-24-52-36-16-8-6-14-33(30)36)46(64)58-38(19-28-11-3-2-4-12-28)45(63)55-37(41(49)59)17-9-10-18-47/h2-8,11-16,23-27,34,37-40,51-52H,9-10,17-22,47-48H2,1H3,(H2,49,59)(H,50,53)(H,54,62)(H,55,63)(H,56,60)(H,57,61)(H,58,64)/t27-,34-,37-,38+,39+,40-/m0/s1
InChIKey
WZHKXNSOCOQYQX-FUAFALNISA-N
SMILES
C(N)(=O)[C@H](CCCCN)NC(=O)[C@@H](CC1=CC=CC=C1)NC(=O)[C@H](CC1C2=C(C=CC=C2)NC=1)NC(=O)[C@H](C)NC(=O)[C@@H](CC1C2=C(C=CC=C2)NC=1)NC(=O)[C@H](CC1N=CNC=1)N
CAS DataBase Reference
87616-84-0(CAS DataBase Reference)
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
M2910
Product name
[D-Trp7, Ala8, D-Phe10]-α-Melanocyte Stimulating Hormone Amide Fragment 6-11
Purity
≥97% (HPLC)
Packaging
5mg
Price
$160.2
Updated
2024/03/01
Alfa Aesar
Product number
J66373
Product name
Growth Hormone Releasing Hexapeptide
Packaging
25mg
Price
$289
Updated
2023/06/20
Alfa Aesar
Product number
J66373
Product name
Growth Hormone Releasing Hexapeptide
Packaging
5mg
Price
$98.8
Updated
2021/12/16
Usbiological
Product number
G9000-21V
Product name
Growth Hormone Releasing Peptide
Packaging
1mg
Price
$531
Updated
2021/12/16
Usbiological
Product number
208931
Product name
Growth Hormone Releasing Peptide-6
Packaging
5mg
Price
$418
Updated
2021/12/16
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Growth hormone releasing peptide Chemical Properties,Usage,Production

Description

Growth hormone-releasing peptides (GHRPs) are synthetic, non-natural peptides endowed with potent stimulatory effects on somatotrope secretion in animals and humans. They have no structural homology with GHRH and act via specific receptors present either at the pituitary or the hypothalamic level both in animals and in humans.

Uses

L-Histidyl-D-tryptophyl-L-alanyl-L-tryptophyl-D-phenylalanyl-L-lysinamide is a growth hormone releasing peptide.

Uses

Growth hormone releasing peptide-6 can promote the secretion of growth hormone, regulate food intake, increase weight, and promote animal growth.

benefits

When Growth hormone releasing peptide is administered, a selective pulse is sent to the brain that stimulates the hypothalamus and anterior pituitary to release growth hormones. Once this pulse is sent, the cells go directly to the muscle to support development while staying clear of any possible bone or cartilage growth. When the Peptide is injected it increases cell synthesis, elevates secretion levels of insulin from pancreatic tissue, and increases ghrelin in the stomach—which helps release GH and control hunger. All of these functions work to promote fat loss, shuttling of nutrients, and building clean muscle mass.

Biological Functions

Growth hormone releasing peptide (GHRH) is an endocrine hormone produced in the hypothalamus that acts on the receptors (GHRH-R) of the anterior pituitary gland to stimulate the release of growth hormone (GH).  GHRH includes GHRH-2 and GHRH-6, which have slightly different functions.  GHRH-2 is widely used to diagnose patients with growth hormone deficiency (GHD) and is believed to induce not only growth hormone (GH) release, but also adrenocorticotropic hormone (ACTH) release. GHRH-6 is part of a group of synthetic small peptides with potent growth hormone releasing activity, which has cellular and cardioprotective effects and can be used in heart disease treatment research.

Mechanism of action

Growth hormone releasing peptide is generally accepted that GHRPs stimulate the release of GH by acting at the level of the pituitary through a receptor different to that for the endogenous GH-releasing hormone (GHRH). In addition, it has been reported that there are specific binding sites for these peptides in the hypothalamus and that systemic administration of GHRPs increases the expression of the immediate early gene c-fos in a subpopulation of hypothalamic neurons.

Side effects

Carpal tunnel syndrome.Increased insulin resistance.
Type 2 diabetes.
Swelling in the arms and legs (edema)
Joint and muscle pain.
For men, enlargement of breast tissue (gynecomastia).
Increased risk of certain cancers.

Physiological effects

Growth hormone releasing peptide (GHRP) is a cyclase inhibitor that blocks the release of endogenous growth hormone.The peptide acts on both igf-i and somatotrophs, with receptor activity in the hypothalamus.GHRP can be used to increase body weight and control obesity.It has been shown to stimulate cell division and inhibit apoptosis in vitro.

Solubility in water

It is recommended to reconstitute the lyophilized growth hormone releasing peptide in sterile 18MΩ-cm H2O not less than 100 μg/ml, which can then be further diluted to other aqueous solutions.

storage

Lyophilized Growth hormone releasing peptide although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Growth hormone releasing peptide should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Growth hormone releasing peptide Preparation Products And Raw materials

Raw materials

Preparation Products

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Growth hormone releasing peptide Suppliers

China 238 France 1 Germany 3 India 8 South Korea 1 Switzerland 1 The Netherlands 1 United States 20 Global 273
LGM Pharma
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View Lastest Price from Growth hormone releasing peptide manufacturers

CONTIDE BIOTECH CO.,LTD
Product
GHRP-6 Acetate 87616-84-0
Price
US $0.00/G
Min. Order
1G
Purity
99%
Supply Ability
20
Release date
2024-10-17
Shanghai Affida new material science and technology center
Product
GHRP-6 Acetate/Hexapeptide-2/Growth hormone releasing peptide/ 87616-84-0
Price
US $0.00-0.00/box
Min. Order
1box
Purity
98
Supply Ability
20000box
Release date
2024-05-28
Huaian Banting Trading Co., Ltd.
Product
GHRP-6 Acetate 87616-84-0
Price
US $30.00/box
Min. Order
1box
Purity
99%
Supply Ability
1000box/month
Release date
2024-11-14

87616-84-0, Growth hormone releasing peptideRelated Search:

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